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Hemorrhoids are a very common condition. Hospital-based proctoscopy studies show prevalence rates of hemorrhoids in up to 86 percent of patients studied with many in an asymptomatic state. Botanicals used internally and topically can treat early stages of hemorrhoids effectively and can be used as adjuncts in more advanced stages when surgical treatments may be necessary. The roles of butcher's broom (Ruscus aculeatus), horse chestnut (Aesculus hippocastanum), stone root (Collinsonia canadensis), witch hazel (Hammamelis virginiana), arnica (Arnica spp.), oak (Quercus spp.), chamomile (Matricaria recutita), gotu kola (Centella asiatica), calendula (Calendula officinalis), and psyllium (Plantago ovata) in hemorrhoid treatment are discussed.
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Kathy Abascal, B.S., J.D., R.H. (A.H.G.)
and Eric Yarnell, N.D., R.H. (A.H.G.)
Abstract
Hemorrhoids are a very common condition. Hospital-
based proctoscopy studies show prevalence rates of
hemorrhoids in up to 86 percent of patients studied with
many in an asymptomatic state. Botanicals used internally and
topically can treat early stages of hemorrhoids effectively and can
be used as adjuncts in more advanced stages when surgical treat-
ments may be necessary.
The roles of butcher’s broom (Ruscus aculeatus), horse chestnut
(Aesculus hippocastanum), stone root (Collinsonia canadensis), witch
hazel (Hammamelis virginiana), arnica (Arnica spp.), oak (Quercus
spp.), chamomile (Matricaria recutita), gotu kola (Centella asiatica),
calendula (Calendula officinalis), and psyllium (Plantago ovata) in
hemorrhoid treatment are discussed.
Introduction
Hemorrhoids are understudied and most likely undertreated.
It is estimated that about one half of all Americans have some
discomfort from hemorrhoids by the time they are 50 but only a
much smaller percentage (approximately 4 percent) seek medical
treatment for the condition.1Hospital-based proctoscopy studies
show prevalence rates of up to 86 percent with many patients in
an asymptomatic state.2Clinical experience suggests that botani-
cal treatments and lifestyle changes can relieve hemorrhoid
symptoms in the early stages and can provide significant benefit
as adjunct treatment in the later stages of the ailment. Unfortu-
nately, science has barely begun investigating these fairly ancient
treatments.
Hemorrhoidal tissues, cushions of tissue within the anal canal
that contain blood vessels and supporting tissue made up of
muscle and elastic tissue, are present in all individuals.2There
are usually three major hemorrhoidal cushions oriented to the
right posterior, right anterior, and left lateral positions.
There is a rich network of arteries around the anal canal,
providing a ready supply of arterial blood to hemorrhoidal
blood vessels. It is only when these cushions enlarge causing
negative symptoms that “hemorrhoids” in the vernacular
sense are present. Negative symptoms typically include the
passage of bright red blood that can occasionally be severe
and result in anemia.
If the hemorrhoid originates at the top of the anal canal, it is
referred to as an internal hemorrhoid. If it originates at the
lower end of the canal, near the anus, it is referred to as an
external hemorrhoid. Internal hemorrhoids are usually pain-
less (because this area of the body lacks pain receptors) but
they may bleed when they are irritated and, if large enough,
may protrude from the rectum and cause discomfort. Untreat-
ed internal hemorrhoids can lead to prolapse, in which the
distended internal hemorrhoids are pushed outside of the
anus. If the sphincter spasms, the blood supply to the pro-
lapsed hemorrhoid can be cut off, leading to a strangulated
hemorrhoid.
External hemorrhoids occur outside the anal verge. They can
be painful, swollen, and irritated. Itching can result from external
hemorrhoids although, typically, itching is most commonly
caused by skin irritation.
The stages of internal hemorrhoids are shown in Table 1. Obvi-
ously, pain, bleeding, and problems with passing stool can be
caused by conditions other than hemorrhoids. This article pre-
supposes that such conditions have been ruled out before any
treatment for hemorrhoids is undertaken.
