An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity

Molecules (Impact Factor: 2.42). 04/2008; 13(4):716-728. DOI: 10.3390/molecules13040716
Source: DOAJ


Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields, to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. This two step methodology improves upon previously described results. Poor e.e's resulted from our attempts to drive the enantioselectivity of this transformation by chiral amide induction.

Download full-text


Available from: Salvador none Gil, Mar 14, 2014