ArticlePDF Available

Abstract

Ginseng is one of the most popular herbal sup-plements in the world. It is a plant widely used in folk and traditional medicines for cardiovascular, immune, nervous and endocrine systems, and according to the researchers, it has the ability to increase the non-specific resistance state, which characterizes it as an adaptogenic substance. There are different species of ginseng, such as the American, Chinese, Korean and Japanese ginseng; the Korean species (Panax ginseng) is being used for thousands of years as a tonic, prophylactic and "restorative" agent, with power-ful antioxidant properties. For a long time, its use was empirical, because people used to beli-eve that it was a panacea that promoted longe-vity, with beneficial effects for the treatment of physical fatigues. Nowadays, the active compo-nents of Eleutherococcus senticosus are well described, however, there are no data on the quantity of a certain class of these secondary compounds produced in each species. Although the Eleutherococcus senticosus extract may con-tain several substances, including vitamins, mi-nerals, cellulose, and ethanol, the substances responsible for inducing various physiological responses are the eleutherosides (in the root) and ciwujianosides (in the leaf). As Eleutheroco-ccus senticosus receives great attention by show-ing that its active components can provide protec-tion against oxidative stress, among other bene-fits, contributing to health and the prevention and treatment of diseases, such as diabetes, can-cer, cardiovascular disease and inflammation. The purpose of this article is to describe the main, adverse and toxicological effects of Eleuthero-coccus senticosus recently related in the litera-ture.
Vol.5, No.9, 1509-1515 (2013) Health
http://dx.doi.org/10.4236/health.2013.59205
Eleutherococcus senticosus: Studies and effects*
Aline Arouca, Dora Maria Grassi-Kassisse#
Department of Structural and Functional Biology, Laboratory of Stress Study, Institute of Biology, University of Campinas,
Campinas, Brazil; #Corresponding Author: doramgk@unicamp.br, alineb.arouca@gmail.com
Received 13 June 2013; revised 14 July 2013; accepted 19 August 2013
Copyright © 2013 Aline Arouca, Dora Maria Grassi-Kassisse. This is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
ABSTRACT
Ginseng is one of the most popular herbal sup-
plements in the world. It is a plant widely used in
folk and traditional medicines for cardiovascular,
immune, nervous and endocrine systems, and
according to the researchers, it has the ability to
increase the non-specific resistance state, which
characterizes it as an adaptogenic substance.
There are different species of ginseng, such as
the American, Chinese, Korean and Japanese
ginseng; the Korean species (Panax ginseng) is
being used for thousands of years as a tonic,
prophylactic and “restorative” agent, with power-
ful antioxidant properties. For a long time, its
use was empirical, because people used to beli-
eve that it was a panacea that promoted longe-
vity, with beneficial effects for the treatment of
physical fatigues. Nowadays, the active compo-
nents of Eleutherococcus senticosus are well
described, however, there are no data on the
quantity of a certain class of these secondary
compounds produced in each species. Although
the Eleutherococcus senticosus extract may con-
tain several substances, including vitamins, mi-
nerals, cellulose, and ethanol, the substances
responsible for inducing various physiological
responses are the eleutherosides (in the root)
and ciwujianosides (in the leaf). As Eleutheroco-
ccus senticosus receives great attention by show-
ing that its active components can provide protec-
tion against oxidative stress, among other bene-
fits, contributing to health and the prevention
and treatment of diseases, such as diabetes, can-
cer, cardiovascular disease and inflammation.
The purpose of this article is to describe the main,
adverse and toxicological effects of Eleuthero-
coccus senticosus recently related in the litera-
ture.
Keywords: Eleutherococcus senticosus; Ginseng;
Eleutherosides; Ciwujianosides
1. INTRODUCTION
Eleutherococcus senticosus, world widely known as
Acanthopanax senticosus (Rupr. et Maxim), belongs to
the Araliaceae plant family, as well as other types of gin-
seng (Latin name), a generic term given to all species of
Panax [1]. It is also known as Siberian or Russian ginseng,
ciwujia, eleuthero, eleuthero ginseng, touch-me-not and
devil’s shrub [2,3].
Ginseng is one of the most popular herbal supplements
in the world [2]. It is a widely used plant in folk and tra-
ditional medicines for the cardiovascular, immune, ner-
vous, and endocrine systems, and according to the resear-
chers Brekhman & Dardymov (1969) [4], it has the ability
to increase the non-specific resistance state, which charac-
terizes it as an adaptogenic substance.
There are other species of ginseng, such as the Ame-
rican, Chinese, Korean and Japanese ginseng [5]; the Ko-
rean species (Panax ginseng) is being used for thousands
of years as a tonic, prophylactic and “restorative” agent
(3), with powerful antioxidant properties [6]. For a long
time, its use was empirical, because people used to believe
it was a panacea that promoted longevity, with beneficial
effects for the treatment of physical fatigue [7].
The use of Panax as a source of raw materials for phar-
maceuticals was very expensive for many years [2,5].
Therefore, a group of Russian researchers looked for al-
ternatives, and after the discovery, many years later, at the
end of 1950, Eleutherococcus senticosus (ES) was recog-
nized as a new medicinal plant [2,3]. Despite having been
described only in 1950, Eleutherococcus senticosus is a
plant used by the Chinese for over 2000 years. Some re-
ports describe its use as a medicinal remedy for the treat-
ment of infections, resistance to fatigue and for immuno-
logical improvement [8].
*This study was supported by CAPES.
Copyright © 2013 SciRes. OPEN ACCESS
A. Arouca, D. M. Grassi-Kassisse / Health 5 (2013) 1509-1515
1510
In 1982, Baranov [9] concluded that the chronic admi-
nistration of Eleutherococcus senticosus was more advan-
tageous when compared to Panax, because it does not
cause arousal in patients. It has a more intense protective
effect on the immune system; in addition, it does not lead
to the development of a similar stress syndrome. The
seasonality influences the effects of these two types of
ginseng, but there is not much variation in Eleutheroco-
ccus senticosus (ES) [3].
ES was recently included in the European Pharmaco-
poeia as a medicine derived from plants and it is, therefore,
suitable for use in traditional herbal medicines and asso-
ciations [10].
The 1994 DSHEA (Dietary Supplement Health and
Education Act) regulation allows a direct commercializa-
tion of ES as a supplement for consumption in the United
States without the regulation of the FDA (Food and Drug
Administration) [11].
2. ACTIVE COMPONENTS OF
ELEUTHEROCOCCUS SENTICOSUS
The active components of Eleutherococcus senticosus,
the eleutherosides, were initially coded from A to F [12],
and years later, Hikino et al. (1986) [13] studied seven
eleutherosides coded as A, B, C, D, E, F and G, and
through acid hydrolysis of these components, obtained the
formation of glycosides, such as rhamnose, arabinose, xy-
lose, mannose, galactose and glucose.