The actual cause of hemorrhoids is not known.2Genetic pre-
disposition, straining during bowel movements, obesity, a seden-
tary lifestyle, pressure on the rectal veins caused by poor posture
and/or muscle tone, and pregnancy are believed to be causes.
Hemorrhoids are common in patients with spinal-cord injuries.
Constipation, chronic diarrhea, poor bathroom habits (such as
overzealous cleaning and wiping), postponing bowel move-
ments, and a fiber-poor diet are also considered to be contribut-
ing causes.3Alcoholic cirrhosis or other causes of portal
obstruction can cause severe hemorrhoids.
Internal Botanical Treatments
Botanical treatments for hemorrhoids have been poorly
researched. Butcher’s broom and horse chestnut are two herbs
that have some scientific validation of benefit in hemorrhoids
but have both been better studied in chronic vascular insuffi-
ciency (CVI) where they have more substantial evidence of
benefit.
285
Botanical Treatments
for Hemorrhoids
Butcher’s Broom
Butcher’s broom is a prickly, small berry–producing shrub in the
Liliaceae family. Its Latin name (Ruscus) is believed to come from the
Anglo Saxon word for holly or box because the plant has a pointed
leaf shape similar to holly leaves. The herb’s common name derives
from its use by butchers to clean meat stalls and keep flies away.
The whole plant contains steroidal saponins and ruscinogens—
the compounds deemed to be most active—but only the dried
rhizomes are used medicinally. Butcher’s broom is typically
administered in capsule form, and is frequently paired with
trimethylhesperidin chalcone (a flavonoid complex) and ascorbic
acid.* However, the plant is also available as an alcoholic extract
and a tea. There are also numerous topical preparations often
combining butcher’s broom with sweet clover (Melilotus spp.).
Butcher’s broom has a long history of clinical use as a treat-
ment for hemorrhoids, and its use for treating this condition
has been approved by the German Commission E.4In one
open-label multicenter study of 124 patients, 69 percent of the
patients rated butcher’s broom as having good or excellent
efficacy.5Seventy-five (75) percent of the treating physicians
rated this herb’s efficacy similarly. In addition, 92 percent of
the physicians rated butcher’s broom as safe and well-tolerated.
For this study, patients took 6 capsules per day of a product
containing 150 mg of butcher’s broom for 3 days and then
reduced their dose to 4 capsules per day. Statistically significant
improvement in a variety of symptoms (such as pain, local signs,
overall severity, etc.) was seen after 7 days of treatment. While a
single study does not prove efficacy, the very favorable observa-
tions of treating physicians combined with a long history of clini-
cal use are reasons to recommend that patients consider using
butcher’s broom as an internal treatment for hemorrhoids.
Butcher’s broom has been studied for use in pregnancy-related
varicosities. Two studies on pregnancy-related venous insuffi-
ciency both showed improvement in maternal symptoms with-
out any negative effects on the fetus.6,7 Two additional European
studies, one a multicenter study of 124 patients, showed a similar
reduction of symptoms in pregnant women.8,9 These studies do
not establish the safety of ruscus in pregnancy conclusively but
both animal and human studies indicate that ruscus has a high
degree of safety. Based on these studies, we favor butcher’s
broom when an internal remedy is needed for treating hemor-
rhoids in pregnant women (when surgical treatments are often
contraindicated).
In most clinical studies using this herb, the researchers gave
the subjects 150 mg of butcher’ broom, 3 times per day with
meals; the typical alcoholic tincture dose is 30–60 drops (1.5–3.0
mL) 3 times per day.10
Horse Chestnut
Horse chestnut is a beautiful deciduous tree that produces
large chestnut-like seeds that are dried for medicinal use. The
seeds contain a complex mixture of triterpene saponins collec-
tively referred to as escins (or as aescins).11 It also contains
flavonoids and tannins.12 The German Commission E has
approved the use of a standardized horse chestnut extract (con-
taining 16–20 percent anhydrous escin) for treating chronic
venous insufficiency (CVI).
Horse chestnut is the most widely prescribed oral remedy for
venous edema in Germany. Although widely used in Europe, the
herb’s popularity as a remedy in the United State is fairly recent.
