The effects of Abelmoschus esculentus (okra) and Piper guineense (black pepper) on the histomorphology of the gastric mucosa of the fundic stomach were investigated. Twenty adult wistar male rats weighing (123-207g), divided into four groups 1, II, III &1V, group 1 as control and groups II, III &IV as experimental groups. The rats in the control group were administered with distilled water, while rats in group II and III were administered with 500mg/kg of Abelmoschus esculentus and 20mg/kg of piper guineense respectively. Group IV received a combination of the two extracts. After 28days of administration of extracts, animals were sacrificed stomach was extracted and processed to paraffin section, cut at 5micron, stained, and observed histopathologically under light microscope. Result showed marked significance of the effect of the single extract of Abelmoschus esculentus, Piper guineense and the combination of both extracts, while the histopathology findings revealed glandular erosion, mucosal erosion, inflammation, ulceration, degeneration of mucosal lining cells and epithelium, degeneration of chief and parietal cells and granulated eosinophilic cells as compared to control group 1. Statistical value in the weight of the body and stomach showed significant value (p<0.05) compared to the control. In conclusion, it is observed that the usage of the two extract as single and combine posed a degree of pathological condition on the gastric mucosa.