This study was conducted to evaluate the weight reduction effect of yeast hydrolysate-SR101. Thirty female college students participated in a 6 week weight control program. All subjects were randomly assigned to either the placebo group, YH-SR101 (yeast hydrolysate-SR101) group, or eX diet (product of yeast hydrolysate-SR101) group. The mean energy intake of the placebo group was 1445.2364.0 kcal (carbohydrate: 60.1%, protein: 25.6%, fat: 14.3%), while those of the YH-SR101 and the eX diet group were 1505.6296.2 kcal (carbohydrate: 60.5%, protein: 22.2%, fat: 14.8%) and 1353.8326.3 kcal (carbohydrate: 63.2%, protein: 20.9%, fat: 15.9%), respectively. The placebo group lost 0.191.14 kg of body weight, while the treatment groups (YH-SR101 and eX diet) lost 1.130.83 and 1.540.74 kg of body weight, respectively. There were significant differences in the decrease in body weight between the placebo and the treatment group (p