Grover VK, Mathew PJ, Hegde H. Efficacy of orally disintegrating ondansetron in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: A randomised, double-blind placebo controlled study

Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Anaesthesia (Impact Factor: 3.38). 07/2009; 64(6):595-600. DOI: 10.1111/j.1365-2044.2008.05860.x
Source: PubMed


Peri-operative prophylactic anti-emetics are commonly used parenterally. Orally disintegrating ondansetron is efficacious during chemotherapy. Therefore, we aimed to study the efficacy of orally disintegrating ondansetron for postoperative nausea and vomiting. In a randomised, double-blind, placebo controlled trial on 109 patients scheduled for laparoscopic cholecystectomy, oral ondansetron was compared to intravenous ondansetron and placebo. The anaesthetic technique was standardised. Mean time (SD) to tolerating oral intake was delayed in the placebo group to 366.1 (77.6) min compared to oral 322.9 (63.7) min and intravenous 322.4 (65.2) min groups. This is corroborated by a higher incidence of nausea and vomiting in the control group during the first 6 h postoperatively (control 44.4%, oral 17.7%, intravenous 18.2%). There was no significant difference between oral and intravenous groups. In conclusion, orally disintegrating ondansetron was as efficacious as intravenous ondansetron in the peri-operative phase and may be a viable option for prophylaxis of emesis in day care surgery.

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    • "Ondansetron is a 5-HT3 receptor antagonist which has been documented to be an effective anti-emetic in preventing and treating PNOV with few side effects[12]. Orally disintegrating ondansetron has been shown to be effective in preventing chemotherapy induced nausea and vomiting[13, 14]. "
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    • "Its overall incidence can rise to 80% in high-risk patients.[1] The incidence of PONV remains unacceptably high (40-75% in the first 24hrs, without active intervention) following laparoscopic cholecystectomy.[23] "
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