286 ALTERNATIVE & COMPLEMENTARY THERAPIES—DECEMBER 2005
*Many of the studies on butcher’s broom combine it with various
flavonoids. There are, however, studies showing that butcher’s broom has
an action independent of these additional compounds. Some studies hint
that butcher’s broom used alone may actually have a stronger effect while
other studies indicate that the combinations may have a positive synergis-
tic effect. Thus, clinical results might be improved by the addition of com-
pounds such as trichalcone, ascorbic acid, and other flavonoids.
It should not be surprising to practitioners that patients suffering from
venous congestion problems may benefit from an overall treatment plan
that includes a variety of flavonoids and other compounds to reduce cap-
illary fragility and enhance healing.
Witch hazel (Hammamelis virginiana) flowers. Drawing © by Kathy
Abascal J.D., R.H. (A.H.G.).
Ta b l e 1. Staging of Internal Hemorrhoids
Stage Symptoms
I Occasional discomfort and/or bleeding
but no obvious external abnormality
II Hemorrhoids protrude with defecation
but reduce spontaneously
III Hemorrhoids protrude and require digital
reduction
IV Hemorrhoids protrude and cannot be
reduced
Adapted from Anonymous. American Gastroenterological Association medical position
statement: Diagnosis and treatment of hemorrhoids. Gastroenterol 2004;126:1461–1462.
There are some 20 clinical trials on horse chestnut and CVI, all of
which demonstrated a positive effect.11 In these studies, the
herb’s adverse effects were mild and infrequent and it was found
to be as effective as rutoside, another common treatment for CVI
in Europe.
There are European publications from the late 1800s and early
1900s reporting that horse chestnut benefits patients who have
hemorrhoids but there are no recent studies on the use of the
whole botanical medicine for treating hemorrhoids. One double-
blinded placebo-controlled study on 80 patients suffering from
acute symptomatic hemorrhoids showed that 40 mg of aescin
administered three times per day, for up to 2 months, reduced
symptoms in 81 percent of the subjects (compared to 11 percent
in the placebo group) and a notable reduction in bleeding (95
percent versus 62 percent) and swelling (87 percent versus 38
percent) as shown via endoscopic examination.13
Symptom reduction typically was reported after 6 days of
treatment and improvement in the condition was shown via
endoscopy after 2 weeks. Herbalist Michael Moore, director of
the Southwest School of Botanical Medicine, considers horse
chestnut to be the preferred remedy for hemorrhoids in individu-
als who are highly active physically (Michael Moore, personal
communication).
High levels of physical activity move more blood to the skele-
tal muscles, reducing the flow of blood to the gastrointestinal
tract. Mr. Moore says that this can lead to malabsorption, consti-
pation, and hemorrhoids, and he has found horse chestnut com-
bined with increased dietary flavonoids to be particularly helpful
in these cases. A typical dose of horse chestnut is 250 mg (corre-
sponding to 100 mg of escin) 2 times per day with meals.
Stone Root
Many American herbalists favor stone root, a nonaromatic
mint family plant, as a treatment for symptomatic hemor-
rhoids. The Eclectic physicians found this herb particularly
useful in patients with signs of congestion (dark red or purple
tissue) and hemorrhoids.14 Overweight, physically inactive
individuals who eat a diet high in fats and sugars and low in
fruits, vegetables, and grains tend to develop this state of con-
gestion. In our experience, stone root will often rapidly resolve
hemorrhoid symptoms and we favor its use in these types of
individuals.
There is virtually no research on stone root, except for con-
stituent studies showing that it contains flavonoids and
saponins.15,16 Of course, isolated flavonoids have been shown to
be of benefit for patients with hemorrhoids,17 and both butcher’s
broom and horse chestnut also contain flavonoids and saponins.
