What evidence to support antiviral treatment in children with chronic hepatitis B?

Department of Translational Medical Sciences, University Federico II, Naples, Italy.
Antiviral therapy (Impact Factor: 3.02). 11/2013; 19(3). DOI: 10.3851/IMP2704
Source: PubMed


Many questions are unanswered on the optimal management of chronically HBV-infected children. Chronic hepatitis B is generally a mild disease in children; response to therapy is partial and limited to specific subgroups; available drugs have no proven advantage on long-term course versus no treatment, and are hampered by numerous limits. Studies on natural history of chronic hepatitis B and the long-term results of the therapeutic schedules adopted so far should be critically appraised. A balance between the potential benefits of the treatment and its side effects, and the spontaneous course of the disease left untreated should be made.

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Available from: Maria Immacolata Spagnuolo, Apr 13, 2015