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Effects of the proximal home environment on language and behavioral outcomes in children prenatally exposed to cocaine

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Early Child Development and Care
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Abstract

Proximal environmental variables illustrate aspects of the environment that are experienced directly and specifically by the child. The current study examined the associations between three proximal environmental variables: (1) quality of the home environment, (2) regularity of family routines and (3) frequency of parenting daily hassles and cognitive, language and behavioral outcomes in 36‐month‐old children who were prenatally exposed to cocaine and participating in an early intervention program. The quality of the home environment predicted expressive language and internalizing behavior problems, while daily hassles and family routines only predicted internalizing behavior problems. The results suggest that interventions aimed at changing proximal environmental variables may have positive implications for children who are at‐risk for developmental delay.

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Prenatal cocaine exposure is an indicator for adverse developmental outcomes. To prevent developmental disabilities, an early intervention program for children birth to 3 years was developed that included three groups: center-based, home-based, and primary care comparison. The intervention was implemented across 10 years and data were collected on 342 children and families who were primarily urban, poor, and members of traditionally underrepresented groups. At 36 months of age, center and home-based intervention participants had more advanced cognitive and language abilities and fewer behavior problems than the primary care group participants. In addition, center-based participants had more advanced language abilities than home-based participants. The findings indicate that the early intervention impact is sustainable over time and has a positive effect on children at risk due to prenatal cocaine exposure. Copyright 2005 by the Division for Early Childhood, Council for Exceptional Children.
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To the Editor: The meta-analysis by Dr Frank and colleagues1 concluded that cocaine exposure in utero does not affect physical or behavioral development in offspring. As pointed out by the authors, many inconsistent observations have been reported in the clinical literature, and confounding factors, such as polydrug use, further complicate the interpretation of these studies.It was disappointing, however, that the authors did not highlight the results of recent studies in which children have been prospectively followed up. These studies have shown subtle but consistent deficits in cognitive and attentional processes in 6- and 7-year old children,2- 4 effects that may become more prominent as their cognitive and social development continues. Cocaine has potent effects on neurotransmitters with known effects on the development of limbic cortical circuitry.5 Thus, it is not surprising that in utero exposure to cocaine might lead to cognitive and emotional difficulties in older children and even into adulthood—impairments that simply cannot be assessed in younger children nor with crude global measures. Thus, the conclusions drawn by the authors may be premature.
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The purpose of this article was to specify the relation between parenting stress and the early behavioral organization of 2-year-olds. Twenty-seven families provided assessments of parental stress and child behavior problems. In addition, observations of toddler pretend play and autonomy development were conducted. Mothers who reported higher level of stress within areas of life related to parental adjustment (e.g., relationship with spouse, social isolation, health) had toddlers who exhibited more externalizing and total behavior problems. In addition, mothers who reported higher levels of stress in relation to their toddler (e.g., perceptions of reinforcement from child) were more likely to have toddlers who exhibited behavior problems, less pretend play, and less usage of self-assertion during home observations. Finally, fathers who reported higher levels of stress in relation to their toddler also reported more behavioral problems.
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Groups of mother-preterm (N=26) and mother-full-term (N=34) infant pairs were followed longitudinally from 1 to 24 months corrected age. Measures of maternal attitudes, psychosocial factors, and family demographics were collected at 1, 8, and 18 months, mother-infant behavioral interactions were observed at 4, 8, 12, and 24 months, and infant developmental assessments were conducted at 4, 12, and 24 months. At 24 months, mothers' perception of their family systems was assessed. Results indicated that groups of mother-preterm and mother-full-term infants did not differ in perception of family style or in behavioral interactions at age 2. Correlations between family style and mother-infant behavior at age 2, however, indicated that family style was related significantly more often to measures of mother preterm interaction than mother-full-term interaction. Early maternal attitudes, psychosocialfactors (e.g., social support), and behavioral interactions were related to family style at age 2 for both groups, although again relationships were more often found in the preterm groups. The results are discussed within a transactional framework, suggesting the differential importance of family functioning to high-risk infant development and parent-child relationships. The results also suggest that certain social con texts are specifically related to the development of the family system in both risk and nonrisk groups.
