The technological advance has been revolutionizing the way companies do business. The Internet as a source of these advances has become a powerful tool for business. The use of the Internet by enterprises encouraged the emergence of e-businesses that are business activities through the integration of communication technologies, business processes and management practices. The research about e-business is new and is under development. Thus, we sought to contribute in this field based on the following question: What is the impact of the Strategic Antecedents and Business Model in the Performance of Brazil’s companies e-business? In order to answer this question it was adopted as a general objective identifies the impact of the Strategic Antecedents and activities of the Business Model in the Performance of Brazilian’s companies in e-business. The specific objectives are: (i) identify and validate the measurement scale of the Strategic Antecedents, (iv) construct and validate a scale of the Business Model and (iii) construct a model to analyze the relationship between the constructs (Strategic Antecedents, Business Model and Performance). It was adopted as the theoretical support the TOE (Technological, Organizational and Environmental framework), arising from TDI (Theory of Diffusion of Innovations), to support the Strategic Antecedents (IFINEDO, 2011a), the Business Model (OSTERWALDER; PIGNEUR; TUCCI, 2005) and the literature about business Performance (RAMANUJAN; VENKATRAMAN, 1987). The Methodological procedures consist of validation of scales, descriptive statistics, multivariate analysis, this comprised of exploratory factor analysis, confirmatory factor analysis and structural equation modeling. The main results indicate partial influence of Strategic Antecedents on the Value Proposition that belongs to Business Model, through the constructs Positioning Management, Organizational Readiness, Relative Advantage and Pressure from Stakeholders. Concerning Business Model, the constructs Market Segmentation, Customer Relations, Capabilities, Partnerships and Revenue Model influence the Value Proposition and this has an impact on the performance of e-business companies. It is noteworthy validation and construction of the scale of the Strategic Antecedents and Business Models as a contribution to the field. It is suggested for future studies in suitable settings and scales created in this research, replicating this study in other states of Brazil, comparing samples from other states, comparisons at international levels, and the use of other statistical techniques such as MANOVA and logistic regression.