Levels of physical inactivity are high around the globe and have remained stable over the last decade. Additionally, important social disparities in physical activity behaviors challenge the field of physical activity promotion (Guthold et al., 2018, 2020). Physical activity is a complex health behavior that is influenced by behavioral factors at the individual level (so-called downstream factors) as well as by factors from the social environment (so-called upstream factors) (Ball et al., 2015; Lorenc et al., 2013). However, not only in research but also in policy there currently is a focus on downstream factors (Bauman et al., 2012; Rutter et al., 2017). From a research perspective, this implies limited evidence on upstream factors applied to the context of physical activity (Alcántara et al., 2020; Jaeschke et al., 2017; O'Donoghue et al., 2018). From a policy perspective, this implies that governments tend to hold individuals responsible for their health behavior and thereby evade their responsibilities for creating physical-activity-enhancing conditions for all people (VicHealth, 2015). In light of these challenges, this doctoral thesis aims at contributing a new perspective to research in physical activity promotion. It adopts a human-rights-based approach and outlines how a potential human right to physical activity enhances accountability for physical activity at the state level. Moreover, this work examines the implications that the human-rights-based approach has on opportunities for physical activity, with a special interest in the promotion of equity in these opportunities. To achieve this goal, the principles of proportionate universalism (Marmot et al., 2010) and empowerment (Rappaport, 1987; WHO, 2018), as well as Sen’s capability approach (Sen, 2009), will guide this work. Manuscript A shows that a human right to physical activity can be deduced from the established human rights to health, education, and rest and leisure. It characterizes this human right by defining its attributes of availability, accessibility, acceptability, and quality in the context of physical activity. The principle of non-discrimination creates a focus on vulnerable and marginalized groups and strives for equity. Finally, the manuscript also describes concrete obligations, which can be deduced from this right at the state level, including a state’s obligation to respect, protect, and fulfill the right to physical activity for all people. From a perspective of physical activity promotion based on the principle of proportionate universalism (Marmot et al., 2010), a human-rights-based approach presents shortcomings with regard to achieving equity in opportunities for physical activity. One reason lies in the narrow focus on equality in dignity, legal standing and legal status and not on equality of social or economic position (Chapman, 2010). Moreover, the approach is deemed unsuitable to address relative inequalities (Chapman, 2010). This is of concern since knowledge of and action upon relative inequalities play an essential role in physical activity promotion to develop suitable interventions and programs (Howden-Chapman, 2010). To overcome these challenges, this work complements the human-rights-based perspective to physical activity with Sen’s capability approach (Sen, 2009). Considering the assessment of both capabilities and functionings as relevant to assess physical activity comprehensively, Manuscript B seeks to contribute evidence to a general understanding of the empirical nature of capabilities and functionings. Spanning a multidimensional evaluative space based on Anand and van Hees’s (2006) assessment tool for well-being, the results demonstrate that capabilities and functionings are similar but different concepts that can be empirically appraised as such by a representative sample of N= 58,615 young Swiss men. Moreover, capabilities and functionings are shown to be associated with each other and with economic, social, and cultural factors in the study population. In sum, this work concludes that the capability approach offers important benefits to address upstream factors (such as the social determinants of health) and relative inequalities, but challenges with regard to established power structures remain on the way to achieving equity. Therefore, Manuscript C acts upon the principle of empowerment (Rappaport, 1987; WHO, 2018) and assesses to what extent scientists of a transdisciplinary research consortium succeed in co-producing new knowledge for the enhancement of opportunities for physical activity. The co-production of knowledge is informed by the bottom-up participation of target groups in different settings over a project period of five years. Based on Hall et al.’s (2008) conceptual model for evaluation of collaborative initiatives, the project life is separated into the phases of collaborative readiness, collaborative capacity, and collaborative products to assess collaboration processes and outcomes within the consortium. It is assumed that the transdisciplinarily co-created knowledge might potentially enrich current research on physical activity through the provision of new insights into upstream factors relevant for enhancing equity in the opportunities to be active. The results of the manuscript underscore the time- and resource-consuming nature of transdisciplinary projects, as well as the need for adequate financial and long-term funding, for adequate personal resources, and for a central coordinating organ. Although issues of established power relations are not explicitly addressed in the study, the interpretation of results reveals structural barriers in the form of legislation hampering opportunities for knowledge co-creation in an academic setting. In conclusion, a human-rights-based approach to physical activity complemented by bottom-up strategies to enable participation and empowerment of target groups seems to be a promising strategy to address physical inactivity and related social disparities at the population level. The process of empowering target groups to take control over their physical activity behavior requires that individuals value the goal of being physically active and that they are involved in the process of bringing about this goal (López Barreda et al., 2019). Despite the scarce knowledge on determinants of physical activity, future research should focus on aligning the application of both physical-activity-related upstream and downstream factors to requirements for action in real-world settings. Transdisciplinary research might be a promising step towards achieving this goal. However, the co-creation of new knowledge to enhance people’s opportunities for physical activity in an effective way requires exploring suitable strategies to counterbalance established power structures operating in academic and transdisciplinary settings.