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Lipid lowering activity of fruits of Carum carvi Lin in cholesterol and triton fed hyperlipidemic rats
Abstract and Figures
Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-associated conditions such as coronary heart disease (CHD), ischemic cerebrovascular disease and peripheral vascular diseases. Moreover, current predictions estimate that by the year 2020 cardiovascular diseases, notably atherosclerosis will become the leading global cause of total disease burden. In the present paper, lipid lowering activity of methanolic extract of fruits of Carum carvi has been studied in cholesterol and triton fed hyperlipidemic rats. Co-administration of the methanolic extract (100 mg/kg and 50 mg/kg) to different groups showed inhibition in the rise of Total Cholesterol significantly when compared to cholesterol fed group (p<0.05) and was statistically non significant to vehicle group. Test drug at both the doses decreases significantly (p<0.01) the rise of TGL and VLDL when compared with group II. Similarly, test drug (100 mg/kg) increases significantly (p<0.01) HDL when compared with group I and II. Test drug has significantly lowered the TC/HDL ratio and AI in the hyperlipidemic rats. Test drug possess more lipid lowering effect on higher dose and hence have dose dependent effect.
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