Based on several studies by Wagner et al. (1994) [14],
the ES components were rated as phenylpropanes, com-
pounds, lignans, coumarins, polysaccharides and other
compounds, such as oleanolic acid, aromatic oils and
sugar [8]. In an attempt to bring order to these chemicals
compounds, ES was divided into two classes: 1. Triterpe-
noid saponins, which are glycosides of oleanolic acid (re-
ferred to as eleutherosides I, K, L and M), and 2. Phenyl-
propane derivatives (eleutherosides B, B1, D and E), which
are mostly glycosylated [15].
The ES root extract is standardized in 0.6% to 0.8% of
eleutherosides, depending on the extraction method of so-
lids [16,17].
Unfortunately, there are no data on the quantity of a
certain class of these secondary compounds produced in
each species. These compounds include, but are not limit-
ed to, phenylpropanoids (siringina, caffeic acid, sinapyl
alcohol, and coniferyl aldehyde), lignans (sesamin, syrin-
garesinol and its glycoside), saponins (daucosterol, β-sito-
sterol, and hederasaponine-B), coumarins (isofraxidine and
its glycoside) and vitamins (vitamin E and beta-carotene)
[15].
Eleutherococcus not only synthesizes lignans, but also
siringina, syringaresinol and sesamin; it produces and ac-
cumulates precursors of lignans, such as hydroxycinna-
mic caffeic acid and other intermediate compounds, as co-
niferaldehyde. These precursors have shown a significant
antioxidant activity [15].
Although the Eleutherococcus senticosus extract may
contain several substances, including vitamins, minerals,
cellulose and ethanol [14], the substances responsible for
inducing various physiological responses are the eleuthe-
rosides (in the root) and ciwujianosides (in the leaf) [1].
3. MAIN EFFECTS OF
ELEUTHEROCOCCUS SENTICOSUS
Eleutherococcus senticosus, as well as Panax ginseng,
seems to have a stimulating effect on the metabolism of
substrates, as it significantly alters the mobilization and
utilization of carbohydrates and fatty acids. Since the
metabolism of substrates is essential, different types of
ginseng can have ergogenic effect [5]. Table 1 shows se-
veral studies performed in humans, using a supplemen-
tation made from ES, among other types of ginseng. Ac-
cording to the studies, we may observe that the acute
supplementation has no effect on physical performance,
whereas chronic supplementation can provide significant
changes in various biochemical parameters.
Some studies, using the supplementation of Eleuthero-
coccus senticosus, report an improvement in heart rate
recovery after physical exercise, improvement of the lac-
tate removal ability, greater ability to obtain energy from
aerobic metabolism (by increasing the oxygen consump-
tion and utilization of fatty acids as a source of energy)
and, therefore, an improvement of the performance [3,8,
18-20]. These authors believe that these improvements
are due to the action of eleutherosides, responsible for in-
ducing various physiological responses, which are pre-
sent in the root of Eleutherococcus senticosus [1].
The extracts from different parts of ES have been con-
sidered good for health [21]. The ES antioxidant effect is
related to improvements in the treatment of diabetes,
cancer and inflammatory state, in addition to their immu-
noregulatory and immunomodulatory property, and anti-
microbial and antiviral activity [11].
Six secondary compounds found in Eleutherococcus
senticosus have demonstrated antioxidant effects (such as
siringina, caffeic acid, ethyl aldehyde, coniferyl alde-
hyde), four had antioxidant effects in cancer (sesamin, β-
sitosterol, isofraxidine), and three had hypocholesterole-
mic activities (sesamin, β-sitosterol and β-sitosterol 3-D-
glucoside) [15].
Sesamin and siringina demonstrated immunostimula-
tory activity, while isofraxidine showed choleretic activ-
ity. Siringina demonstrated radioprotective property, and
antibacterial activity of caffeic acid [15].
The hypocholesterolemic activity of sesamin, β-sitos-
terol compounds and its glycoside β-sitosterol β-D-glu-
copyranoside can be explained by their participation in
antioxidant reactions on LDL (low density lipoprotein),
Copyright © 2013 SciRes. OPEN ACCESS
A. Arouca, D. M. Grassi-Kassisse / Health 5 (2013) 1509-1515
Copyright © 2013 SciRes. OPEN ACCESS
1511
Table 1. Effects of some types of ginseng on physical performance in humans.
Ginseng Experimental design Results
Standardized extract of Panax ginseng 200
mg/day, during 9 weeks.
[28]
Men, n = 20, data collected-aerobic
capacity. Increased aerobic capacity, reduced
lactate production and heart rate.
Standardized extract of Panax ginseng containing
4% or 7% of ginsenosides, during 9 weeks.
[29]
Young men, n = 30, data
collected-aerobic capacity
Improved aerobic capacity, reduced lactate
production and heart rate, there was no
difference between 4% and 7% of the
content of ginsenosides.
Standardized extract of Panax ginseng 200
mg/day, during 9 weeks.
[30]
High performance athletes, n = 30,
data collected-O2 uptake.
Improved O2 uptake, maximum breathing
capacity, vital capacity and forced expiratory
volume, reduced lactate production and
heart rate; no significant changes for
serum LH, testosterone, and cortisol.
Glycosides, 2000 mg/day; 1.5%, during 4 weeks.
[31] Marathon runners, n = 12, data
collected-aerobic capacity.
No significant difference on the running time
to exhaustion, aerobic capacity, heart rate,
VE, and RPE.
Standardized extract of ARM229, 2 capsules per
30 days; 1 capsule per 30 days.
[32]
Young people (18 - 21 years), and
adults (38 - 70 years), n = 65, data
collected-performance in Cooper Test.
In the adult group, there was an improved
performance in the Cooper test (12 min race),
and in the young group there was no
significant difference.
Standardized extract of P. ginseng (G115), 200
mg/day, during 9 weeks.
[33]
High performance athletes, n = 28,
data collected-effects on the
health of athletes.
Improved O2 uptake, forced expiratory
volume, vital capacity, reaction time
and heart rate.
E. senticosus M, during 8 days.
[34] Young men, n = 6, data collected-maximal
work capacity. Significant increase in total work,
time to exhaustion
Chinese ginseng and Eleutherococcus senticosus,
during 6 weeks.
[35]
Marathon runners, n = 15 (M) and n = 15 (W),
data collected-aerobic performance,
physical strength.
Significant increase in VO2max,
physical strength.
Ginseng and fenu-greco 0.5 g twice a day, during
15 days.
[36]
Young men, n = 12, data
collected-strength and muscle fatigue.
Significant increase in the production of
work, significant differences in
the lactate level.
Ginseng and fenu-greco 0.5 g twice a day, during
30 days.
[37]
Well-trained amateur cyclists, n = 14, data
collected-training, endurance performance.
Significant increase in anaerobic threshold,
blood ferritin, work, RER, VEmax,
VO2max; blood lactate is not significant.