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This paper describes the conceptual foundation underlying the development of the Family Routines Inventory, a new instrument designed to measure the extent of predictability or routinization in the daily life of a family. The primary impetus for the development of this instrument is a theoretical perspective in which family routines are regarded as behaviors which may protect the health and well-being of family members by providing stability and continuity during periods of stressful change.
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To test the efficacy of temporally patterned kinesthetic and auditory stimulation for promoting development of infants born prior to term, 88 preterm infants, below 35 weeks gestation, were assigned to 1 of 4 experimental or control groups. Control subjects received regular hospital care; fixed interval subjects received 15 min of rocking/heartbeat stimulation each hour; self-activating subjects received 15 min rocking/heartbeat when inactive for 90 sec, but only for 1 stimulation period per hour. Assessments included measures of neurological functioning, sleep-wake activity, mother-infant interaction, and mental and motor development at 8 and 24 months. All experimental infants, compared to controls, showed decreased rates of activity while in the hospital, fewer abnormal reflexes, and better orienting responses. At 24 months, experimental infants scored significantly higher on the Mental Development Index of the Bayley Scales. Few differences were found in parent-infant interaction patterns. The results indicate that both temporal patterning and contingent responsiveness in the preterm infant's early environment contribute positively to some aspects of the development of such infants.
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In 2 earlier investigations, we found that scores on the HOME Inventory administered during the first 2 years of life were substantially correlated with intelligence test scores at ages 3 and 4 1/2. In the current investigation, HOME scores in first 2 years showed similar relations to SRA Achievement Test scores during the first grade. In general, findings from this study were like those from the earlier investigations except that the subscale, "maternal responsivity," showed a weaker relation to achievement than IQ; while the "variety of stimulation" scale showed a stronger relation. Of all the HOME subscales, "play materials" revealed the strongest correlation with first-grade achievement. When 12-month Bayley MDI scores were partialed out of the HOME/achievement relation, little reduction was noted in the magnitude of the correlation; however, when 3-year IQ or subsequent HOME scores were partialed out, little residual correlation was noted.
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This report builds upon pertinent theoretical considerations regarding the nature and importance of routinization within families and describes the development and validation of a standardized inventory to measure family routines. The Family Routines Inventory (FRI) measures 28 positive, strength-promoting family routines, those observable, repetitive behaviours which involve two or more family members and which occur with predictable regularity in the daily life of a family. The 28 routines were selected from an extensive list of 104 routines obtained through family interviews. Scoring options for the inventory were identified based on their face validity and consistency with the underlying theoretical construct. The inventory was subsequently administered to a diverse group of families for reliability and validity testing. This testing identified an optimal scoring method (frequency score) for the inventory and revealed that the Family Routines Inventory, which measures the extent and importance of routinization within a given family, appears to be a reliable and valid measure of family cohesion, solidarity, order and overall satisfaction with family life.
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This study investigated whether disruption of family-of-origin rituals and routines would mediate the relationship between family history of parental problem drinking (FH+, FH-) and two outcomes in adult offspring: adult children of alcoholics (ACOA) personality attributes and drinking problems. The self-reports of 143 students and 129 outpatients indicated that disruption of family routines and rituals mediated the relationship between family history status and both ACOA traits and problem drinking. These results suggest that the mediating effect of family-of-origin rituals and daily routines may explain some of the heterogeneity in adult outcomes of offspring from FH+ families, in both student and clinical samples.
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To identify perinatal factors that are predictive of disruption in primary caregiving among infants of substance abusing women. A randomized longitudinal cohort study. One hundred and fifty two mother/infant dyads were assessed for evidence of disruption of primary caregiving or neglect during the first 18 months of life, defined by mother's inability to provide care. Data analyzed included neonatal characteristics, urine toxicology at delivery, maternal history of drug use, maternal depression, social support, and social and health history. Sixty-six infants (43.4%) had disruption in their primary care during the first 18 months of their life, 86 infants (56.6%) remained in the care of their mothers. Women who were younger, were heroin users, had two or more children, had other children in foster care, and reported depressive symptoms were least likely to provide ongoing primary care for their infant. Although all infants born to substance abusing women are at a high risk for disruption in the continuity of their primary caregiving, maternal demographic and psychosocial factors present at delivery can predict which infants are likely to experience an early disruption in their primary caregiving. Identifying these families can enable health care providers to monitor them more closely and, when appropriate, encourage support from the extended family.
