This literature synthesis explores the topic of addressing sexual problems among women aged 20-39 years in rural primary health care centers in Karachi, Sindh, Pakistan, using the PLISSIT model. The study aims to provide an overview of relevant literature and highlight the importance of implementing the PLISSIT model in addressing sexual health issues in this specific population. The literature review was conducted through comprehensive searches using databases such as Google Scholar, PubMed, CINAHAL, and ScienceDirect. A total of 45 articles were selected for review, with a focus on research articles, review articles, reports, and books published within the past five years. The search strategy also included accessing relevant publications through the Aga Khan University library, resulting in the inclusion of 31 references for paraphrasing and inclusion in the study. The background section emphasizes the significance of reproductive health and sexual health as essential components of overall well-being. Sexual health is often considered a sensitive and taboo topic in rural communities, making it challenging to openly discuss sexual health issues. The literature review reveals those developing countries, including Pakistan, face challenges in addressing sexual health effectively. Limited awareness and information contribute to the prevalence of sexual problems and concerns among women. Specific educational programs, seminars, and workshops targeting rural communities are necessary to raise awareness and provide information about sexual behaviors and practices. The literature synthesis concludes by emphasizing the need for governments, policymakers, and public health authorities to prioritize sexual health as an integral component of overall health and well-being. The prevalence of female sexual dysfunction is found to be high in both developed and developing countries, including Iran. The review also highlights the marginalization and neglect of sexual health issues faced by women with disabilities. In conclusion, this literature synthesis provides a comprehensive overview of relevant literature related to sexual health issues among women aged 20-39 years in rural primary health care centers in Karachi, Sindh, Pakistan. This includes literature relevant to the study objectives. This synthesis starts with a drawing of the method of searching strategy to obtain data significant to the study topic. Google Scholar, PubMed, CINAHAL, and science direct were used as search databases. This whole chapter consists of six parts in which the first part is about sexual health and their perception globally, and the second part is about the prevalence of sexual problems among women globally, in Asia, and in Pakistan. Moreover, the third part is about sexual education, a counseling program for tackling sexual problems, while the fourth part is about the implementation of the PLISSIT model in primary health care centers, t h e fifth part is about a brief summary of the literature and the last part is about why my study is important and how it will contribute to the literature. SEARCH STRATEGY library. The searched literature filtered, recent publications about the past 5 years mostly selected reviews. About 45 articles were selected for the literature review and about 31 were referenced for paraphrase. Then finally the main body is paraphrased from the literature in a systematic way with resonating own ideas. BACKGROUND