Standardized extract of P. ginseng, 200 mg/day,
DMAE, vitamins, minerals, during 6 weeks.
[38]
People (21 - 47 years), n = 50, data
collected-work and aerobic capacity.
Improved the total workload, time to
exhaustion, aerobic capacity, ventilation,
VO2, carbon dioxide production, lactate
production and heart rate; no significant RER.
Standardized extract of P. ginseng, 400 mg/day
during 20 weeks.
[39]
Female triathletes (24 - 36 years, n = 43),
data collected-physical performance. Prevented the decrease in the physical
performance after 10 km.
P. ginseng C.A. Meyer 200 mg/day at 4%
ginsenosides, during 8 weeks.
[40]
Healthy adult women, n = 19, data
Collected-Metabolic responses. No significant difference in the sub
maximal and maximal exercise.
E. senticosus M 3.4 mL during 8 weeks.
[41]
People trained in distance running, n = 20,
data collected-Maximal and sub
maximal aerobic exercise.
No significant difference in the heart rate,
VO2, VE, VE/VO2, RER, RPE, time to
exhaustion and lactate level.
P. ginseng C.A. Meyer 200 mg/day at 4%
ginsenosides during 8 weeks.
[42]
Healthy adult women, n = 19, data
collected-work performance and
energy metabolism.
No significant difference in the performance of
maximum work, rest, exercise, recovery of O2,
RER, VE, heart rate, blood lactate levels.
Standardized extract of P. ginseng, vitamins,
minerals, 200 mg/day during 12 weeks.
[43]
Volunteers (18 - 65 years), n = 625,
data collected-quality of life. Improved quality of life, preventing
weight gain and increased blood pressure.
P. quinquefolium 8 or 16 mg/Kg/ day during 7
days.
[44]
Well-trained amateur cyclists, n = 7 (M), n = 1
(W), data collected-exhaustion at 75% VO2 max
There was no significant difference
in time to exhaustion, lactate levels and
glucose, RPE, VE, VO2
A. Arouca, D. M. Grassi-Kassisse / Health 5 (2013) 1509-1515
1512
Continued
P. ginseng C.A. Meyer 200 ou 400 mg/day,
during 8 weeks.
[45]
Healthy adult men, n = 31, data
collected-psychological and
physiological responses.
No significant difference in maximal
and submaximal O2 uptake, RER, VE,
blood lactate, heart rate and RPE.
Ginseng not especified 3 g/day, during 13 days.
[46]
Well-trained amateur cyclists, n = 7 (M) and
n = 4 (W), data collected-aerobic
exercise maximum.
There was no significant difference in
maximal heart rate, VO2max, workload,
RER.
P. ginseng 200 mg/day, 7% ginsenosides, during
3 weeks.
[47]
Moderately trained healthy young adults,
n = 20 (M) and n = 8 (W), data
collected-maximum aerobic performance.
There was no significant difference in VO2,
workload, exercise time, lactate, levels of
hematocrit, heart rate, RPE.
E. senticosus 1200 mg/day, during 7 days before
data collection
[3]
Well-trained men, n = 10, data
collected-substrate utilization,
maintenance of performance.
No significant difference in VO2, RER, RPE,
rate, heart rate, level of lactate and glucose.
P. ginseng C.A. Meyer 400 mg/day, during 8
weeks.
[48]
Healthy adult women, n = 24, data
collected-aerobic capacity, fatigue. There was no significant difference in the
supramaximal work of short duration.
Extract fluid of Taiga Wurzel-25 drops 3 x/day (1
mL equivalent to 1 g root) during 30 days.
[8]
Healthy volunteers (n = 50, W and M),
data collected-total cholesterol, LDL
cholesterol, free fatty acids,
triacylglycerol, glucose, VO2max.
Significant reduction in total cholesterol and
LDL cholesterol levels, reduction of free
fatty acids, triacylglycerol, blood glucose,
and significant increase in peak VO2max.
Panax not ginseng
1350 mg/day, during 30 days.
[49]
Young adults, n = 29, data collected-aerobic
capacity, endurance, mean arterial
pressure and VO2.
Significant improvement in endurance,
time to exhaustion, decrease in the mean
arterial pressure and VO2.
Standardized extract of E. senticosus
800 mg/day, during 8 weeks.
[20]
Men in recreational cycling training, n = 9,
data collected-aerobic capacity, maximum
heart rate, VO2, RPE, RER, free fatty acids
and glucose in the plasma.
Significant increase in peak VO2, heart rate
and improvement in endurance time. The
production of free fatty acids in the plasma
was increased, and the glucose level
decreased significantly (P < 0.05) in 30 min
within 75% of peak VO2.
Panax ginseng
200 mg, 1 hour before running on a treadmill,
acute study.
[50]
Recreational athletes racing (n = 9, 25 - 32
years), data collected-aerobic capacity, VO2,
heart rate, body temperature, RPE, glucose,
lactate, plasma insulin, free fatty acids.
Acute supplementation did not affect any
of the parameters analyzed in the study.
Korean ginseng extract, 20 g, mixed with 200 mL
of water 3x/day, during 7 days before the test, and
four days after the test.
[51]
Male college students, n = 18, data
Collected-Exercise-induced muscle
damage, inflammatory response,
insulin sensitivity.
Significant decrease in creatine kinase and
interleukin 6 in the group supplemented
with ginseng, and a significant decrease in
plasma insulin and glucose, suggesting
reduced muscle damage and decreased
inflammatory response, resulting in
improvements in insulin sensitivity.
W = women; M = men; O2 = oxygen; RER = respiratory exchange ratio; RPE = rate of perceived exertion; VE = expiratory volume; VEmax = forced expiratory
volume; VO2 = oxygen uptake; VO2max = maximum oxygen uptake; LH = luteinizing hormone, n = number of volunteers. Reference number between [ ],
Source: Adapted and updated from Barke & Morgan [2] and Bucci [52].
and also, the sesamin has a direct effect on cholesterol
re-synthesis. β-sitosterol also has an important effect on
the cholesterol structure, reducing its absorption (as de-
monstrated in humans) and the ability to reduce insulin
concentrations, as well as and antioxidant effects regard-
ing cancer. β-sitosterol also has anti-inflammatory and
antipyretic activities [15].
The antihyperglycaemic action of β-sitosterol and its
glycoside can be explained by the competitive enzyme in-
hibition in glucose breakdown, but it does not end the
possibilities for this property [15].
The study by Rhie and Won (2004) [22] demonstrated
the potent effect on body weight gain of mice treated with
ES, which was significantly reduced, besides demon-
strating a significant reduction in the plasmatic choles-
terol concentration. One hypothesis for this important ef-
fect in reducing weight could be explained by the action of
ES on glucose and insulin metabolism [20], besides the ef-
fect of lower concentrations of corticosterone in rats [11,23].
