Bases moléculaires de la pathogénicité des Salmonella
In order to establish a successful infection, Salmonella must colonize host membranes, adhere to and invade epithelial cells, survive and even multiply in the reticuloendothelial system, produce tissue damages, and resist to host defence. Salmonella expresses virulence factors to fulfill these requirements. In S. typhi, the agent of human typhoid fever, all these factors are encoded by chromosomal genes. In S. typhimurium, the agent of murine typhoid fever, virulence factors are encoded by both chromosomal and plasmid genes. These factors, their functions and the genes involved in their synthesis and expression are covered in this review.