Article
Children with in utero cocaine exposure may be at risk for adverse neurodevelopmental outcome. To evaluate such outcome in young children, we administered the Battelle Developmental Inventory (BDI) to a group of inner-city children with (COC) and without (CON) in utero cocaine exposure at ages 3 and 5 years. Sixty-five COC and 68 CON, similar at age of testing, were evaluated at both time points by examiners masked to child group status. Both groups scored poorly and worsened over time. Although Total BDI raw scores were lower in the COC group than in the CON group at 3 years, this difference was related to postnatal environmental factors, caregiver (p = .022), and home environment (p = .010), not to in utero cocaine exposure (p = .88). At 5 years, the Total BDI score was related to the home environment (p < .001) but not to the caregiver (p = .36) or in utero cocaine exposure (p = .83). We conclude that inner-city children are at risk for adverse developmental outcome regardless of in utero cocaine exposure.
Article
Alcohol and other drug use during pregnancy represents a major public health concern. This article characterizes a sample of 240 pregnant opioid- or cocaine-dependent women enrolled in the initial residential component of a comprehensive substance abuse treatment program for pregnant women. Data were collected using the Addiction Severity Index, Psychosocial History Form, and Structured Clinical Interview for DSM-III-R. Patients' substance use history, psychiatric comorbidity, social support network, employability, current and previous pregnancies, child custody arrangements, and the father of the current pregnancy, are described to assist providers in tailoring treatment to the specific needs of this population.
Article
This prospective study examined the effects of ongoing maternal drug use, parenting attitudes, and a home-based intervention on mother-child interaction among drug-using women and their children. At 2 weeks postpartum, mothers and infants were randomly assigned to either an Intervention (n = 67) or Control (n = 64) Group. Intervention families received weekly visits until 6 months postpartum and biweekly visits from 6 to 18 months by trained lay visitors. The home intervention was designed to increase maternal empowerment and promote child development. Control families received brief monthly tracking visits. Mother-child interaction was evaluated at 18 months through observation of play. Mothers who continued to use cocaine and/or heroin had lower competence scores (p <.05); poor parenting attitude was also associated with lower competence scores during mother-child interaction (p <.05). Although the intervention had no measured effect, ongoing maternal drug use and poor parenting attitudes were associated with less optimal maternal behavior during mother-child interaction.
Article
To assess teratogenic effects of cocaine exposure and maternal psychological distress on birth outcomes, we conducted a longitudinal prospective study of 415 infants (218 cocaine-exposed--CE, 197 nonexposed--NE). Drug exposure was determined through a combination of maternal self-report, urine, and meconium screens. Maternal psychological distress postpartum was evaluated through a standardized, normative, self-report assessment. An extensive set of confounding variables was controlled, including severity of exposure to alcohol, tobacco, marijuana and other drugs, maternal age, race, parity, number of prenatal care visits, educational, marital, and socioeconomic status, and verbal and nonverbal intelligence. CE infants were smaller on all birth parameters and more likely to be preterm, small for gestational age, and microcephalic than NE infants. Forty-one percent of cocaine users had clinically significant psychological symptoms, compared to 20% of a high-risk comparison group of noncocaine users. Consistent with a teratologic model, cocaine exposure independently predicted offspring birthweight, length, and head circumference. Maternal psychological distress self-reported postnatally also independently predicted head circumference. Tobacco, alcohol, and marijuana exposures were also significant independent predictors of some fetal growth parameters. In addition, maternal distress symptoms, which may be reflective of maternal mental health disorders or responses to stress, added significantly to the risk for poorer fetal growth.