4. ADVERSE EFFECTS OF
ELEUTHEROCOCCUS
SENTICOSUS
A case was reported on the use of Eleutherococus sen-
ticosus in a man who used digoxin and who had high
plasmatic concentration (digoxin). When the supplemen-
Copyright © 2013 SciRes. OPEN ACCESS
A. Arouca, D. M. Grassi-Kassisse / Health 5 (2013) 1509-1515 1513
tation was interrupted, the plasmatic concentration de-
creased [24]. Diabetics who use ES should monitor blood
glucose concentrations, due to the hypoglycemic effects
reported in animals [25].
5. TOXICOLOGICAL EFFECTS
The safety and efficacy of the ES supplement were
evaluated on the activities of CYP2D6 of the cytochrome
P450 and CYP3A4 [26], suggesting that the ES extract at
a dose as it is usually recommended does not affect the
metabolism of CYP2D6 and CYP3A4, and, therefore, it is
not harmful to the health of individuals [11,27].
6. CONCLUSION
ES may receive great attention by showing that its ac-
tive components can provide protection against oxidative
stress, among other benefits, contributing to health and
the prevention and treatment of diseases such as diabetes,
cancer, cardiovascular disease and inflammations. How-
ever, the researches comprise mostly in vitro tests or ani-
mals tested in vivo in the laboratory, and the studies may
not necessarily apply to humans. When they apply, there
may be no reliable results due to factors such as diet, life-
style, exercise and the administration of other drugs, and
also the actual health of the participants. Nevertheless, it
is expected that further controlled studies in humans are
performed for a better understanding of the ES effects and
its implementation, conferring it an economic importance,
since it may help in the treatment of several diseases.
REFERENCES
[1] Goulet, E.D.B. and Dionne, I.J. (2005) Assessment of the
effects of Eleutherococcus senticosus on endurance per-
formance. International Journal of Sport Nutrition and
Exercise Metabolism, 14, 75-83.
[2] Bahrke, M.S., Morgan, W.P. and Stegner, A. (2009) Is Gin-
seng an ergogenic aid? International Journal of Sport
Nutrition and Exercise Metabolism, 19, 298-322.
[3] Eschbach, L.C., Webster, M.J., Boyd, J.C., McArthur, P.D.
and Evetovich, T.K. (2000) The effect of Siberian ginseng
(Eleutherococcus senticosus) on substrate utilization and
performance during prolonged cycling. International Jour-
nal of Sport Nutrition and Exercise Metabolism, 10, 444-
451.
[4] Brekhman, I.I. and Dardymov, I.V. (1969) New sub-
stances of plant origin which increase nonspecific resis-
tance. Annual Review of Pharmacology and Toxicology, 9,
419-430. doi:10.1146/annurev.pa.09.040169.002223
[5] Bahrke, M.S. and Morgan, W.P. (2000) Evaluation of the
ergogenic properties of ginseng. Sports Medicine, 2, 113-
133. doi:10.2165/00007256-200029020-00004
[6] Fu, Y. and Ji, L.L. (2003) Chronic Ginseng consumption
attenuates age-associed oxidative stress in rats. Journal of
Nutrition, 11, 3603-3609.
[7] Atelle, A.S., Wu, J.A. and Yuan, C. (1999) Ginseng phar-
macology, multiple constituents and multiple actions. Bi-
ochemical Pharmacology, 58, 1685-1693.
doi:10.1016/S0006-2952(99)00212-9
[8] Szolomicki, J., Samochowiec, L., Mójcicki, J. and Droz-
dzik, M. (2000) The influence of active components of
Eleutherococcus senticosus on cellular defense and phy-
sical fitness in man. Phytotherapy Research, 14, 30-35.
doi:10.1002/(SICI)1099-1573(200002)14:1<30::AID-PT
R543>3.3.CO;2-M
[9] Baranov, A.I. (1982) Medicinal uses of ginseng and relat-
ed plants of the Soviet Union: Recent trends in the Soviet
literature. Journal of Ethnopharmacology, 6, 339-353.
doi:10.1016/0378-8741(82)90055-1
[10] (2010) Official Journal of the European Union, 53.
http://eur-lex.europa.eu/JOHtml.do?uri=OJ%3AL%3A20
10%3A012%3ASOM%3AEN%3AHTML
[11] Yan-Lin, S., Lin-De, L. and Soon-Kwan, H. (2011) Eleu-
therococcus senticosus as a crude medicine: Review of
biological and pharmacological effects. Journal of Me-
dicinal Plants Research, 5, 5946-5952.
http://www.academicjournals.org/JMPR
[12] Elyakov, G.B., Strigina, L.I., Uvarova, N.I., Vaskovsky,
V.E., Dzizenko, A.K. and Kochetkov, N.K. (1964) Glyco-
sides from ginseng roots. Tetrahedron Letters, 48, 3591-
3597. doi:10.1016/S0040-4039(01)89378-3
[13] Hikino, H., Takahashi, M., Otake, K. and Konno, C. (1986)
Isolation and hypoglycemic activity of eleutherans A, B,
C, D, E, F, and G: Glycans of Eleutherococcus senticosus
roots. Journal of natural products, 49, 293-297.
doi:10.1021/np50044a015
[14] Wagner, H., Norr, H. and Winterhoff, H. (1994) Plant adap-
togens. Phytomedicine, 1, 63-76.
doi:10.1016/S0944-7113(11)80025-5
[15] Davydov, M. and Krikorian, A.D. (2000) Eleutherococcus
senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an
adaptogen: A closer look. Journal of Ethnopharmacology,
72, 345-393. doi:10.1016/S0378-8741(00)00181-1
[16] Yat, P.N., Arnason, J.T. and Awang, D.V.C. (1998) An im-
proved extraction procedure for the rapid, quantitative
high-performance liquid chromatographic estimation of the
main eleutherosides (B and E) in Eleutherococcus (Eleu-
thero). Phytochemical Analysis, 9, 291-295.
doi:10.1002/(SICI)1099-1565(199811/12)9:6<291::AID-
PCA417>3.0.CO;2-K
[17] Apers, S., Naessens, T., Van Miert, S., Pieters, L. and Vli-
etinck, A. (2005) Quality control of roots of Eleuthero-
coccus senticosus by HPLC. Phytochemical Analysis, 16,
55-60. doi:10.1002/pca.811
[18] Campbell, T.C., Wu, Y.N., Lu, C.Q., Li, M. and Kaman,
R.L. (1997) Effects of Radix Acanthopanax senticosus
(ciwujia) on exercise. The Journal of Strength & Condi-
tioning Research, 11, 278.
[19] Wu, Y.I.N., Wang, X.Q., Zhao, Y.F., Wang, J.Z., Chen, H.J.,
Liu, H.Z., Li, R.W., Campbell, T.C. and Chen, J.S. (1996)
Effect of ciwujia (Radix Acanthopanax senticosis) prepa-
ration on human stamina. Wei Sheng Yan Jiu, 25, 57-61.
