TREM2 and Neurodegenerative Disease

New England Journal of Medicine (Impact Factor: 55.87). 10/2013; 369(16):1564-70. DOI: 10.1056/NEJMc1306509#SA4
Source: PubMed


To the Editor: Guerreiro et al.(1) and Jonsson et al.(2) (Jan. 10 issue) report an association between the single-nucleotide polymorphism (SNP) rs75932628 in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) (predicting an R47H substitution) and Alzheimer's disease in persons of European ancestry. We and other members of the Alzheimer's Disease Genetics Consortium assembled multiple data sets from a total of 5896 black patients (1968 cases and 3928 controls). First, the association of Alzheimer's disease with genotyped and imputed SNPs was individually assessed in each data set with the use of logistic regression for . . .

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Available from: Bruno A. Benitez, Mar 27, 2014
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