This paper provides the rationale for a systematic study of regional patterns of communication in the United States (US). Regionalism is conceptualized, regional influences on communication are examined, and their significance is established. Next, the regional development of the US is described through an account of regional history and an examination of forces that cause the decay, maintenance, and reestablishment of distinct regions. Finally, a program of regional research on US communication is proposed. Deficiencies in prior research are examined, rudimentary research efforts are considered, boundaries are described, and future research directions are provided.