[20] Kuo, J., Chen, K.W.C., Cheng, I.S., Tsai, P.H., Lu, Y.J. and
Copyright © 2013 SciRes. OPEN ACCESS
A. Arouca, D. M. Grassi-Kassisse / Health 5 (2013) 1509-1515
1514
Lee, N.Y. (2010) The effect of eight weeks of supplemen-
tation with Eleutherococcus senticosus on endurance ca-
pacity and metabolism in human. The Chinese Journal of
Physiology, 53, 105-111. doi:10.4077/CJP.2010.AMK018
[21] Han, J.H., Jung, I.C., Cho, H.E. and Park, S.H. (2006) To-
tal polyphenol, water soluble antioxidants contents and
antioxidative activity from a composite with Eleuthero-
coccus senticosus and several oriental medicine herbs.
Korean Journal of Oriental Physiology & Pathology, 20,
1275-1281.
[22] Rhie, S.G. and Won, H.R. (2004) Effect of hot water so-
luble extract from Eleutherococcus senticosus and dietary
carnitine on the lipid metabolism and antioxidant defense
system of rats on hypercholesterol diet. The Korean Jour-
nal of Community Living Science, 15, 105-113.
[23] Kimura, Y. and Sumiyoshi, M. (2004) Effects of various
Eleutherococcus senticosus cortex on swimming time, na-
tural killer activity and corticosterone level in forced swim-
ming stressed mice. Journal of Ethnopharmacology, 95,
447-453. doi:10.1016/j.jep.2004.08.027
[24] Huang, L.Z., Zhao, H.F., Huang, B.K., Zheng, C.J., Peng,
W. and Qin, L.P. (2011) Acanthopanax senticosus: Review
of botany, chemistry and pharmacology. Pharmazie, 66,
83-97.
[25] Brinker, F. (1998) Herb contraindications and drug inte-
ractions. 2nd Edition, Eclectic Medical Publications, Sany,
123.
[26] Brosen, K. (1996) Drug-metabolizing enzymes and thera-
peutic drug monitoring in psychiatry. Therapeutic Drug
Monitoring, 18, 393-396.
doi:10.1097/00007691-199608000-00014
[27] Donovan, J.L., Devane, C.L., Chavin, K.D., Taylor, R.M.
and Markowitz, J.S. (2003) Siberian ginseng (Eleuthero-
coccus senticosus) effects on CYP2D6 and CYP3A4 ac-
tivity in normal volunteers. Drug Metabolism and Dispo-
sition, 31, 519-522. doi:10.1124/dmd.31.5.519
[28] Forgo, I. and Kirchdorfer, A.M. (1981) Ginseng steigert
die körperliche Leistung. Kreislaufphysiologische Unter-
suchungen an Spitzensportlern beweisen: Der Stoffwech-
sel wird aktiviert. (On the question of influencing the per-
formance of top sportsmen by means of biologically ac-
tive substances). Arztl Prax, 33, 1784-1791.
[29] Forgo, I. and Kirchdorfer, A.M. (1982) The effect of dif-
ferent ginsenoside concentrations on physical work capa-
city. Notabene Medicine, 12, 721-727.
[30] Forgo, I. (1983) Effect of drugs on physical performance
and the hormonal system of athletes. MMW: Munchener
Medizinische Wochenschrift, 125, 822-824.
[31] Teves, M.A., Wright, J.E., Welch, M.J., Patton, J.F., Mel-
lo, R.P., Rock, P.B., Knapik, J.J., Vogel, J.A. and derMar-
derosian, A. (1983) Effects of ginseng on repeated bouts
of exhaustive exercise. Medicine & Science in Sports &
Exercise, 15, 162.
doi:10.1249/00005768-198315020-00350
[32] Murano, S. and Lo Russo R. (1984) Experiencia con ARM
229. Prensa Medical Argent, 71, 178-183.
[33] Forgo, I. and Schimert, G. (1985) The duration of effect of
the standardized ginseng extract G115 in healthy compe-
titive athletes. Notabene Medicine, 15, 636-640.
[34] Asano, K., Takahashi, T., Miyashita, M., Matsuzaka, S.,
Muramatsu, S., Kuboyama, M., Kugo, H. and Imia, J.
(1986) Effect of Eleutherococcus senticosus extract on hu-
man physical working capacity. Planta Medica, 3, 175-
177. doi:10.1055/s-2007-969114
[35] McNaughton, L., Egan, G. and Caelli, G. (1989) A compa-
rison of Chinese and Russian ginseng as ergogenic aids to
improve various facets of physical fitness. International
Journal of Clinical and Nutrition Reviews, 9, 32-35.
[36] Gribaudo, C.G., Ganzit, G.P. and Verzini, E.F. (1990) Ef-
fetti sulla forza e sulla fatica muscolare di un prodotto er-
gogenico di origine naturale. Medicina Dello Sport, 43,
241-249.
[37] Gribaudo, C.G., Ganzit, G.P., Biancotti, P.P. and Meda, C.
(1991) Effetti della soministrazione di un prodotto natu-
ralle ergogenico sulle doti aerobiche di ciclisti agonisti.
Medicina Dello Sport, 44, 335-343.
[38] Pieralisi, G., Ripari, P. and Vecchiet, L. (1991) Effects of
a standardized ginseng extract combined with dimethyl-
aminoethanol bitartrate, vitamins, minerals, and trace
elements on physical performance during exercise. Clini-
cal Therapy, 13, 373-382.
[39] Van Schepdael, P. (1993) Les effets du ginseng G115 sur
la capacité physique de sportifs d’endurance. Acta Thera-
peutica, 19, 337-347.
[40] Engels, H.-J., Said, J.M., Wirth, J.C. and Zhu, W. (1995)
Effect of chronic ginseng intake on metabolic responses
during and in the recovery from graded maximal exercise
(abstract). Medicine & Science in Sports & Exercise, 27,
S147. doi:10.1249/00005768-199505001-00830
[41] Dowling, E.A., Redondo, D.R., Branch, J.D., Jones, S.,
McNabb, G. and Williams, M.H. (1996) Effect of Eleu-
therococcus senticosus on submaximal and maximal ex-
ercise performance. Medicine & Science in Sports & Ex-
ercise, 28, 482-489.
doi:10.1097/00005768-199604000-00013
[42] Engels, H.-J., Said, J.M. and Wirth, J.C. (1996) Failure of
chronic ginseng supplementation to affect work perfor-
mance and energy metabolism in healthy adult females.
Nutrition Research, 16, 1295-1305.
doi:10.1016/0271-5317(96)00138-8
[43] Marasco, C., Vargas, R., Villagomez, S. and Infante, B.
(1996) Double-blind study of a multivitamin complex
supplemented with ginseng extract. Drugs under Experi-
mental and Clinical Research, 22, 323-329.