These data lend some very vague support for the use of stone
root. The Eclectics used a fairly low dose of stone root (1–30
drops); presently a typical dose of stone root tincture is 2–4 mL, 3
times per day.10,14
Witch Hazel
Witch hazel also has a long history of use as a hemorrhoid
treatment. Witch hazel is a shrub or small tree indigenous to
North America. The plant’s yellow flowers appear in the Fall,
and the leaves and bark are harvested for medicinal use. Both
the leaves and the bark contain tannins, primarily hamamelitan-
nins, and also contain catechins. The leaves contain more
flavonoids than the roots, and both contain a small amount of
volatile oil.12
Today, many people think of witch hazel primarily as a topical
treatment (see below). However, both European and American
herbalists typically use witch hazel both as an internal and topi-
cal remedy for hemorrhoids. Thus, both the European Scientific
Cooperative on Phytotherapy and France have approved the
herb’s combined use for treating hemorrhoids.12
Witch hazel is frequently prescribed as a decoction or as an
alcohol-preserved decoction. This makes sense as tannins are
highly soluble in hot water. Witch hazel extract has produced
anti-inflammatory, astringent, and vasoconstrictive properties in
pharmacologic studies.12 Its astringency is of help for patients
with bleeding hemorrhoids, and the Eclectics favored it for such
hemorrhoids as well as for any type of passive bleeding.14 The
ALTERNATIVE & COMPLEMENTARY THERAPIES—DECEMBER 2005 287
Calendula (Calendula officinalis). Horse chestnut (Aesculus hippocastanum).
Chamomile (Matricaria recutita).
dose for an infusion is 2–3 g of leaf or bark steeped in 150 mL of
boiled water, taken 2–3 times per day between meals. The tinc-
ture dose is 2–4 mL, 3 times per day.
Topical Treatments
Topical treatments to assist locally in calming inflammation
and for stopping bleeding and swelling are highly useful in
hemorrhoid treatment. According to the late Rudolf Fritz
Weiss, M.D. (a German phytotherapist and medical doctor),
acute hemorrhoidal inflammation is best treated with wet com-
presses.18 In addition, ointments can be applied but he did not
consider them to be sufficient if used alone. He recommended
that the compresses be cool, below room temperature, but not
cold because cold compresses can induce rectal spasming. Dr.
Weiss recommended that the wet compresses be applied for at
least 1 hour, morning and night, or that a sitz bath be used.
A hemorrhoid ointment should then be applied after each
treatment and after every bowel movement. As a practical mat-
ter, only a client with severe symptoms is likely to dedicate that
amount of time to treatment. Milder cases may be dealt with
effectively by a shorter time for compress application and an
occasional sitz bath with regular applications of ointment. Sup-
positories also work well.
Dr. Weiss favored arnica (Arnica spp.)compresses, which he
considered to be one of the fastest remedies for acute hemorrhoid
inflammation. He recommended using 1–2 teaspoons of arnica
tincture per half-liter of water for compresses. Alternatively, he
recommended the use of an oak bark decoction or a chamomile
infusion. He typically followed the application of compresses
with a witch hazel ointment.18
Topical application of witch hazel alone will often suffice to
soothe minor symptoms of acute inflammation. No doubt its
effectiveness explains why witch hazel remains a common ingre-
dient in over-the-counter hemorrhoidal preparations. Prepara-
tion H®Hemorrhoidal Cooling Gel (Wyeth, Madison, New
Jersey) for instance, contains 50 percent witch hazel. It is witch
hazel’s tannins that provide many aspects of its healing power,
and the clear witch hazel distillate so readily available over the
counter is not the medicine of choice because it is almost com-
pletely devoid of tannins.12 Instead, a more colorful tea or tinc-
ture should be used.
We tend to prefer combining several herbs in the compresses,
sitz baths, or ointments to provide a broader range of actions.
Any of the herbs used internally (stone root, butcher’s broom,
horse chestnut, and witch hazel) can be combined effectively for
topical application. We also like to include herbs that are noted
for their wound-healing properties, such as gotu kola, chamomile,
or calendula. If needed, tinctures of these herbs can be worked
into a cream base for topical application.
The Broader View of Hemorrhoid Treatment
Addressing hemorrhoids should go beyond simply prescribing
the botanicals discussed above. Dietary issues, while beyond the
scope of this article, are of great importance. Surprisingly little
research has been done on the connection between diet and hem-
orrhoids given the prevalence of the disorder and the fact that
isolated flavonoids have shown substantial benefit in the treat-
ment of hemorrhoids.17 Studies on fiber and hemorrhoids have
focused on the effect of soluble fiber; adding soluble fiber has
shown benefit in hemorrhoid treatment, at least when constipa-
tion is an aggravating factor.19
As a general rule, we consistently recommend that our clients
increase their intake of fruits and vegetables, with an emphasis
on foods containing soluble fiber. When constipation is an issue,
we often recommend psyllium seed husks. Lifestyle changes that
include increasing water intake and exercise to increase muscle
tone also help effect a long-term reduction of hemorrhoid symp-
toms.
