Article

Bacteriemie a Flavobacterium odoratum

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Abstract

A case of bacteremia due to Flavobacterium odoratum is reported. It occured in a patient with acute cardiac failure, diabetes, arteritis. Bacteriological diagnosis of the genus Flavobacterium is described. Hypothesis on the origin of this bacteria are raised.

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... Based on a review of the cases of bacteremia caused by Myroides spp. listed in the U.S. National Institutes of Health's National Library of Medicine (Pubmed), it is noteworthy that bacteremia most commonly develop secondary to soft tissue or catheter related infections [1,3,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] (Table 3). This case is the 7 th catheter related bacteremia reported. ...
... Although isolated Myroides spp. are generally susceptible to fluoroquinolones, piperacillin/tazobactam, trimethoprim/ sulfamethoxazole carbapenems and tetracyclines [12,16,17,20,[25][26][27][28][29] recently pan-resistant species and presence of metalloenzymes have been reported [30,31]. Ming et al., in their analysis of pan-resistant M. odoratimimus identified resistance genes to tetracyclines (tetX), macrolides (ereB), lincosamide (lasE), sulfonamides (sul2, sul3), beta-lactams (bla MUS-1 , bla TUS-1 , bla SFB-1 , bla SLB-1 , bla OXA-209 , bla OXA-347 ), chloramphenicol (cat) and fluoroquinolones (parE) and 18 antibiotic efflux pump-encoding genes [30]. ...
Article
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Myroides spp. are opportunistic environmental Gram-negative bacteria. These affect mostly immunocompromised hosts and generally lead to soft tissue, and urinary tract infections. Bacteremia most commonly develop secondary to soft tissue or catheter related infections and may lead rarely to mortality. Myroides spp. are generally suscetible to fluoroquinolones, piperacillin/tazobactam, trimethoprim/sulfamethoxazole, carbapenems or tetracyclines however, pan-resistant isolates and multiple resistance genes have been reported in clinical isolates of Myroides spp. We report a pan-resistant Myroides odoratimimus bacteremia in a patient with severe COVID-19 ending with fatality and in this context a review of reported Myroides bacteremias are also described. In this study, a 64-year old male patient with history of coronary artery bypass was admitted to ICU with severe COVID-19 pneumonia accompanied by pneumomediastinum and pneumopericardium. Continous renal replacement therapy and extracorporeal membraneous-oxygenation were initiated due to acute renal failure and persistent hypercarbia/hypoxia, respectively. Within four weeks of hospitalization various episodes of bacteremia developed and multiple antibiotics were used. On the 5 th week of follow-up, acute phase reactants increased and empirical broad spectrum antibiotics were initiated. Blood culture revealed Gram-negative rods. The patient became hypotensive and despite maximum medical care he was lost due to cardiac arrest. M. odoratimimus was identified by MALDI-TOF and the bacterium was pan-resistant. According to Center for Genomic Epidemiology results the strain was identified as M. odoratimimus PR63039 and the genome analysis revealed antibiotic resistance genes associated with resistance to beta-lactams ( bla OXA-347 , bla MUS-1 , bla EBR-1 ), tetracyclines ( tetX ), sulfonamides ( sul2 ), macrolides ( ereD ), ( ermF ).
... Myroides spp. grow well in high concentrations of glucose, and in our review we found that diabetes was a comorbidity in several cases [6,13,19,20,25,[27][28][29]31]. Cirrhosis may be another risk factor for infection. ...
Article
Myroides spp. are environmental bacterial organisms that rarely cause disease in humans. Myroides spp. infections are infrequently reported in the literature, and Myroides injenensis infections are quite uncommon. Myroides spp. usually infect immunocompromised hosts and can have highly resistant antibiotic susceptibility patterns. Here we report a case of Myroides injenensis bacteremia and severe cellulitis in a patient with cirrhosis and review the literature of other Myroides spp. infections.
... odoratus and odoratimimus) are immunocompromised or have end-stage renal disease, cirrhosis, chronic obstructive pulmonary disease, neoplasms, or heart diseases (4-7, 9, 13-16). While M. odoratus infections in diabetics have been documented, to our knowledge, ours is the fi rst documented case of M. odoratimimus in a diabetic patient (14,16). Of the fi ve documented reports of M. odoratimimus infections, two involved nosocomial outbreaks of urinary tract infections in the setting of urinary stones or cancer (9,17). ...
Article
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Myroides species are a rare source of human infection. Though not part of the human microbiota, Myroides species are commonly found in the environment. Myroides infections are typically attributed to contact with contaminated water; the most common presentation is in immunocompromised patients. We present a patient with a diabetic foot ulcer who subsequently developed Myroides odoratimimus bacteremia and bone abscess.
... Myroides strains usually behave as low-grade opportunistic pathogens, and have been found to be responsible for cases of urinary tract infection [7,8], endocarditis [9], and ventriculitis [10]. Cutaneous infections (surgical wound infections [7,11], cellulitis [12][13][14][15][16], and necrotizing fasciitis [17]) have also been described, often as a complication of septic dissemination. A precise discrimination of the causative species has become possible only in recent years thanks to molecular typing techniques, which have made it possible to recognize M. odoratus as the etiologic agent in cases of septic cellulitis [14,15], and M. odoratimimus as responsible for cases of urinary infection [8] and one case of cellulitis associated with bacteremia [16]. ...
