This study examined muscle activation and relative joint angles during a conventional deadlift while using either a double‐pronated or overhand/underhand (OU) grip. Ten weight‐trained individuals performed the deadlift with 60% and 80% of their 1‐repetition maximum, with three different grip variations. EMG recordings were taken of the left and right biceps brachii, brachioradialis, upper trapezius, and upper latissimus dorsi. Motion capture was used to measure angles of the wrist, elbow, knee, and hip. With an OU grip, significant bilateral asymmetry was seen in EMG activity of biceps brachii and brachioradialis. Mean wrist and elbow angle also showed significant bilateral asymmetry when using an OU grip. Training recommendations for the OU grip deadlift should emphasize the need to vary which hand is supinated/pronated to avoid muscle imbalances and possible injury. Furthermore, it may be preferential to use a double‐pronated grip to avoid asymmetric training altogether.