Consider the following Markov chain, whose states are all domino tilings of a 2n Theta 2n chessboard: starting from some arbitrary tiling, pick a 2 Theta 2 window uniformly at random. If the four squares appearing in this window are covered by two parallel dominoes, rotate the dominoes 90 o in place. Repeat many times. This process is used in practice to generate a random tiling, and is a widely used tool in the study of the combinatorics of tilings and the behavior of dimer systems in statistical physics. Analogous Markov chains are used to randomly generate other structures on various two-dimensional lattices. This paper presents techniques which prove for the first time that, in many interesting cases, a small number of random moves suffice to obtain a uniform distribution. 1 Introduction This paper is concerned with algorithmic problems of the following type: given a simply connected region S of the two-dimensional Cartesian lattice (e.g., an n Theta n chessboard),...