Article
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The genus Myroides comprises aerobic, yellow-pigmented, non-motile, non-fermenting gram-negative rods formerly classified as Flavobacterium odoratum. Members of the genus are widely distributed in the environment, especially in water, and usually behave as low-grade opportunistic pathogens, having been found to cause urinary tract infection, endocarditis, ventriculitis, and cutaneous infections in severely immunocompromised patients. We report a case of soft tissue infection, septic shock, and pneumonia due to M. odoratimimus in an immunocompetent male. To our knowledge, this is the first description of life-threatening infection caused by this organism in an immunocompetent host. We have also reviewed the medical literature on the genus Myroides.
Article
The genus Myroides classified as Flavobacterium odoratum comprises non- motile ,aerobic, yellow –pigmented .They are non hemolytic on blood agar while it show a good growth on MacConkey and nutrient agar with salt tolerant up to 5% of NaCl also non fermented gram-negative rods .Members of the genus are cause many infectious disease in severely immunocompromised patient includes endocarditics urinary tract infection ,cuteneous infection ,and ventriculitis that behave as low grade opportunistic pathogens and widely distributed in the environment specially in water. Myroides spp. should be attribute among pathogens in hospitalized ,catheterized patients with wide resistant to antibiotic specially Minocycline is useful treating UTI caused by the genus . 16S ribosomal RNA(rRNA) sequencing can identified accurately the species level .In this reviews which description of dangerous infection duo to by Myroides in an immunocompromise host ,moreover reviewed the antibiotic resistance and pathogenesis. Many species of the genus Myroides were primarily taking from intestine of human. The genus Myroides includes five species : M. odoratus. , M. pelagicus, M. profundi , M. odoratimimus and M. marinus , by susceptibility to desferrioxamine . M. profundi has produced a protease Myroilysin ,with characterized as playing a role in hydrolysis of collagen through collagenase production and elastinolytic activity displaying by metalloprotease and playing important role with collagenase for hydrolysis of collagen that proven virulence of genus.
Article
Full-text available
Myroides species are bacteria found commonly in environmental sources, such as water and soil. Despite this, they are historically uncommon pathogens, tending to affect primarily immunocompromised hosts. Based on a review of the current cases listed in the U.S. National Institutes of Health's National Library of Medicine (Table 1), there have been 48 reported cases of infection to date, one third of which have been reported in only the last seven years. This report outlines a case of bacteremia caused by Myroides species occurring in a diabetic male on chemotherapy for Merkel cell cancer. Myroides species can be difficult to treat, many strains are resistant to several antibacterial classes, this patient was treated successfully with meropenem.
Chapter
The name Flavobacterium was proposed in 1923 for a genus of the family Bacteriaceae, encompassing the rod-shaped, nonendosporeforming, chemoorganotrophic bacteria (Bergey et al., 1923). Most of the pigmented bacteria of the family were segregated in the tribe Chromobactereae, which contained four genera of aerobic bacteria separated from each other by differences in color. These genera were Chromobacterium, Flavobacterium, Pseudomonas, and Serratia, for the purple, yellow, green fluorescent, and red strains, respectively. This emphasis on pigmentation (a character shared by genetically diverse bacteria [Weeks, 1969]) for taxonomic assignment to Flavobacterium has given the genus a dubious reputation in the past (McMeekin et al., 1972; Weeks, 1969), and as a consequence the genus has served too frequently as a repository for pigmented bacteria that possess the general attributes of Flavobacterium but had not been subjected to detailed classification studies. Taxonomic heterogeneity and general uncertainty have characterized Flavobacterium from its inception, and its history is a record of proposals to achieve credibility for the genus.
Article
Strictly aerobic Gram negative bacteria are found more and more often in human pathological specimens and in the environment. Amongst these bacteria, Flavobacterium poses problems of bacteriological diagnosis as their precise taxonomy is still recent. In this study, conducted on 321 strains of Flavobacterium from various sources, but essentially from patients in the intensive care unit, the authors define the methods and features of identification and the clinical significance of the species of the Flavobacterium genus. One species is particularly important in medical bacteriology, Flavobacterium meningosepticum which can cause septicaemia and neonatal meningitis which are difficult to treat.
Isolement, identification, signification clinique des espèces du genre Flavobacterium
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The genus Flavobacterium. Bergey's manual of systematic bacteriology — Vol. 1
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