Article
A considerable body of research suggests that children who are prenatally exposed to alcohol and other drugs are also at risk for receiving poor quality parental care. Previous research in human behavioral teratology has focused on postnatal environment as a potential confounding factor. Yet, developmental theory suggests that development proceeds as a series of transactions between children's characteristics and their environments. In order that possible teratologic effects not be underestimated, future work needs to give more consideration to ways in which parental care may be influenced by child behavior and to ways in which postnatal environment might moderate the expression of teratologic effects. Studies must focus on the role of prenatal drug exposure within a broader system of variables that includes factors present in children's environments over time.
Article
The present study estimates the longitudinal effects of in utero cocaine exposure on language functioning at 3, 5 and 7 years of age in an urban sample of 443 full-term children (236 cocaine-exposed and 207 noncocaine-exposed) participating in the Miami Prenatal Cocaine Study. The sample was enrolled prospectively at birth, with documentation of prenatal drug exposure status through maternal interview and urine and meconium toxicology assays. Language functioning was measured at ages 3 and 5 years using the Clinical Evaluation of Language Fundamentals-Preschool (CELF-P) and at age 7 years using the Core Language Domain of the NEPSY: A Developmental Neuropsychological Assessment. Longitudinal Generalized Linear Model and Generalized Estimating Equations (GLM/GEE) analyses revealed an association between prenatal cocaine exposure and deficits in total language functioning after statistically controlling for child sex, visit age, prenatal exposure to alcohol, marijuana and tobacco and over 20 additional medical and sociodemographic covariates drawn from potentially confounding influences assessed at birth and follow-up visits (D=-0.17; 95% CI=-0.32, -0.03; P=.019). The link from prenatal cocaine exposure to later language deficits does not appear to be mediated by cocaine-associated deficits in birth weight, length or head circumference. Overall, the evidence tends to support an inference of a stable cocaine-specific effect on indicators of language functioning during early childhood through age 7 years.
Article
The theoretical framework for many of the early studies of prenatal cocaine exposure has been rooted in the basic concepts of teratology/developmental toxicology. Few have published longitudinal analyses of the complex interplay between the relative effects of prenatal cocaine exposure and perinatal and environmental factors on development. The purpose of this paper was to use structural equation modeling to describe the direct and indirect effects of prenatal drug exposure on developmental outcome from birth to age 6 months. Key variables considered for study include prenatal drug exposure, perinatal medical characteristics, maternal/caregiver/family characteristics, the home environment, and neurobehavioral outcomes. We prospectively enrolled 154 predominantly crack-using women. A priori exclusion criteria included: <18 years old, major illnesses diagnosed prior to pregnancy, chronic use of legal drugs, and any use of illicit drugs other than cocaine and marijuana. From the pool of noncocaine users, 154 subjects were matched to users on pregnancy risk, parity, race, and socioeconomic status. At the end of each trimester, experienced staff conducted private interviews prompting memory of amount and timing of past drug use. Urine specimens were collected at two unanticipated times; positive screens were confirmed by gas chromatography/mass spectroscopy. Measures analyzed include medical (birth) and developmental (birth, 1 month, 6 months) assessments, all performed by blinded evaluators, as well as caregiver characteristics and environmental factors (birth, 1 month). A series of four theoretical models was tested, one for each time point (birth, 1 month, 6 months) and a longitudinal model spanning birth to 6 months. Key findings include direct effects of prenatal cocaine exposure on development at birth in the birth model and on development at birth and 6 months in the longitudinal model. In addition, indirect effects of prenatal cocaine exposure were identified on development at birth, 1 month, and 6 months, mediated through the prenatal use of alcohol and tobacco and the birth head circumference. Implications of these and other findings, including the advantages and limitations of structural equation modeling, are discussed.
Article
A variety of family processes have been hypothesized to mediate associations between income and young children's development. Maternal emotional distress, parental authoritative and authoritarian behavior (videotaped mother-child interactions), and provision of cognitively stimulating activities (Home Observation for Measurement of the Environment [HOME] scales) were examined as possible mediators in a sample of 493 White and African American low-birth-weight premature infants who were followed from birth through age 5. Cognitive ability was assessed by standardized test, and child behavior problems by maternal report, when the children were 3 and 5 years of age. As expected, family income was associated with child outcomes. The provision of stimulating experiences in the home mediated the relation between family income and both children's outcomes; maternal emotional distress and parenting practices mediated the relation between income and children's behavior problems.
