ChemInform Abstract: Synthesis of Optically Active 2-Methylchroman Derivatives and Application to Chiral Dopants for Nematic Liquid Crystals.

ChemInform (Impact Factor: 0.74). 03/2000; 73(1):259-265. DOI: 10.1246/bcsj.73.259


Chiral 2-methylchroman-2-carboxylic acid derivatives were prepared as new chiral dopants for nematic liquid crystals. The starting material, optically active 6-benzyloxy-2-methylchroman-2-carboxylic acid, was newly synthesized as a rigid core structure and resolved by a diastereomeric salt formation method. Its absolute configuration was determined by comparing its circular dichroism spectrum with that of the commercially available (S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid derivative. The helical twisting power of the new dopants was determined and the relationship between their functional groups and flexible terminal structures was studied.

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