Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract

ArticleinFertility and sterility 92(3):1107-9 · June 2009with3 Reads
Impact Factor: 4.59 · DOI: 10.1016/j.fertnstert.2008.10.047 · Source: PubMed


    Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis.