The objective of this study is to develop a novel design of electric bike. The authors used some engineering approach packages in this study to analyze kinetic and dynamics of the system. The newly developed suspension design of the E-bike will also be incorporated using ADAMS and BikeSim simulation into the design consideration of suspension. To improve the ride comfort and driving safety of the E-bike, an optimization problem is formulated based on the comfort and safety cost function. To obtain the optimal performance for the proposed suspension, evolution algorithms (EAs) are studied to obtain the optimal suspension parameters. Because of the unavoidable depletion in the fossil fuel resources and the impending greenhouse effect on the global warming on earth, the use of green energy, such as electric energy, as the power source on transportation vehicle has become ever important. In Taiwan, the demand of using light- weight commuting vehicles in the urban area to reduce the air pollution and the traffic is more prominent. The goal of this study is to obtain optimal suspension parameters for a novel two-wheeler electric bike (E-bike). The computer-aided design engineering using Solidworks packages is adopted to design novel suspensions of the E-bike in this study. In addition, the full bike model established using Adams is used to analyze both the performance of kinematics and dynamics of the E-bike. The hub motors are the newly and popular driving devices for the E-bikes recently. Because the ratio between the sprung and un-sprung masses for hob motors' driving is different from the conventional motorcycle, a great attention on the vibration suppression of the E-bike has been significantly increasing. Vehicle suspensions carry the vehicle bodies and transmit forces between bodies and road; besides, they are responsible for driving safety and ride comfort. For driving safety, a permanent contract between the tires and the road should be assured to avoid the wheel's bouncing conditions. For ride comfort, the suspension is used to filter the undesired vibrations and shocks which are transmitted from the road. The suspension systems basically consist of the spring, the shock absorber and the mechanism. The spring is to carry the mass and to isolate the body from road disturbances; therefore it contributes to the ride comfort mainly. The damper is used to dissipate the undesired energy and to avoid the wheel oscillations so that it contributes to both driving safety and ride comfort. Moreover, driving safety and ride comfort usually conflict with each other, so trade-off between the driving safety and ride comfort is necessary. Therefore, it is difficult to select the damping coefficients manually. Owing to this difficulty, there was a feasible method to tune of race car suspensions via the seven post rig. It has been used to optimize the response of the car by tuning of the dampers. (1) However, they did not discuss the interaction between driving