Neurologic Complications of Metronidazole

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Impact Factor: 1.53). 11/2013; 40(6):768-776. DOI: 10.1017/S0317167100015870
Source: PubMed


Metronidazole (Flagyl®) is an antimicrobial agent commonly used in clinical practice. Although it is generally well tolerated with minimal side effects, there are a host of still under-recognized neurologic complications of metronidazole treatment. The following review is aimed at summarizing current literature pertaining to metronidazole-induced neurotoxicity including clinical syndromes, neuroradiological findings, prognosis and proposed pathophysiology. Recognition of the neurotoxic effects of metronidazole is critical as prompt discontinuation is generally associated with full clinical recovery and radiological resolution.

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    • "There are several reports describing cases with cerebellar ataxia in association with the use of antimicrobials [253– 275]. Ataxia caused by metronidazole was often related to high cumulative doses [276]. Patients presented with dysarthria and ataxia, and hyperintensities in the cerebellar nuclei and cerebellar white matter have been described on MRI T2. "
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