The general principles of pharmacological disposition apply almost universally to compounds which are foreign to the mammalian organism, including antineoplastic and immunosuppressive agents. Thus, the interrelated mechanisms of absorption, binding, distribution, metabolism, and excretion are the chief factors that determine the effective concentration of a drug at a receptor site (Fig. 1). In
... [Show full abstract] this chapter, a brief consideration is given to those processes which regulate the response of an organism to several commonly used antineoplastic and immunosuppressive agents. Excluded is the more complex process of metabolism since this aspect of pharmacological disposition is considered in two later chapters, and also in the chapters dealing with individual agents.
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