Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects
Division of Cosmetic Science, Department of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. Skin pharmacology and physiology
(Impact Factor: 2.37).
07/2013; 27(1):9-17. DOI: 10.1159/000351349
Modern men have changed their beauty and grooming habits, which has resulted in an increasing demand for cosmetics for men. However, very little information is available about the dermatological needs of male skin. Therefore, the aim of this present clinical study was to conduct the first systematic assessment of the skin physiology of men with special attention to lifetime changes.
A total of 150 healthy male subjects (aged 20-70 years) were selected following strict criteria, including age, sun behavior and smoking habits. Transepidermal water loss (TEWL), hydration level, sebum production and pH values were measured with worldwide-acknowledged biophysical measuring methods at the forehead, cheek, neck, volar forearm and dorsum of hand.
TEWL and sebum production vary by localization, but generally not with increasing age, whereas stratum corneum (SC) hydration decreases significantly at the face and neck. The greatest decrease was assessed at the forehead. Skin surface pH significantly increases with aging in the face.
The present study assigns for the first time systematic reference values for standardized biophysical measuring methods and localizations reflecting the skin physiology of men in relation to age. The results show that the physiology of male skin partly changes with aging. While SC hydration and skin surface pH are affected by the subject's age, TEWL and sebum production show only minor variations.
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ABSTRACT: Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to more easily penetrate through the skin. However, age-related differences in the lethal potency of VX have yet to be evaluated using the percutaneous (pc) route of exposure. Thus, we estimated the 24 and 48h median lethal dose for pc exposure to VX in male and female rats during puberty and early adulthood. Pubescent, female rats were less susceptible than both their male and adult counterparts to the lethal effects associated with pc exposure to VX possibly because of hormonal changes during that stage of development. This study emphasizes the need to control for both age and sex when evaluating the toxicological effects associated with nerve agent exposure in the rat model.
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ABSTRACT: A series of cases of symmetric acral keratoderma have been recently described in China.However, no studies about its demographic information and epidermal barrier function have been documented.Objective To describe the clinical manifestation,demographic information,and clinicopathologic features of 71 cases with symmetric acral keratoderma.
Seventy-one cases with symmetric acral keratoderma were retrospectively reviewed.Their demographic information, clinical manifestations,histopathology and epidermal barrier function were analyzed.
Among these patients, there were 64 males and 7 females, ranging in age from 4 to 53 years with an average age at onset of 27.01 ± 8.86 years. The clinical manifestation was characterized by brown hyperkeratotie patches over the dorsum of the hands,palms and feet,dorsal digits and wrists,elbows,knees,and ankles.The lesions became dramatically whitish with mild swelling immediately after soaking in water and resolved spontaneously in winter.In patients, a moderate increase of transepidermal water loss(TEWL) from 16.16±6.15 to 9.9±4.21 g/m(2) h(P =0.0054) and a moderate decrease of skin hydration from 65.9±5.06 to 42.58±10.73(P < 0.01) in comparison with the control group were observed. Histopathological examination revealed epidermal hyperkeratosis, acanthosis and papillomatous hyperplasia as well as dermal infiltration with a few lymphocytes.
Symmetric acral keratoderma is characterized by symmetry,acra,keratinization and mark seasonal changes.The epidermal barrier function of the skin was negatively affected. This article is protected by copyright. All rights reserved.
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