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Study on Hypolipidemic Activities of Safflower Seed Oil

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Applied Mechanics and Materials
Authors:
Jian Xia Guo
Jian Xia Guo
Changlu Wang at Tianjin University of Science and Technology (TUST)
Changlu Wang
  • Tianjin University of Science and Technology (TUST)
Zhi Jian Wu
Zhi Jian Wu
Zhi Jian Wu
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Abstract

Safflower seed oil is known to be one of the richest natural sources of linoleic acid (LA), with values of up to 69.5% of the total fatty acids. Linoleic acid is known to has important biological activity and its absence in a normal diet has been described as responsible for the development of a wide variety of diseases. This work reported purified LA from safflower seed oil could lower blood liquids level of rats with hyperlipidemia. It showed that purified LA from safflower seed oil could decrease the serum total cholesterol and triglyceride concentration significantly, as well as increase the serum high density lipoprotein cholesterol. The serum atherosclerosis index (AI) was decreased remarkably. It demonstrated purified LA from safflower seed oil could improve metabolism of serum lipids and it could play active role of preventing atherosclerosis.
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Study on Hypolipidemic Activities of Safflower Seed Oil
Jianxia Guo
1, a
, Changlu Wang
*2, b
and Zhijian Wu
3, c
1Department of Bioengineering, Tianjin Tianshi College, Tianjin 301700, P. R. China
2Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology),
Ministry of Education, Tianjin 300457, P. R. China
3Affiliated Hospital of Hebei Union University, Tangshan 063000, P. R. China
aguojianxia0001@yahoo.com.cn, b*Corresponding author: changluwang@yahoo.com.cn
cwuzhijian100@gmail.com
Keywords: Safflower, Seed oil, Linoleic acid, Hypolipidemic activities.
Abstract. Safflower seed oil is known to be one of the richest natural sources of linoleic acid (LA),
with values of up to 69.5% of the total fatty acids. Linoleic acid is known to has important biological
activity and its absence in a normal diet has been described as responsible for the development of a
wide variety of diseases. This work reported purified LA from safflower seed oil could lower blood
liquids level of rats with hyperlipidemia. It showed that purified LA from safflower seed oil could
decrease the serum total cholesterol and triglyceride concentration significantly, as well as increase
the serum high density lipoprotein cholesterol. The serum atherosclerosis index (AI) was decreased
remarkably. It demonstrated purified LA from safflower seed oil could improve metabolism of serum
lipids and it could play active role of preventing atherosclerosis.
Introduction
The polyunsaturated fatty acid linoleic acid (LA) has received increasing attention over the last years
due to its significance to human health. LA was shown to have several beneficial effects such as
preventing coronary heart diseases. Safflower is an important oilseed crop worldwide, yielding
approximately 45%–50% oil. Safflower seed oil is a kind of high quality edible plant oil. It is an
excellent source of the essential fatty acids LA required by the human body. LA is a (n-6) fatty acids
and it is one of an essential unsaturated fatty acids [1, 2]. Current research directions in nutrition
indicate that the (n-6) fatty acids are receiving increasing attention as essential components of the
human diet. Over the past 20–30 years, intake of n-6 fatty acids has increased because of extensive use
of vegetable oils in our diets. The fatty acid constituent of our diet plays a key role in health and
disease prevention. Studies have manifested that diet and dietary lipids have an considerable role to
play in the prevention of risk of cardiovascular diseases [3, 4].
In recent years there has been an increased interest among consumers in the nutritional
composition of food. Consumers are becoming more conscious of the link between diet and disease
and that compositions of food can have a positive or negative affection on their health. The research of
WHO indicated that people taking safflower seed oil as edible oil got disease of cardiovascular system
in a very low rate. Safflower seed oil is a widely consumed product with high nutritional value and
significant health benefits. It is known for its superior sense organ characteristics (taste) and
prominent antioxidant properties. The incidence of cardiovascular disease (CVD) is closely related to
diet, mainly to fat composition. The replacement of dietary saturated fat by polyunsaturated fats
observably lowers the plasma-cholesterol and the LDL-cholesterol (LDL-C) levels [5-8]. The amount
of essential fatty acids in the diet affected the mitochondrial composition and function. By decreasing
hypertriglyceridemia, blood platelet aggregation and lowering blood cholesterol, thus reducing the
risk of arteriosclerosis.
Dietary edible oils containing (n-6) fatty acids are increasingly being recommended for their
hypolipidemic (lowering blood lipids) effects for persons consuming typical western diets. In addition
to the underlying beneficial effects of (n-6) polyunsaturated fatty acids (PUFA) on circulating lipids,
these fatty acids have beneficial homeostatic effects that may be conducive to reducing the risk of
Applied Mechanics and Materials Online: 2013-01-11
ISSN: 1662-7482, Vols. 275-277, pp 1640-1645
doi:10.4028/www.scientific.net/AMM.275-277.1640
© 2013 Trans Tech Publications Ltd, All Rights Reserved
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