Regulation of flavivirus RNA synthesis and capping

Department of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
WIREs RNA (Impact Factor: 6.02). 08/2013; 4(6). DOI: 10.1002/wrna.1191
Source: PubMed


RNA viruses, such as flaviviruses, are able to efficiently replicate and cap their RNA genomes in vertebrate and invertebrate cells. Flaviviruses use several specialized proteins to first make an uncapped negative strand copy of the viral genome that is used as a template for the synthesis of large numbers of capped genomic RNAs. Despite using relatively simple mechanisms to replicate their RNA genomes, there are significant gaps in our understanding of how flaviviruses switch between negative and positive strand RNA synthesis and how RNA capping is regulated. Recent work has begun to provide a conceptual framework for flavivirus RNA replication and capping and shown some surprising roles for genomic RNA during replication and pathogenesis. WIREs RNA 2013, 4:723–735. doi: 10.1002/wrna.1191
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Conflict of interest: The authors have declared no conflicts of interest for this article.

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