New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Steroids (Impact Factor: 2.64). 07/2009; 74(6):543-7. DOI: 10.1016/j.steroids.2009.02.004
Source: PubMed


Chemical investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L (1-4), together with a new 4alpha-methylated steroid, nebrosteroid M (5). The molecular structures of these isolated metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Compounds 1-5 were evaluated for anti-inflammatory activity using RAW 264.7 macrophages.

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