As mentioned above, using botanicals both internally and top-
ically will speed healing. Botanicals such as gotu kola or ginkgo
(Ginkgo biloba), used to increase peripheral circulation, can act
synergistically with herbs used specifically for treating hemor-
rhoids.20 For instance, gotu kola and its isolated triterpenic frac-
tion improve microcirculation, decrease capillary permeability,
and reduce symptoms of CVI.21,22 The herb also has been shown
to increase tensile strength, collagen content, and epithelializa-
tion in many types of wounds when used internally or
topically.23–25
Dr. Weiss commented that it is important to address adequate-
ly the constipation and pain that accompanies many hemor-
rhoids as well.18 He typically prescribed a tea that combined
laxative, anti-inflammatory, and antispasmodic herbs with a bit-
288 ALTERNATIVE & COMPLEMENTARY THERAPIES—DECEMBER 2005
Dr. Rudolf Fritz Weiss’ Hemorrhoid Tea
Instructions
Use 1–2 tsp in a cup of boiling water infused for 10 minutes; patient should drink 1 cup in the morning and 1 cup at night.
Common name Latin binomial Part used Percentage
Chamomile Matricaria recutita Flowers 20%
Calamus Acorus calamus Root 20%
Fennel Foeniculum officinalis Seed 20%
Senna Senna spp. Leaves 20%
Frangula Frangula alnus Bark 20%
Adapted from ref. 18.
ter herb to tone the plexus hemorrhoidalis and an astringent to
relieve bleeding. One of his tea formulas is in the box entitled Dr.
Rudolf Fritz Weiss’ Hemorrhoid Tea..
A comprehensive treatment plan will work effectively on hem-
orrhoids in the early stages. More complicated or advanced hem-
orrhoids are likely to require allopathic intervention.
Nonetheless, botanicals as an adjunct to ligation and surgery will
be helpful for healing and preventing recurrences.
References
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Kathy Abascal, B.S., J.D., R.H. (A.H.G.), is executive director of the
Botanical Medicine Academy, Vashon, Washington. Eric Yarnell, N.D.,
R.H. (A.H.G.), is president of the Botanical Medicine Academy, a special-
ty board for using medicinal herbs, and is an adjunct faculty member at
Bastyr University, Kenmore, Washington.
To order reprints of this article, write to or call: Karen Ballen, ALTERNA-
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ALTERNATIVE & COMPLEMENTARY THERAPIES—DECEMBER 2005 289
... Nutritional therapy and plant treatments are effective and safe therapy for hemorrhoids (MacKay, 2001), although studies have been poorly for botanical treatments of hemorrhoids (Abascal and Yarnell, 2005). Several plant extracts shown to improve vascular tone, capillary flow, strengthen and microcirculation connective tissue of the perivascular amorphous substrate (MacKay, 2001). ...
... Several plant extracts shown to improve vascular tone, capillary flow, strengthen and microcirculation connective tissue of the perivascular amorphous substrate (MacKay, 2001). They can potentially use in treatment of hemorrhoids due to properties anti inflammatory, antioxidant and anti Several people are using plants in various forms, as orally or topically but only few plants are studied in scientifically (Abascal and Yarnell, 2005). called "Madimak" is an endemic plant f Polygonaceae and is widely consumed cognatum used as anti-inflammatory effect and a r biologic oxidation (Inaltong, 2015). ...
