Article

Environmental and developmental origins of ovarian reserve

Academic Unit of Human Development and Health, University of Southampton, Southampton SO16 5YA UK.
Human Reproduction Update (Impact Factor: 10.17). 11/2013; 20(3). DOI: 10.1093/humupd/dmt057
Source: PubMed

ABSTRACT

BACKGROUND Oocyte number is established early in life before a gradual loss of this ovarian reserve during reproductive life until oocyte
availability becomes limiting at the menopause. Although there is a large genetic component to the ovarian reserve achieved
before birth, other influences including the maternal endocrine and nutritional milieu, and environmental factors may represent
important developmental determinants. Environmental and nutritional factors may also modify the downward trajectory of ovarian
reserve in adult life. The combination of these early and later life influences has the potential to lead to diminished ovarian
reserve, compromising fertility in later reproductive years and altering age at natural menopause.

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Available from: Nick Macklon, Nov 13, 2014
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