ProtVirDB: A database of protozoan virulent proteins

Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Bioinformatics (Impact Factor: 4.98). 05/2009; 25(12):1568-9. DOI: 10.1093/bioinformatics/btp258
Source: PubMed


ProtVirDB is a comprehensive and user-friendly web-based knowledgebase of virulent proteins belonging to protozoan species. The database will facilitate research and provide an integrated platform for comparative studies of virulent proteins in different parasitic protozoans and organize them under a unifying classification schema with functional categories. Remarkably, one-third of the protein sequences in the database showed presence of either mono- or hetero-repeats, or both concomitantly--hence reiterating the importance of repeats in parasite virulence mechanisms. A number of useful bioinformatics tools including BLAST and tools for phylogenetic analysis are integrated with the database. With the rapidly burgeoning interest in the pathogenesis mechanisms of protozoans and ongoing genome sequencing projects, we anticipate that the database will be a useful tool for the research community. AVAILABILITY: SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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Available from: Dinesh Gupta, Nov 21, 2015
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    • "However, biochemical evidence for N-and O-glycosylation in these apicomplexan parasites has been described (Macedo et al. 2010), and suppression of this process is associated with reduced motility and loss of capacity for invading host cells (Luk et al. 2008). It has also been demonstrated that serine-and asparaginerich repeats have high incidences in eukaryotes, including protozoan parasites (Ramana and Gupta 2009). The study by Ramana and Gupta showed, however, that asparagine residues present at N-glycosylation sites are suppressed in repeats when compared with nonrepetitive sequences of obligate parasites. "
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