The theoretical and empirical basis of the study is that there is a strong relationship between economic growth and technological progress. The innovation gap between the European Union and its two main competitors, the US and Japan, has grown despite the increased spending on Research and Development. The international comparisons related to Science and Technology Policy permanently emphasize that in Europe there is much room for improvement in order to eliminate the differences and the inappropriate achievements which are reflected in the economic growth too. The purpose of the study is to answer why Germany lags behind in term of economic growth despite its innovation-leader role and in what extent regional differences appear in the country's innovation performance. The long term general priority of Germany - corresponding to the European Union - is that economic growth and development have to be facilitated in every region. In order to eliminate regional disparities it is essential to improve competitiveness, employment, education and to boost R&D activities. It can be easily observed that the financial support of education and R&D beyond stimulating economic growth can be an opportunity for the alleviation of regional disparities. It is a puzzling question why convergence between East and West Germany has stopped in spite of the numerous government activities to promote economic growth and innovation.