A cluster of microcalcifications: Women with high risk for breast cancer versus other women

Department of Breast Imaging and Breast Intervention, Breast Center, Shizuoka Cancer Center Hospital, Naga-izumi, Shizuoka 411-8777, Japan.
Breast Cancer (Impact Factor: 1.59). 05/2009; 16(4):307-14. DOI: 10.1007/s12282-009-0100-5
Source: PubMed


Abnormal screening mammographic findings are the most common presentation of ductal carcinoma in situ, which usually appears as a cluster of microcalcifications. No report has documented the risk of malignancy between the finding of a cluster of microcalcifications and women with high risk of breast cancer.
We investigated the morphologic descriptors of a cluster of microcalcifications in women with a high risk for breast cancer and compared the results with the characteristics of a cluster of microcalcifications in other women. A retrospective review was performed for 81 non-palpable clusters of microcalcifications that had stereotactic vacuum-assisted breast biopsy.
The frequency of malignancy associated with a cluster of microcalcifications was 27%. The 50% frequency of malignancy with high risk for breast cancer was higher, but not significantly so, than the 24% frequency of 71 cases without high risk for breast cancer (P = 0.125). The frequency of malignancy and ADH of a cluster of microcalcifications with high risk of breast cancer was 70%, significantly higher than the 30% frequency of 71 cases without high risk of breast cancer (P = 0.028).
A cluster of microcalcifications in women with high risk for breast cancer should be considered suspicious and referred for biopsy.

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