... Despite this decrease, plasma anal malondialdehyde and myeloperoxidase levels increased in this group. In contrast plasma catalase, glutathione peroxidase and superoxide dismutase activity and recto-anal glutathione, catalase, glutathione peroxidase and superoxide dismutase activity were anal malondialdehyde and myeloperoxidase Polygonum cognatum Meissn extract can play an anal tissue damage and oxidative stress that can be concerned with modulating of antioxidant molecule activities in rat of hemorrhoid which can be used safely for the treatment of ion of patients who do not want to undergo surgery and do not want Polygonum cognatum Meissn extract can play an anal tissue damage and oxidative stress which may be related to modulating the is an open access article distributed under the Creative Commons Attribution License, which permits Nutritional therapy and plant treatments are effective and safe therapy for hemorrhoids (MacKay, 2001), although studies have been poorly for botanical treatments of hemorrhoids (Abascal and Yarnell, 2005). Several plant extracts have been shown to improve vascular tone, capillary flow, strengthen and microcirculation connective tissue of the perivascular amorphous substrate (MacKay, 2001). ...
... Anorectal diseases are classified as commonest, less common and uncommon anorectal diseases, given in Table 1 7,8,9 . ...
Chapter
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The purpose of the study is to gather and compile information about anorectal disorders and the medications from various systems that are used to treat them. Anorectal disorders are a group of medical disorders in the rectum and anal regions. 25% of the world's population is affected by these disorders. The defects in structure and function of the anorectal and pelvic floor have been seen in patients suffering from a complication such as troubled defecation, fecal incontinence, bleeding from the rectum, anorectal stress, pain, discomfort, and prolapsed. Treatment of anorectal conditions has been known since ancient times by using various systems. The article describes the mechanism of the pathophysiology of common anorectal diseases hemorrhoids, anal fissure, anal fistula, rectal prolapse, & anal abscess, and the description of drugs used for the diseases in the ayurvedic, homeopathic, and allopathic systems of medicines on a majority basis.
... It is highly used in Europe for the treatment of hemorrhoids. According to Abascal and Yarnell, (2005), the effective those of Aesculus hippocastanum in clinical trial is 250 mg (corresponding to 100 mg of Aescin) 2 times per day with meals. ...
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Ethnopharmacology relevance Graptophyllum pictum (L.) Griff., known as “handeuleum” in West Java and “Daun Ungu” in Indonesia, is traditionally used to cure hemorrhoids. Aim of the study The purpose of this study is to prove its effectiveness scientifically using anorectal histological parameters in Croton oil-induced hemorrhoid mice. Materials and methods In vivo tests were performed by observing histomorphologic changes in mice anorectal tissue induced by croton oil. In addition, in vitro assay was performed for evaluating antioxidant activity, astringency property, and hemostasis-associated activity. The antioxidant activity was measured using a DPPH radical scavenging assay. The total flavonoid and phenolic contents were also determined spectrophotometrically. Results The in vivo assay showed that the oral-topical combination use of the ethanolic extract of G. pictum leaves demonstrated significant improvement on the croton oil-induced anorectal damage better than the single application by oral or topical application. Conclusion These results showed that G. pictum has potent anti hemorrhoid activity, especially for the combinational use of oral and topical administration.
Chapter
Drug likeness is a qualitative conception applied in drug design for how “drug-like” an element is related to factors such as bioavailability and extensively incorporated into the initial phases of lead and drug discovery. It is projected from the molecular structure earlier that the substance is at least synthesized and tested. A traditional technique to estimate drug likeness is to verify compliance of Lipinski’s Rule of Five, which contains the amounts of hydrophilic groups, molecular weight, and hydrophobicity. Methods to recognize drug-like molecules are grounded on their capability to discriminate known drugs from nondrugs in the groups of compounds by associating with one or more of the succeeding extensively available drug databases. There are different databases to categorize drug-like molecules which are based on their capability to discriminate known drugs from nondrugs in the set of compounds and have different methods to assess the drug likeness. The concept of drug likeness has numerous applications in drug discovery.
Chapter
Molecular docking is a computational tool of the molecules of complexes molded by different interactions of molecules. The aim of molecular docking is to predict the 3D structure. Molecular docking shows a significant role in the coherent design of drugs. To achieve an optimized conformation for both the protein and ligand, and relative orientation amongst protein and ligand, several types of docking are used often such as rigid docking, flexible docking, and full flexible docking so that the free energy of the overall system is minimized. De-novo drug design is a process in which the 3D structure of receptor is used to design newer molecules. It involves structural determination of the lead target complexes and lead modifications using molecular modeling tools.
