Article

Úlcera solitaria de recto, ¿inflamación, infección, isquemia o trastorno motor?

December 2003
Gastroenterología y Hepatología 26(6)

DOI:10.1157/13048891

Authors:

Adolfo del Val Antoñana

Hospital Universitari i Politècnic la Fe

Eduardo Moreno-Osset

Hospital la Magdalena

["The three-lies disease": solitary rectal ulcer syndrome]

Article

Full-text available

Dec 2007
REV ESP ENFERM DIG

Solitary rectal ulcer syndrome is an uncommon benign condition characterized by rectal bleeding, passage of mucus, and pain. Histological features are well established as obliteration of the lamina propria by fibrosis and smooth-muscle fibers extending from a thickened muscularis mucosa to the lumen. Diagnosis can usually be made on sigmoidoscopy, and biopsies should always be taken. Ulceration is not universally present, and polypoid, non-ulcerated lesions and erythematous areas are also seen. The lesion or lesions are most often found on the anterior or anterolateral wall of the rectum, although they can also be located in the left colon and be more extensive or even circumferential. Lesions are multiple in 30 percent of cases. These are the reasons why this entity is also known as "the disease of three lies". We report a case of solitary rectal ulcer syndrome presenting at endoscopy with an erythematous area on the left side wall of the rectum.

E-mail: evavallejo@etp.com.py Perú LITERATURA

Médica E I R L Eutropio
Nieve

E-mail: evavallejo@etp.com.py Perú LITERATURA MÉDICA E.I.R.L. (EUTROPIO OSCCO NIEVE)

E-mail: gherrera@libun

1039

Librería San
Jr
Camana

E-mail: gherrera@libun.edu.pe LIBRERÍA SAN CRISTÓBAL Jr. Camana, 1039

Edificio Boulevard, mezzanina Local B2, frente al Central

Avenida Principal De La Urbina

Avenida Principal de la Urbina, Edificio Boulevard, mezzanina Local B2, frente al Central. Madeirense, Urbanización La Urbina, Z.P. 1070 Caracas, D.C.

Article

Mecanismos inflamatorios y fibróticos en la enfermedad renal. Protagonistas y terapéutica

December 2017 · Revista del Laboratorio Clínico

Resumen La enfermedad renal es un problema de salud pública por su incidencia, prevalencia y morbimortalidad. La inflamación y fibrosis son el motor de toda alteración del daño renal, independientemente de su origen. El proceso inflamatorio y fibrótico se caracteriza por infiltración de células inflamatorias, liberación de citoquinas, activación de fibroblastos, de señales químicas y vías de ... [Show full abstract] señalización. Este proceso conlleva la generación de células efectoras productoras de matriz extracelular o de complejos de ataque que desemboca en el daño orgánico. Ninguna terapia ha demostrado eficacia total frente al daño inflamatorio o fibrótico. Muchos fármacos, en desarrollo experimental, ejercen su inmunomodulación a través de la regulación de la actividad de muchos tipos de células inmunes y presentan un perfil antiinflamatorio y fibrótico. El objetivo es ser conocedores de la importancia de los procesos que son capaces de provocar el proceso inflamatorio y fibrótico dado que podría tratarse de marcadores diagnósticos y dianas terapéuticas.

Article

Focal persistent inflammation of atopic myelitis: a radiological demonstration

February 2015 · Acta neurologica Belgica

IntroductionAfter its nosological proposal by Kira, many cases with atopic myelitis (AM) have been described in the medical literature with most cases stemming from East Asia. AM has rarely been described in people of Caucasian descent [1-8]. It can be clinically diagnosed when a myelitis occurs in a patient with allergen-specific IgE-positivity fulfilling at least two of the following supporting ... [Show full abstract] criteria: present and/or past history of atopic disease, serum hyperIgEemia (≥240 U/ml), increased CSF level of interleukin-9 (≥14.0 pg/ml) or CCL11/eotaxin (≥2.2 pg/ml), and absence of oligoclonal band (OCB) in the CSF [9]. It usually presents as an acute or subacute, sensory predominant myelopathy which has in contrast to other causes of acute myelopathy often a protracted and sometimes chronic clinical course. Varying degrees of autonomic dysfunction can also be seen [1, 3, 4, 9, 10]. As a rule, motor involvement is so minimal that almost all patients with AM are ambulatory even at the nadi ...

Article

Antioxidant and neuroprotective properties of blueberry polyphenols: A critical review

May 2011 · Nutritional Neuroscience

Objective: The aim of this work was to highlight the effects and the possible mechanisms of the action of blueberry polyphenols on the central nervous system (CNS). Methods: An analysis was carried out, in a temporal order, of the most important literature about this topic and the results have been correlated with the beneficial and protective effects, mainly concerning the CNS. Discussion: ... [Show full abstract] Over the last 10 years an increasing scientific interest has developed about polyphenols, which are very abundant in blueberries, as they have been seen to produce favourable effects related to neuroprotection and linked to a possible decrease of age-related cognitive and motor decline, as shown by the improvement of such functions in animal models with a supplemented diet. Such effects could not only be explained through a purely antioxidant action but also through more complex mechanisms related to inflammation, genic expression, and regulation of cell survival. Conclusions: Despite the wealth of data from animal studies, there is a relative lack of data concerning human beings, even if some positive results are beginning to emerge. Therefore, blueberry polyphenols could become useful pharmacological agents for various conditions including neurological diseases, but further studies are still necessary to attain this objective.