Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial

Department of Paediatrics, Imperial College London, London, United Kingdom.
PLoS ONE (Impact Factor: 3.23). 06/2013; 8(6):e66627. DOI: 10.1371/journal.pone.0066627
Source: PubMed


Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.
We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.
Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years. ISRCTN68645785.

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Available from: John O Warner, Aug 20, 2014
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    • "However, this clinical trial has some limitations such as small size, initiation of vitamin D supplementation in late pregnancy, inadequate dose administration (800IU D2 daily or oral 200.000IU D3 bolus), while authors also acknowledged that it was not initially designed to assess the specific outcomes and was not double blind [154]. In order to overcome some of the limitations of the previous studies, two on-going randomized, controlled double blind trial are in progress, exploring earlier prenatal vitamin D supplementation in relation to its effects on childhood asthma and allergy at 3 years of age ([155] and ABCvitaminD NCT00856947). "
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