Article

Depletion of Omega3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

University Department of Psychiatry, Sheffield, United Kingdom.
Biological Psychiatry (Impact Factor: 10.26). 03/1998; 43(5):315-319. DOI: 10.1016/S0006-3223(97)00206-0

ABSTRACT

Background:
It has been hypothesized that depletion of cell membrane n3 polyunsaturated fatty acids (PUFA), particularly docosahexanoic acid (DHA), may be of etiological importance in depression.

Methods:
We measured the fatty acid composition of phospholipid in cell membranes from red blood cells (RBC) of 15 depressive patients and 15 healthy control subjects.

Results:
Depressive patients showed significant depletions of total n3 PUFA and particularly DHA. Incubation of RBC from control subjects with hydrogen peroxide abolished all significant differences between patients and controls.

Conclusions:
These findings suggest that RBC membranes in depressive patients show evidence of oxidative damage. Possible interpretations, and implications for the etiology and treatment of depression, are discussed.

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Available from: Brendan P Murphy, Jan 14, 2016
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    • "We also demonstrated that CORT treatment increased the n-6:n-3 fatty acid ratio. A higher n-6:n-3 ratio has been previously associated with the development of stress-related pathologies (Maes et al., 1996;Peet et al., 1998). Interestingly, our study showed differential CORT effects on the cellular composition of the rat mixed cortical primary culture. "

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    • "Interestingly, elevated dietary consumption of trans-fatty acids, such as that implemented in studies described above, has been shown to reduce brain docosahexaenoic acid, an omega-3 PUFA with described antidepressant actions (Phivilay et al., 2009). Indeed, insufficient dietary PUFA augments depression risk (Peet et al., 1998), whereas increasing dietary omega-3 PUFA has been shown to be protective (Lin & Su, 2007;Moranis et al., 2012;Oddy et al., 2011) and to prevent inflammation-induced depression (Su et al., 2014). Diets rich in saturated fatty acids are associated with increases in overall adiposity and bias visceral fat accumulation (Rosqvist et al., 2014). "
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    • "Such increased O&NS contributes to omega-3 fatty acid depletion in depressed patients [39], an increased serum oxidant/anti-oxidant ratio [40], decreased antioxidant system functioning, as indicated by lower levels of plasma vitamin E [41] [42] and vitamin C concentrations [25], as well as reduction in wider antioxidants including zinc, glutathione (GSH) and CoQ10 [15]. Concurrently lower levels of antioxidant-enzymes can occur in depression, including superoxide dismutase (SOD) and glutathione peroxidase (GpX) [18]. "

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