[44] Morris, A.C., Jacobs, I., McLellan, T.M., Klugerman, A.,
Wang, L.C.H. and Zamecnik, J. (1996) No ergogenic ef-
fect of ginseng ingestion. International Journal of Sport
Nutrition, 6, 263-271.
[45] Engels, H.J. and Wirth, J.C. (1997) No ergogenic effects
of ginseng (Panax ginseng C.A. Meyer) during graded
maximal aerobic exercise. Journal of the American Die-
tetic Association, 97, 1110-1115.
doi:10.1016/S0002-8223(97)00271-X
[46] Lifton, B., Otto, R.M. and Wygand, J. (1997) The effect
of ginseng on acute maximal aerobic exercise (abstract).
Medicine & Science in Sports & Exercise, 29, 249.
doi:10.1097/00005768-199705001-01413
Copyright © 2013 SciRes. OPEN ACCESS
A. Arouca, D. M. Grassi-Kassisse / Health 5 (2013) 1509-1515
Copyright © 2013 SciRes. OPEN ACCESS
1515
[47] Allen, J.D., McLung, J., Nelson, A.G. and Welsch, M.
(1998) Ginseng supplementation does not enhance heal-
thy young adults’ peak aerobic exercise performance.
Journal of the American College of Nutrition, 17, 462-
466. doi:10.1080/07315724.1998.10718795
[48] Kolokouri, I., Engels, H.-J., Cieslak, T. and Wirth, J.C.
(1999) Effect of chronic ginseng supplementation on
short duration, supramaximal exercise test performance.
Medicine & Science in Sports & Exercise, 31, S117.
doi:10.1097/00005768-199905001-00445
[49] Liang, M.T., Podolka, T.D and Chuang, W.J. (2005) Pa-
nax not ginseng supplementation enhances physical per-
formance during endurance exercise. Journal of Strength
& Conditioning Research, 19, 108-114.
doi:10.1519/00124278-200502000-00019
[50] Ping, F.W., Keong, C.C. and Bandyopadhyay, A. (2011)
Effects of acute supplementation of Panax ginseng on
endurance running in a hot & humid environment. Indian
Journal of Medical Research, 133, 96-102.
[51] Jung, H.L., Kwak, H.E., Kim, S.S., Kim, Y.C., Lee, C.D.,
Byurn, H.K. and Kang, H.Y. (2011) Effects of Panax
ginseng supplementation on muscle damage and inflame-
mation after uphill treadmill running in humans. The
American Journal of Chinese Medicine, 39, 441-450.
doi:10.1142/S0192415X11008944
[52] Bucci, L.R. (2000) Selected herbals and human exercise
performance. The American Journal of Clinical Nutrition,
72, 624-636.
... This plant known as Acanthopanax senticosus, Ciwujia, Siberian ginseng is a member of the family Araliaceae. It grows in eastern regions of Russia and the northern areas of Japan,Korea, and China [50]. The chief ingredients of this plant are mainly found in roots and typically consist of glycosides called eleutherosides. ...
... This plant known as Acanthopanax senticosus, Ciwujia, Siberian ginseng is a member of the family Araliaceae. It grows in eastern regions of Russia and the northern areas of Japan, Korea, and China [50]. The Table 1 Herbal Extract Acting on Osteoblast. ...
... The Flemingia macrophylla ethanolic extract inhibits osteoclast differentiation in vitro. It was found that oral administration (50,250, 500 mg/kg daily) for 13 weeks reduces bone loss in OVX rats [110]. The stem and leaves are used as an anti-inflammatory, blood circulation promotion, and antidiabetic agent [109]. ...
Article
Full-text available
Postmenopausal osteoporosis, an epidemic disorder is defined as a loss in bone mineral density and a greater possibility of fractures in older women. It is a multifactorial disease under the control of various genetic, hormonal, and environmental factors. Insufficiency of estrogen hormone, leads to postmenopausal osteoporosis. Hormone replacement therapy (HRT), despite being the most effective treatment, it is associated with the risk of breast cancer and cardiovascular disorders. This review seeks to compile the most recent information on medicinal plants and natural compounds used to treat and prevent postmenopausal osteoporosis. Furthermore, the origin, chemical constituents and the molecular mechanisms responsible for this therapeutic and preventive effect are also discussed. Literature research was conducted using PubMed, Science direct, Scopus, Web of Science, and Google Scholar. Different plant extracts and pure compounds exerts their antiosteoporotic activity by inhibition of RANKL and upregulation of OPG. RANKL signaling regulates osteoclast formation, characterized by increased bone turnover and osteoprotegrin is a decoy receptor for RANKL thereby preventing bone loss from excessive resorption. In addition, this review also includes the chemical structure of bioactive compounds acting on NFκB, TNF α, RUNX2. In conclusion, we propose that postmenopausal osteoporosis could be prevented or treated with herbal products.
... E. senticosus or Acanthopanax (Siberian ginseng) roots contained relatively high levels of essential trace elements and minerals like Zn, Cu, I, B, and Ca, as well as substantial amounts of toxic Cd and Ni. Although certain researchers propose that the level of trace elements in eleutherococcus mediates a part of its biological activity [54], quantitative data on trace elements content in E. senticosus roots are scarce. Earlier studies revealed substantial levels of essential trace elements in E. senticosus leaves [33] and fruits [55]. ...
Article
Full-text available
The objective of the present study was to assess the patterns of trace element and mineral accumulation in 21 medicinal plants collected in the Altai Mountains foothills. The levels of trace elements and minerals in Hippophae rhamnoides, Aronia melanocarpa, Sorbus aucuparia, Viburnum opulus, Rosa canina, Crataegus sanguinea (fruits), Chamaenerion angustifolium, Echinacea purpurea, Fagopyrum esculentum, Trifolium pratense, Origanum vulgare, Achillea millefolium, Mentha piperita (herbs), Plantago major, Salvia officinalis, Urtica dioica (leaves), Panax ginseng, Rhaponticum carthamoides, Eleuterococcus senticosus, and Taraxacum officinale (roots), and Matricaria recutita flowers were assessed using inductively-coupled plasma mass-spectrometry. Comparative analysis revealed that R. carthamoides roots accumulated the highest level of toxic trace elements (Al, Cd, Ni, Pb). C. angustifolium herbs and V. opulus fruits are characterized by the highest As and Sn levels, respectively. The highest content of essential trace elements and minerals was observed in H. rhamnoides fruits (Zn), V. opulus fruits (Cu), E. purpurea herbs (I, Mg), R. carthamoides roots (Fe), O. vulgare herbs (Mn), and M. recutita herbs (Se). In turn, R. canina fruits are characterized by the lowest levels of certain essential and toxic trace elements. Significant differences in B, Cr, Li, Si, and Sr content were also revealed. Discriminant analysis revealed complete discrimination of certain medicinal plants based on their trace element and mineral content. The obtained data indicate the potential usefulness of medicinal plants as sources of certain essential trace elements and minerals, as well as provides data for risk assessment of toxic trace element intake following administration of medicinal plants.