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A new flavonoid, 2,5-dihydroxy-6,7-dimethoxyflavanone (1), was isolated from the leaf and stem exudates of Collinsonia canadensis along with three known flavones, baicalein-6,7-dimethyl ether (2), norwogenin-7,8-dimethyl ether (3), and tectochrysin (5-hydroxy-7-methoxyflavone).
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Akeboside St(b) [1) and two new saponins named collinsonin and collinsonidin were isolated from the roots of Collinsonia canadensis. On the basis of chemical and spectral studies, the structure of collinsonin [2] has been established as 3-O-alpha-L-ambinopymnosylcollinsogenin. 16-alpha-Hydroxyhederagenin, obtained by the hydrolysis of 2, is a new sapogenin named collinsogenin [5]. Collinsonidin [6] has been identified as 3-0-beta-D-glucopyranosyl-(1'-->3')-alpha-L-arabinopyranosylhederagenin.
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Sixty-seven patients with bleeding Grade 1 hemorrhoids were allocated alternately to receive either injection sclerotherapy or a bulk laxative. In either treatment group one third of patients was constipated with passing hard stools. At 2 weeks, 4 weeks and half a year information on the outcome was obtained from diaries kept by the patients. Injection sclerotherapy proved to be clearly superior than the use of bulk laxative. 36%, 23% and 35% compared to 59%, 58% and 72%, respectively, continued to bleed. An unexpected findings was noted among the constipated. Statistical significance could not be obtained, but the use of bulk laxative may show perhaps even better results than injection sclerotherapy. At 4 weeks and after half a year, the rates were 33% and 36% compared to 50% and 60%, respectively. Among the non-constipated patients injection sclerotherapy is the treatment of choice. At 4 weeks and half a year, only 10% and 24% were still bleeding. When a bulk laxative was taken, the effect was negligibly small. 74% and 94%, respectively, showed no response. Recurrences were fewer after injection sclerotherapy. 21% of patients free of bleeding at 4 weeks became symptomatic again in the following 5 months compared to 54% of such patients using bulk laxative. Again, bulk laxative was of little use in patients without the complaint of constipation, but was as effective as injection sclerotherapy among the constipated. These results are in line with prior histological investigations detailing the value of injection sclerotherapy. However, they are in contrast to a report showing that injection sclerotherapy plus bulk laxative is not more effective than the use of bulk laxative alone. They are also different from a meta-analysis of 18 randomized, controlled clinical trials recommending rubber band ligation as the initial treatment of Grade 1 to 3 hemorrhoids. In addition to showing the place of injection sclerotherapy and bulk laxative in the treatment of Grade 1 lesions, the results of the present investigation emphasize the need to ensure comparability between studies by using similar treatment groups and to monitor bowel habits. Zusammenfassung 67 Patienten mit Hmorrhoiden Grad 1 und Blutungen wurden alternierend einer Sklerosierungsbehandlung oder einer Stuhlgangsregulierung mit ballaststoffreicher Kost unterzogen. Der Anteil der Patienten mit Obstipation war in beiden Gruppen mit jeweils einem Drittel gleich. Nach zwei und vier Wochen bzw. einem halben Jahr wurden die Behandlungsergebnisse anhand der von den Patienten gefhrten Tagebuchkarten ermittelt. Die Sklerosierungsbehandlung erwies sich der Stuhlgangsregulierung mit ballaststoffreicher Kost berlegen. Jeweils 36%, 23% und 35% gegenber 59%, 58% und 72% gaben noch Blutungen an. Zu aussagekrftigen Ergebnissen kommt man aber erst bei Bercksichtigung der Stuhlgangsqualitt Sklerosierungsbehandlung ist bei Nichtobstipierten die Methode der Wahl. Nach vier Wochen bzw. einem halben Jahre zeigten nur noch 10% bzw. 24% der Patienten Blutungen. Fr ballaststoffreiche Kost ergab sich hingegen nur ein geringer Effekt. Bei 74% bzw. 94% der Patienten sistierten die Blutungen nicht. Fr Obstipierte waren bei kleinen Fallzahlen die Ergebnisse