Article

Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects

Department of Psychiatry, The University of Western Ontario, London, ON, Canada.
Acta Psychiatrica Scandinavica (Impact Factor: 5.61). 06/2009; 121(1):33-40. DOI: 10.1111/j.1600-0447.2009.01391.x
Source: PubMed

ABSTRACT

The goal of this study was to investigate the relationship between default mode network connectivity and the severity of post-traumatic stress disorder (PTSD) symptoms in a sample of eleven acutely traumatized subjects.
Participants underwent a 5.5 min resting functional magnetic resonance imaging scan. Brain areas whose activity positively correlated with that of the posterior cingulate/precuneus (PCC) were assessed. To assess the relationship between severity of PTSD symptoms and PCC connectivity, the contrast image representing areas positively correlated with the PCC was correlated with the subjects' Clinician Administered PTSD Scale scores.
Results suggest that resting state connectivity of the PCC with the perigenual anterior cingulate and the right amygdala is associated with current PTSD symptoms and that correlation with the right amygdala predicts future PTSD symptoms.
These results may contribute to the development of prognostic tools to distinguish between those who will and those who will not develop PTSD.

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Available from: Richard Jim Neufeld, May 06, 2014
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    • "Studies investigating REM sleep before and after EMDR therapy would help answer the question of whether EMDR stabilizes altered REM sleep architecture. Likewise, although fMRI studies are scarce in EMDR, this strategy could help to better understand the brain changes associated with PTSD and the effects of therapy (Daniels et al., 2010; Lanius et al., 2010). For instance, a recently published case report of a bipolar subsyndromal, traumatized patient showed striking improvements in the Default Mode Network after EMDR therapy , suggesting therapy had a modulating effect (Landin-Romero et al., 2013). "

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