... On the other hand, ESC, also known commonly as "Siberian ginseng", is a species in the Araliaceae family whose fruits and stems are widely known for their therapeutic properties. Several studies have reported the health benefits of MAB and ESC for the treatment of oxidative stress-related diseases such as diabetes, cancer, and inflammation, suggesting that these plants possess strong antioxidant properties (Kim et al. 1999b(Kim et al. , 2005Arouca and Grassi-Kassisse 2013;Chan et al. 2016). ...
Article
Full-text available
This study evaluated the in vitro radical scavenging activities of edible tree sprouts, particularly those of the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), hydroxyl radical, and singlet oxide radical, to assess their antioxidant activities. Additionally, stigmasterol (ST) and β-sitosterol (BS) were analyzed using HPLC/UV. The edible sprouts of Eleutherococcus senticosus (ESC) and Morus alba (MAB) exhibited the highest DPPH scavenging activity among other edible sprouts. A reverse-phase column was used in an isocratic elution system, after which UV detection was performed at 210 nm. ST and BS analyses indicated that ESC sprouts contained the highest amounts of ST (9.99 mg·g− 1 extract), whereas MAB sprouts contained the highest concentrations of BS (14.69 mg·g− 1 extract). In conclusion, the highest antioxidant activity was observed in the edible sprouts with the highest phytosterol content. Therefore, our findings provide a theoretical basis for the development of plant-based functional foods or supplements with antioxidant properties.
... Because of the lack of standardization for cultivation, some E. senticosus appeared in a poor quality at China market. It has been confirmed that 26% of the products did not meet the content of the compounds described on the label (Arouca and Grassi-Kassisse 2013). So, studying the appropriate cultivation conditions of E. senticosus has an essential significance for controlling the quality of this medicinal plant. ...
Article
Full-text available
In this investigation, we used the growth, photosynthetic physiological parameters, and targeted metabolite analysis to evaluate the responses of Eleutherococcus senticosus in different shading treatments. The results showed that the moderate shading treatment (Z1) promoted the growth and inhibited photosynthesis of plants. The severe shading treatment (Z2)inhibited both the growth and photosynthesis of the plants. Besides, Z1 had no significant effect on the PSII, while Z2 inhibited the PSII. Most of the eight medicinal metabolites accumulated in the Z1. The C6C1- and C6C3-type phenolics accumulated in the Z1, and the C6C3C6-type in the Z2. In conclusion, the moderate shading treatment accumulated more defensive phenolics; this might be the reason for this shading condition promoting the growth and the accumulation of medicinal metabolites of the plant. The result of this study laid a theoretical foundation for the further study of shading treatments on the secondary metabolism of Eleutherococcus senticosus.
... Because of a lack of the assessment of plant material, there have been cases of the poor quality of plants supplied by Chinese traders. It was confirmed that 26% of products prepared, among other, from E. senticosus did not meet label claims with respect to the claimed constituents content, as well as substitution of Periploca sepium Bunge for E. senticosus has been well documented (Arouca & Grassi-Kassisse 2013;Fong 2002). This is particularly important in the pharmaceutical drug development process and to avoid that, the establishment of the new source of important medicinal plants in Europe is required. ...
Article
Full-text available
Neither secondary metabolites of the spring leaves nor the autumn leaves of Eleutherococcus senticosus species cultivated in Poland, or the bioactivity are known. The richest in polyphenols were the autumn leaves (171.1 mg/g DE), while in flavonoids the spring leaves (107.9 mg/g DE). Using LC-ESI-MS/MS, protocatechuic acid has been identified as the most abundant compound in the spring and autumn leaves (200 and 70 µg/g DE, respectively). Amongst flavonoids, naringenin 7-O-glucoside occurred in the largest amount (20 and 10 mg/g DE in the spring and autumn leaves, respectively). The autumn leaves inhibited Hyal the strongest (74.3%), comparing to the spring leaves (33%). A weak inhibition was found towards AChE (0.64 and 5.8% for the autumn and spring leaves, respectively). To our best knowledge, no information was available on the phytochemical composition and activity of the leaves of Eleutherococcus senticosus cultivated in Poland.
Article
Rhodiola rosea and Eleutherococcus senticosus are widely studied adaptogens, often consumed as herbal tea or supplements. However, further insights into their roots are needed to expand their applications. The aim of this study was to examine their proximate composition and the impact of processing conditions (pH and temperature) on their bioactive compounds. The results revealed that both roots are abundant sources of fibre, particularly E. senticosus (70.89 to 77.96 g/100 g). Moreover, rosavin and salidroside were highest in samples R3-R5, with concentrations ranging from 55 to 68 and 25 to 69 mg/g root, respectively. As for E. senticosus, eleutheroside E showed similar contents within samples (10–15 mg/g root). Optimal extraction occurred at pH 3–5 and 50 °C, except for rosavin and salidroside. The stability of most bioactive compounds under acidic and high-temperature conditions suggests that dried R. rosea and E. senticosus roots have potential for functional food development.
Article
Full-text available
Acanthopanax senticosus belongs to Araliaceae family and is traditionally used as a tonic. The roots and stems are mainly used as treatments for hypodynamia, rheumatism, and hypertension, but their frequent use may lead to extinction. However, comprehensive and simultaneous analysis of the remaining parts were still limited. There is a need to reorganize them for standardization of functional foods. In this study, 50 phenolic compounds and 82 triterpenoid saponins from the shoots, leaves, fruits, and stems of were characterized using UPLC-QTOF-MS and UPLC-QTRAP-MS/MS. Among them, 52 compounds were newly determined as the cis and malonyl-bound phenolic acids and were found to be structural isomers of Acanthopanax flavonoids and saponins. All compounds were absolutely/relatively quantified, and shoots had the highest content. Peroxynitrite and α-glucosidase inhibitory activities were performed, followed by evaluation of structure-activity relationships. Particularly, hederasaponin B and ciwujianoside B showed remarkable efficacy, which were affected by the C-23 hydroxylation, the C-20(29) double bond, and the presence of rhamnose. These detailed profiling can be used as fundamental data for increasing the utilization of A. senticosus and developing them into functional foods.
