Not at random location of atherosclerotic lesions in thoracic aorta and their prognostic significance in relation to the risk of cardiovascular events

III Department of Cardiology, Medical University of Silesia, Katowice, Silesian Center for Heart Diseases, Zabrze, Poland.
Polish Journal of Radiology 02/2013; 78(2):38-42. DOI: 10.12659/PJR.883944
Source: PubMed


Thoracic aortic calcium deposits are frequently detected on tomography of the chest, and in other imaging modalities. Numerous studies indicated the correlation of hemodynamic parameters such as wall shear stress in relation to distribution aortic calcifications. This publication discusses similarities and differences of two distinct pathomechanisms of arterial calcifications: intimal associated with atherosclerosis and medial knows as Mönckeberg's arteriosclerosis. This review also analyzes the frequent coexistence of aortic calcification and coronary artery disease in terms of risk of cardiovascular events.

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Available from: Jarosław Wasilewski, Jul 21, 2014
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    ABSTRACT: Background: Atherosclerosis is a systemic process associated with arterial calcification in multiple vascular beds. This study investigated correlations between aortic root calcification (ARC) quantified using Agatston and volumetric scoring methods with coronary atherosclerotic markers (coronary artery calcification (CAC), calcified plaques and luminal stenosis). materials and methods: This cross-sectional study was carried out between January and December 2013. One hundred ninety-six consecutive patients with intermediate pretest probability of ischemic heart disease who underwent 64-slice multi-detector computed tomography angiography were recruited, with 175 being eligible to enroll in the study. Results: A significant correlation was observed between ARC and total CAC using the Agatston and volumetric methods (r=0.225, P=0.003; and r=0.243, P=0.001, respectively). With regard to individual coronary vessel calcification and ARC, a significant correlation was observed between ARC and left main stem artery calcification calculated using the volumetric and Agatston methods (P<0.05). A significant correlation was observed between high ARC and coronary calcified plaque presence measured using the Agatston and volumetric scoring methods. A strong correlation was also observed between ARC and number of coronary stenotic vessels measured using the Agatston and volumetric scoring methods (r=0.67, P<0.001; and r=0.63, P<0.001, respectively). Conclusion: ARC can be used as an additional marker to assess coronary atherosclerosis and may have a complementary role with CAC for detection of coronary artery disease.
    No preview · Article · Nov 2014 · Academic Radiology