Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men

University of Copenhagen.
AJP Regulatory Integrative and Comparative Physiology (Impact Factor: 3.11). 07/2013; 305(5). DOI: 10.1152/ajpregu.00575.2012
Source: PubMed


Obese individuals are characterized by low circulating adiponectin concentrations and an increased number of macrophages in adipose tissue, which is believed to be causally associated with chronic low-grade inflammation and insulin resistance. Regular physical exercise decreases overall morbidity in obese subjects which may be due to modulations of inflammatory pathways. In this randomized clinical trial we investigated the separate effects of endurance training-induced weight loss, diet-induced weight loss and endurance training per se (without weight loss) on plasma adiponectin multimer composition (Western blotting) and adipose tissue macrophage content (immunohistochemistry) in young, moderately overweight men. Weight loss and endurance training per se decreased whole body fat percentage in an additive manner. No intervention-induced changes were observed for plasma total adiponectin. Surprisingly, endurance training, irrespectively of any associated weight loss, shifted the adiponectin multimer distribution towards a lower molecular weight (21% decrease in HMW/LMW, P=0.015) whereas diet-induced weight loss shifted the distribution towards a higher molecular weight (42% increase in HMW/MMW, P<0.001). Furthermore, endurance training per se increased the number of anti-inflammatory CD163(+) macrophages (from 12.7 [2.1] (mean [SE]) to 16.1 [3.1] CD163(+) cells/100 adipocytes, P=0.013), whereas diet-induced weight loss tended to decrease CD68(+) macrophages in subcutaneous abdominal adipose tissue. Thus, regular physical exercise influences systemic and adipose tissue inflammatory pathways differently than diet-induced weight loss in younger, moderately overweight men. Our data suggest that some of the health benefits of a physically active lifestyle may occur through modulations of anti- rather than pro-inflammatory pathways in young, overweight men.

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Available from: Line Quist Bendtsen, Nov 26, 2014
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    • ") , at least in adipose tissue , where an M1 to M2 phenotype shift had been reported in acute models of exercise in rats ( Oliveira et al . , 2013 ) , exercise - trained mice ( Kawanishi et al . , 2010 ) and humans ( Auerbach et al . , 2013 ) . The exact mechanism for an exercise - induced protection is unclear , but may involve myokine secretion from skeletal muscle ( Hojman et al . , 2011 ) , where oncostatin M ( OSM ) appears to be one promising target . How myokines can cross talk with myeloid cells in the tumor microenvironment is currently unknown , but may involve a"
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