Psychiatric and substance use disorders comorbidities in veterans with hepatitis C virus and HIV coinfection

Mental Health Division, Portland Veterans Affairs Medical Center, Portland, Oregon 97210, USA.
Current opinion in psychiatry (Impact Factor: 3.94). 06/2009; 22(4):401-8. DOI: 10.1097/YCO.0b013e32832cadb9
Source: PubMed


A growing number of veterans in the Veterans Health Administration are coinfected with HIV and hepatitis C virus. This review covers timely research relative to comorbid conditions that are common in this population including psychiatric diagnoses, substance use disorders and neurocognitive problems.
Current literature on the psychiatric, substance use disorders and cognitive problems of the coinfected population show that not only are rates of morbidity higher in the coinfected population but that this affects antiviral treatments as well. There is new evidence that brain injuries and infiltration of the virus into the central nervous system may be responsible for cognitive dysfunction. Cotesting, particularly in hepatitis C infected individuals, is not done routinely despite shared risk factors.
With this understanding of the comorbidities of the coinfected population, integrated healthcare models involving mental health, internal medicine, substance abuse treatment and internal medicine are crucial to work with these medically and psychologically complex patients.

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    • "The lack of sufficient mental health services in the HIV clinics amplified the providers' tendency to prescribe antidepressants and act as " therapists, " as one stated. Preventively prescribing antidepressants to patients on IRT because of insufficient psychiatric support (Weiss & Morgello, 2009), adopting a multidisciplinary approach that includes mental health and substance use services, and spending additional time with the patient (Fuller et al., 2009) were recently identified in the literature as essential for increasing IRT's uptake. Discussions of engaging their coinfected patients in HCV therapy revealed that providers integrated in their practice another key dimension of patient-centered medicine: understanding the meaning the illness has for the patient (Mead & Bower, 2000). "
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    ABSTRACT: Despite the high prevalence of hepatitis C virus (HCV) infection among injection drug users also infected with human immunodeficiency virus (HIV), and the synergistic adverse effect of the two diseases on patients' health and survival, research on the clinical management of these patients and particularly the low uptake of HCV therapy is limited. We conducted qualitative interviews with 17 HIV providers from two urban public hospitals. We discovered that the limitations of the current state of medical knowledge, the severe side effects of HIV and HCV therapies, and the psychosocial vulnerability of HIV/HCV-coinfected patients combined with their resistance to becoming informed about HCV posed significant challenges for providers. To contend with these challenges, providers incorporated key dimensions of patient-centered medicine in their practice, such as considering their patients' psychosocial profiles and the meaning patients assign to being coinfected, and finding ways to engage their patients in a therapeutic alliance.
    Preview · Article · Aug 2011 · Qualitative Health Research
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    ABSTRACT: Alcoholism and HIV-1 infection each affect components of selective attention and cognitive control that may contribute to deficits in emotion processing based on closely interacting fronto-parietal attention and frontal-subcortical emotion systems. Here, we investigated whether patients with alcoholism, HIV-1 infection, or both diseases have greater difficulty than healthy controls in resolving conflict from emotional words with different valences. Accordingly, patients with alcoholism (ALC, n = 20), HIV-1 infection (HIV, n = 20), ALC + HIV comorbidity (n = 22), and controls (CTL, n = 16) performed an emotional Stroop Match-to-Sample task, which assessed the contribution of emotion (happy, angry) to cognitive control (Stroop conflict processing). ALC + HIV showed greater Stroop effects than HIV, ALC, or CTL for negative (ANGRY) but not for positive (HAPPY) words, and also when the cue color did not match the Stroop stimulus color; the comorbid group performed similarly to the others when cue and word colors matched. Furthermore, emotionally salient face cues prolonged color-matching responses in all groups. HIV alone, compared with the other three groups, showed disproportionately slowed color-matching time when trials featured angry faces. The enhanced Stroop effects prominent in ALC + HIV suggest difficulty in exercising attentional top-down control on processes that consume attentional capacity, especially when cognitive effort is required to ignore negative emotions. (JINS, 2011, 17, 1-14).
    Full-text · Article · Mar 2011 · Journal of the International Neuropsychological Society
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