Article
The current study is a population-based investigation of birth risk factors for school-identified specific language impairment (SLI). The sample consisted of 244,619 students (5,862 SLI) born in Florida between 1989 and 1990 who were in the Florida public school system at ages 6-7. Epidemiological measures of effect were used to investigate both individual- and population-level risk for SLI. Very low birth weight (VLBW), low 5-min Apgar score, late or no prenatal care, high birth order, and low maternal education were associated with highest individual-level risk. Low maternal education and having an unmarried mother was associated with the highest population-level risk. The results not only suggest who needs to be screened for a future developmental disability, but identify a group of children who are at-risk for an SLI placement in school. Early intervention services for these children may be the most effective approach to reducing the incidence of school-identified SLI.
Article
Context: Because of methodological limitations, the results of the few prospective studies assessing long-term cognitive effects of prenatal cocaine exposure are inconsistent. Objective: To assess effects of prenatal cocaine exposure and quality of caregiving environment on 4-year cognitive outcomes. Design: Longitudinal, prospective, masked comparison cohort study from birth (September 1994-June 1996) to 4 years. Setting: Research laboratory of a US urban county teaching hospital. Participants: A total of 415 consecutively enrolled infants identified from a high-risk population screened for drug use through clinical interview, urine, and meconium screens. Ninety-three percent retention for surviving participants at 4 years of age resulted in 376 children (190 cocaine-exposed and 186 nonexposed). Main outcome measure: The Wechsler Preschool and Primary Scales of Intelligence-Revised. Results: After control for covariates, prenatal cocaine exposure was not related to lower full-scale IQ (cocaine exposed [80.7] vs nonexposed [82.9]; P =.09) scores or summary verbal (cocaine exposed [79.9] vs nonexposed [81.9]; P =.11) or performance (cocaine exposed [85.5] vs nonexposed [87.5]; P =.18) IQ scores at age 4 years. However, prenatal cocaine exposure was related to small but significant deficits on several subscales (mean [SE]): visual-spatial skills (cocaine exposed [7.3 (0.22)] vs nonexposed [8.2 (0.22)]; P =.01), general knowledge (cocaine exposed [6.1 (0.18)] vs nonexposed [6.7 (0.17)]; P =.04), and arithmetic skills (cocaine exposed [6.2 (0.20)] vs nonexposed [6.8 (0.20)]; P =.05). Prenatal cocaine exposure was also associated with a lower likelihood of achievement of IQ above normative means (odds ratio, 0.26 [95% confidence interval, 0.10-0.65]; P =.004). The quality of the caregiving environment was the strongest independent predictor of outcomes. Cocaine-exposed children placed in nonrelative foster or adoptive care lived in homes with more stimulating environments and had caregivers with better vocabulary scores, and they attained full-scale and performance IQ scores (83 and 87, respectively) similar to nonexposed children in biological maternal or relative care (full-scale IQ, 82; performance IQ, 88) and higher than cocaine-exposed children in biological maternal or relative care (full-scale IQ, 79; performance IQ, 84). Conclusions: Prenatal cocaine exposure was not associated with lower full-scale, verbal, or performance IQ scores but was associated with an increased risk for specific cognitive impairments and lower likelihood of IQ above the normative mean at 4 years. A better home environment was associated with IQ scores for cocaine-exposed children that are similar to scores in nonexposed children.
Article
This study utilized data from representative probability samples of five social service and health care populations and the general population to assess the prevalence of parent and family-related problems that are known to place children at risk for mental and developmental disorder. Risk factors were analyzed according to a theoretical conceptual framework. Chi-square analysis was used to determine how subsamples of the five clinical populations differed from a subsample of the general population on a set of eight risk factors. Results indicated that compared to the general population, the percentage of respondents with family-related risk factors was significantly higher across the five clinical subsamples. Findings suggest that a fruitful way to identify and intervene with children at risk for mental and developmental disorder may be in conjunction with services that treat their parents. Joint parent-child interventions that aim at prevention as well as treatment can be designed.