Custom Cerium Oxide Nanoparticles Protect Against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain.

ACS Nano (Impact Factor: 12.88). 11/2013; 7(12). DOI: 10.1021/nn403743b
Source: PubMed


Cerium oxide nanoparticles are potent antioxidants, based on their ability to either donate or receive electrons as they alternate between the +3 and +4 valence states. The dual oxidation state of ceria has made it an ideal catalyst in industrial applications, and more recently, nanoceria's efficacy in neutralizing biologically generated free radicals has been explored in biological applications. Here we report the in vivo characteristics of custom-synthesized cerium oxide nanoparticles (CeNPs) in an animal model of immunological and free-radical mediated oxidative injury leading to neurodegenerative disease. The CeNPs are 2.9 nm in diameter, monodispersed and have a -23.5 mV zeta potential when stabilized with citrate/EDTA. This stabilizer coating resists being 'washed' off in physiological salt solutions, and the CeNPs remain monodispersed for long durations in high ionic strength saline. The plasma half-life of the CeNPs is ~4.0 hours, far longer than previously described, stabilized ceria nanoparticles. When administered intravenously to mice, the CeNPs were well tolerated and taken up by the liver and spleen much less than previous nanoceria formulations. The CeNPs were also able to penetrate the brain, reduce reactive oxygen species levels and alleviate clinical symptoms and motor deficits in mice with a murine model of multiple sclerosis. Thus, CeNPs may be useful in mitigating tissue damage arising from free radical accumulation in biological systems.

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Available from: Joseph S Erlichman, May 20, 2014
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    • "Reduce reactive oxygen species levels in the brain cells and prevent degenerative diseases Heckman et al., 2013 Reduced Retinal damage 20μl of 1mM in saline Decrease ROS regulate the expression of neuroprotection genes apoptosis Kong et al., 2011 Reduced Ischemia 3nm PEGylated Scavenging ROS reducing apoptosis in cerebral artery Kim et al., 2012 Cardiomyopathy CeO-NPs Inhibited progressive left ventricular dysfunction and dilatation caused a significant decrease in serum levels Niu et al., 2007 Cerebellum treatment 15 nm CeO2 Mimetic the SOD activity. Ganesana et al., 2012 Tumor cells reduction 15-20nm/ CeTiO2 Sensitive the tumor cells to radiotherapy. "
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