Incidence and Risk Factors for Incident Hepatitis C Infection Among Men Who Have Sex With Men With HIV-1 Infection in a Large Urban HIV Clinic in Tokyo

1AIDS Clinical Center 2Department of Clinical Study and Informatics, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan 3Center for AIDS Research, Kumamoto University, Kumamoto, Japan 4Department of Community Care, Saku Central Hospital.
JAIDS Journal of Acquired Immune Deficiency Syndromes (Impact Factor: 4.56). 10/2013; 65(2). DOI: 10.1097/QAI.0000000000000044
Source: PubMed


The epidemiology of hepatitis C virus (HCV) infection among HIV-infected men who have sex with men (MSM) who do not inject drugs in Asia remains unknown.
The incidence and risk factors for incident HCV infection among HIV-infected MSM at a large HIV clinic in Tokyo were elucidated. Poisson regression compared the incidence of HCV seroconversion at different observation periods.
Of 753 HIV-1 infected MSM patients negative for HCV antibody (HCVAb) at baseline and available follow-up HCVAb test, 21 patients (2.8%) seroconverted to HCVAb-positive over 2,246 person-years (PY), for an incidence of 9.35/1,000 PY. The incidence increased over time from 0/1,000 PY in 2005 to 2006, 3.0/1,000 PY in 2007 to 2008, 7.7/1,000 PY in 2009 to 2010, and 24.9/1,000 PY in 2011 to 2012 (p=0.012). Of 21 incident cases, only 4 (21%) were injection drug users, and sensitivity analysis that excluded injection drug users yielded similar findings. Multivariate analysis identified illicit drug use to be an independent risk for HCV infection (HR=3.006; 95%CI, 1.092-8.275; p=0.033).
Incident HCV infection is increasing among HIV-1-infected MSM non-injection drug users at resource-rich setting in Asia. Illicit drug use is an independent risk factor for incident HCV infection in this population.

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