Cystic hydatid disease of the gallbladder

Department of General Surgery, İstanbul University Cerrahpaşa Medical Faculty, İstanbul, Turkey.
The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology (Impact Factor: 0.78). 12/2012; 23(6):825-6. DOI: 10.4318/tjg.2012.0440
Source: PubMed


A 48-year-old male was admitted to our hospital complaining of abdominal pain and jaundice. His body temperature was 36.7 °C, blood pressure 120/70 mmHg and heart rate 76/min. His physical examination revealed mild tenderness in the upper right quadrant of the abdomen and visible jaundice. He had peptic ulcer disease and had been placed on oral antacid treatment. His liver function tests revealed: aspartate aminotransferase (AST): 108 IU/L, alanine aminotransferase (ALT): 186 IU/L, alkaline phosphatase (ALP): 220 IU/L, total bilirubin: 7.1 mg/dl, direct bilirubin: 5 mg/dl, and white blood cell count 13,000 /mm 3 . Gallbladder distension and dilated choledochus were seen in ultrasonography. Additionally, there was a cystic, 3 cm lesion in segment 4b that was interpreted as an inactive hydatid disease. His serology was positive for Echinococcus granulosusand tumor markers were negative. He denied any E. granulosusdiagnosis or treatment in his previous medical history. Computed tomography revealed that he had an inactive calcified hydatid cyst in liver segment 4b and choledocholithiasis, and one of the bile stones was noted to be in the neck of the gallbladder. A significant obstruction in the distal choledochus was shown in the magnetic resonance cholangiopancreatography (MRCP) (Figure 1). In the endoscopic retrograde cholangiopancpancreatography (ERCP), sludge and millimetric bile stones were extracted from the duodenal papilla after sphincterotomy, and the procedure was ended with plastic biliary stenting. His bilirubin levels normalized after ERCP under parenteral antibiotherapy. He underwent laparoscopic cholecystectomy. The calcified lesion was compatible with inactive hydatid cyst. The cholecystectomy was finished uneventfully. Before sending the specimen to the pathology laboratory, we cut the wall of the gallbladder and saw the hydatid cysts (Figure 2). The patient was discharged on postoperative day one and placed on 400 mg/day albendazole treatment. Chronic inflammation and hydatid cyst membranes were observed in the histopathological evaluation of the gallbladder. E. granulosusis responsible for hydatid disease, most commonly in the liver. This infection is usually seen in sheep- and cattle-raising regions. Cholangitis with obstructive jaundice is a rare and dreadful complication of hydatid cysts ruptured into the biliary tract. In addition to the diagnostic capabilities of ERCP, it is a treatment tool for obstructive pathologies of the bile duct (1,2). ERCP shows a cystobiliary relationship, and we did not observe any communication between the gallbladder and the calcified cystic lesion in the liver (3). A false- positive result of the serologic analysis should be kept in mind in patients with previous hydatid disease and no evidence of the disease currently (4). In this case, choledocholithiasis had been concluded as a main cause of the obstructive jaundice after ERCP preoperatively. In such patients, laparoscopic cholecystectomy is the best treatment strategy for preventing further cholangitis attacks. After surgery, macroscopic and pathologic findings revealed a cyst hydatid disease of the gallbladder in the patient, which is a very rare clinical entity (5). ERCP is used to diagnose and treat biliary pathologies. Removal of the gallbladder reduces further risks causing obstructive jaundice and helps in the definitive diagnosis.

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    ABSTRACT: The aim of the study was a retrospective evaluation of 299 cases that were histopathologically diagnosed as cystic echinococcosis (CE) in the pathology laboratory of our hospital in a seven years period. All specimens sent to the laboratory were examined microscopically following macroscopic and hematoxylin eosin (H-E) staining. 299 cases were reviewed according to age, gender and organ affected by the cyst, more than one specimen of the same organ was evaluated once. Of the 299 cases, 44.5% (133) were male whereas 55.5% (166) of them were female. Additionally, %5 (15) of the cases were between 0-15 ages, %31.8 (95) of them were between 16-30 ages, %29.4 (88) of them were between 31-45 ages, % 24.4 (73) of them were between 46-60 ages and %9.4 (28) of them were older than 61. Cysts were mostly localized in liver, lungs and peritoneal cavity, %71.9 (215), %11.4 (34) and %4.7 (14) respectively. Demographic features of our cases were mostly in line with the previous literature. Because of the presence of atypical localized cases, during pathologic evaluation of all surgical cystic specimens, elements of this parasite should be searched and evaluated carefully.
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