Practicability of Pharmacogenetics in Transplantation Medicine

1] Departments of Hospital Pharmacy [2] Internal Medicine.
Clinical Pharmacology &#38 Therapeutics (Impact Factor: 7.9). 08/2013; 95(3). DOI: 10.1038/clpt.2013.169
Source: PubMed


Implementation of pharmacogenetics in transplantation medicine is below the expectations expressed fifteen years ago. Numerous papers reported associations between gene polymorphisms and pharmacokinetics of immunosuppressive drugs. Evidence that genotype-based dosing improves outcome is lacking. Extensive therapeutic drug monitoring (TDM) can rapidly correct for the variability in drug exposure caused by genetic differences. The contribution of genotype-based dosing will be more pronounced for drugs for which pharmacokinetic or pharmacodynamic monitoring is not applied.Clinical Pharmacology & Therapeutics (2013); accepted article preview online 29 August 2013 doi:10.1038/clpt.2013.169.

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Available from: Dennis A Hesselink, Mar 22, 2014
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