mit Sklerosierungsbehandlung und ballaststoffreicher Kost nicht signifikant unterschiedlich. Die Raten lagen bei 50% und 60% bzw. 33% und 36%. Vermutlich wren bei Obstipation stets eine Kombinationstherapie mit Sklerosierungsbehandlung und ballaststoffreicher Kost angebracht. Rezidive waren nach Sklerosierungsbehandlung selten: Bei 21% der Patienten, die nach vier Wochen ohne Blutungen waren, traten in den folgenden fnf Monaten Blutungen auf; bei ballaststoffreicher Kost waren es dagegen 54%. Bei Nichtobstipierten senkte ballaststoffreiche Kost die Rezidivrate nicht, whrend bei Obstipierten ballaststoffreiche Kost und Sklerosierungsbehandlung gleich wirksam waren. Die Ergebnisse stehen mit histologischen Untersuchungen im Einklang, die den Wert der Sklerosierungsbehandlung hervorheben, widerlegen aber eine Mitteilung, dass Sklerosierungsbehandlung und ballaststoffreiche Kost nicht wirksamer sind als ballaststoffreiche Kost allein. Sie weichen auch von einer Metaanalyse von 18 randomisierten klinischen Untersuchungen ab, aufgrund derer die Gummibandligatur als initiale Therapie fr Hmorrhoiden der Grade 1 bis 3 empfohlen wurde. Die vorliegende Untersuchung hebt die Notwendigkeit hervor, fr die Vergleichbarkeit von Studien hnliche Behandlungsgruppen zu benutzen und die Stuhlgangsqualitt zu bercksichtigen.
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The drug "Titrated Extract from Centella asiatica" (TECA), used for its stimulating properties on the healing of wounds, is a mixture of 3 terpenes extracted from a tropical plant: asiatic acid (30%, w/w), madecassic acid (30%, w/w) and asiaticoside (40%, w/w). The effects of TECA and its individual components were checked on human foreskin fibroblast monolayer cultures. TECA increased the collagen synthesis in a dose-dependent fashion whereas a simultaneous decrease in the specific activity of neosynthesized collagen was observed. Asiatic acid was found to be the only component responsible for collagen synthesis stimulation. TECA and all three terpenes increased the intracellular free proline pool. This effect was independent of the stimulation of collagen synthesis.
Article
Type I and III collagens are the major components of skin dermis. Skin aging is related mainly to a decrease in type I collagen levels. Collagen I also plays an important role in wound healing. An enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of secretion of type I and III collagen in human fibroblast cultures with or without asiaticoside and madecassoside. Normal adult dermal fibroblast cultures were established using the explant method from a skin (lifting) sample obtained from a 50 year-old woman. Fibroblasts were grown to confluence in supplemented E 199 medium and after 24 hours of growth, products were added in serum free medium containing 0.15 mM sodium ascorbate. The media were then collected and type I and III collagen secretion levels determined. Kinetics of type I and III collagen secretion led to determine the effects to asiaticoside and madecassoside after 48 hours for collagen I secretion and 72 hours for collagen III. Two triterpenes with an ursenoic skeleton, asiaticoside and madecassoside, were shown to stimulate collagen secretion. Type I secreted collagen (for 10(4) fibroblasts per 48 hours) was increased for 25-30% with asiaticoside and madecassoside. Interestingly, only Madecassoside was able to increase significantly collagen III secretion.
Article
In 87 patients with chronic venous hypertensive microangiopathy the efficacy of oral FTTCA (Centella asiatica) administered for 60 days was tested. The microcirculatory effects of two dosages (30 mg bid and 60 mg bid) versus placebo was assessed in a double blind study. The compound was well tolerated and no unwanted effects were observed. Microcirculatory parameters--peri-malleolar skin flux at rest (RF) and transcutaneous PO2 and PCO2--improved as did the abnormally increased RF, PCO2 decreased and PO2 increased in comparison with values measured at inclusion. These results confirm the efficacy of FTTCA in venous hypertensive microangiopathy. Furthermore the effects of FTTCA appear to be dose-related.