Article
Zengin geleneksel mirası ve çok yönlü uygulamaları nedeniyle bitkiler ve bitki kaynaklı bileşenler antik çağlardan günümüze kadar büyük ilgi görmüştür. Bu bitki kaynaklı bileşenler; geleneksel tıp sistemlerindeki ilaçların, modern ilaçların, nutrasötiklerin, gıda takviyelerinin, farmasötik ara maddelerin önemli kaynaklarıdırlar. Bitki kaynaklı ajanlar olarak bilinen adaptojenler; stresin zararlı etkilerinden koruyan, çevresel faktörlere uyum sağlama yeteneğimizi artıran ve hasarı azaltan doğal biyo düzenleyicilerdir. Adaptojenler hücresel adaptif sinyal yollarını aktive eden ve böylece dayanıklılığı, zorlu koşullara adaptasyonu ve hayatta kalma şansını spesifik olmayan şekilde artıran şifalı bitkiler, gıdalar ve fitokimyasallardır. Adaptojenler; strese karşı koymak, fiziksel direnci artırmak, formda kalmak veya yaşa bağlı gelişen hafıza ve dikkat kaybı, yorgunluk, uykusuzluk, kaygı, genel halsizlik, duygusal dengesizlik gibi bazı bozuklukları hafifletmek amacıyla kullanılır. Kısa ve uzun vadede zorlu durumlara karşı vücudun fizyolojik ve zihinsel stres tepkisini düzenlemeye ve azaltmaya yardımcı olurlar. Adaptojenler, adrenal bezlerden salgılanan hormonların salınımını kontrol ederek, fizyolojik ve zihinsel bir tepki olan stres tepkisini düzenlediklerinden sadece bir işlevi yerine getirmekle kalmazlar, aynı zamanda vücudun o an ne ile baş etmeye çalıştığına bağlı olarak salgılanan hormonları düzenleyerek semptomların hafifletilmesine ve azaltılmasına da yardımcı olurlar. Adaptojenlerin kortikosteroidler, katekolaminler ve nitrik oksit gibi stres aracılarına tepki olarak hareket ettiği ve diğer etkilerin yanı sıra spesifik olmayan bir şekilde antioksidan, immünomodülatör, hipoglisemik, hipokolesterolemik olarak da hareket edebildiği düşünülmektedir.
Chapter
Ovarian cancer, one of the three leading malignancies in women, has high incidence and mortality worldwide. It is hard to diagnose until very late stages and the 5-year survival rate is very low, due mostly to its distant metastasis. Chemotherapy is currently the most common treatment to inhibit cancer growth, but long-term use could result in resistance and tumor recurrence in addition to damages to normal tissues and functions of the patients. In order to achieve safe and curative effects against cancers, many investigators have focused their attention on traditional Chinese herbal medicines. Paclitaxel, a natural antitumor agent, has significant effects on advanced malignancies including ovarian cancer and is in the standard front-line treatment. Additional natural anticancer substances have continually been discovered for their high effectiveness and low side-effects in ovarian cancer prevention and therapy. In this chapter, we summarize recent work on a selected group of natural components, including lignans, ellagic acid, luteolin, mangiferin, and Acanthopanax senticosus, which have all been demonstrated to reduce the progress of epithelial ovarian cancer in a dose-depend manner, by both in vitro and in vivo experiments. The mechanisms of the anticancer activities by these natural components involve expression suppression of MMP2 and MMP9.
Article
Full-text available
The use of nutritional ergogenic aids containing Eleutherococcus senticosus (ES), a plant which is also known as ciwujia or Siberian ginseng, is relatively common among endurance athletes. Eleutherococcus senticosus has been suggested to improve cardiorespiratory fitness (CF) and fat metabolism (FAM) and, therefore, endurance performance (EP). This article reviews the studies that evaluated the effects of ES during endurance exercise, three of which suggest that ES substantially improves CF, FAM, and EP. However, each of these reports contains severe methodological flaws, which seriously threaten their internal validity, thereby rendering hazardous the generalization of the results. On the other hand, 5 studies that used rigorous research protocols show no benefit of ES on CF, FAM, and EP It is therefore concluded that ES supplementation (up to 1000 to 1200 mg/d for 1 to 6 wk) offers no advantage during exercise ranging in duration from 6 to 120 min.
Article
Eleutherosides were extracted with aqueous methanol and analysed by reversed-phase high performance liquid chromatography on a C-18 column. Recovery was better than 80% for eleutheroside B within the concentration range 500 to 10,000 μg, and similarly for eleutherosides E in the range 500 to 2500 μg. Lower recovery values were obtained at higher concentrations for eleutheroside E due to its insolubility in alcoholic solutions. The use of trifluoroacetic acid solution in methanol was found to resolve the solubility problem. The concentration ranges over which a linearity of response for both eleutherosides could be validated were improved significantly by this adjustment.
Article
Eleutherococcus senticosus (Rupr. et Maxim.) Harms (Acanthopanax senticosus, Araliaceae, ES, thereafter), also called Siberian ginseng, Ciwujia in Chinese, and Gasiogalpi in Korea, is distributed in the southeastern Russia, northeast China, Korea, and Japan. The woody medicinal plant has been known since ancient times for its curative properties, and particularly the cortical roots and stem tissues of ES have been utilized for the treatment of various ailments such as cancer, diabetes, cardiovascular diseases, hepatitis, spleen and liver complaints. Due to its giant therapeutic efficacy, more and more investigations have been carried out on the isolation and analysis of active compounds of ES, and their in vitro and in vivo pharmacological activities and even clinical effects in humans. This review, therefore, provides a comprehensive review of the pharmacologically relevant compounds of ES characterized so far and of the studies supporting its use as a medicinal plant. Particular attention has been given to anti-inflammatory, anti-oxidative, anti-carcinogenic, anti-fatigue, anti-diabetes, hypolipide, immunoprotection and immunoregulation, and antimicrobial and antiviral activities. This work presented here would help more detailed pharmacological cognition and further understanding of natural components of this medicinal plant species.
Article
Siberian ginseng ([SG]; Eleutherococcus senticosus) is a commonly used herbal preparation. The objective of this study was to assess in normal volunteers (n = 12) the influence of a standardized SG extract on the activity of cytochrome P450 CYP2D6 and 3A4. Probe substrates dextromethorphan (CYP2D6 activity) and alprazolam (CYP3A4 activity) were administered orally at baseline and again following treatment with SG (1 × 485 mg twice daily) for 14 days. Urinary concentrations of dextromethorphan and dextorphan were quantified, and dextromethorphan metabolic ratios (DMRs) were determined at baseline and after SG treatment. Likewise, plasma samples were collected (0–60 h) for alprazolam pharmacokinetics at baseline and after SG treatment to assess effects on CYP3A4 activity. Validated high performance liquid chromatography methods were used to quantify all compounds and relevant metabolites. There were no statistically significant differences between pre- and post-SG treatment DMRs indicating a lack of effect on CYP2D6 (P > 0.05). For alprazolam there also were no significant differences in the pharmacokinetic parameters determined by noncompartmental modeling (Cmax, Tmax, area under the curve, half-life of elimination) indicating that SG does not significantly induce or inhibit CYP3A4 (P > 0.05). Our results indicate that standardized extracts of SG at generally recommended doses for over-the-counter use are unlikely to alter the disposition of coadministered medications primarily dependent on the CYP2D6 or CYP3A4 pathways for elimination.