Rubella seroprevalence in pregnant women in North Thames: Estimates based on newborn screening samples

Statistics Unit, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK.
Journal of Medical Screening (Impact Factor: 3.1). 02/2009; 16(1):1-6. DOI: 10.1258/jms.2009.008080
Source: PubMed


Routine screening for rubella susceptibility is recommended in the UK so that women found to be susceptible can be offered immunization in the post partum period. We demonstrate the use of newborn dried blood spot samples linked to routine vital statistics datasets to monitor rubella susceptibility in pregnant women and to investigate maternal characteristics as determinants of rubella seronegativity.
North Thames region of England (including large parts of inner London).
Maternally acquired rubella IgG antibody levels were measured in 18882 newborn screening blood spot samples. Latent class regression finite mixture models were used to classify samples as seronegative to rubella. Data on maternal country of birth were available through linkage to birth registration data.
An estimated 2.7% (95% CI 2.4%-3.0%) of newly delivered women in North Thames were found to be seronegative. Mothers born abroad, particularly in Sub-Saharan Africa and South Asia, were more likely to be seronegative than UK-born mothers, with adjusted odds ratios of 4.2 (95% CI 3.1-5.6) and 5.0 (3.8-6.5), respectively. Mothers under 20 years were more likely to be seronegative than those aged 30 to 34.
Our findings highlight the need for vaccination to be targeted specifically at migrant women and their families to ensure that they are protected from rubella in pregnancy and its serious consequences.

Download full-text


Available from: Catherine Peckham
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To examine rubella seroepidemiology, and estimate rates of catch-up immunisation and persistence of antibody titers in pregnant women in Taiwan after mass immunisation. A retrospective study. Two medical centres and four regional hospitals specialising in obstetric care. A total of 43,640 prenatal rubella test results for pregnant women from 2001 to 2008. Rubella immunoglobulin G (IgG) antibody assay. Seronegativity, rate of catch-up immunization, and antibody decline. The seronegativity was 10.9% in all pregnant women. Immigrant women had higher seronegativity than indigenous women (OR 2.86; 95% CI 2.65, 3.01). Indigenous women born prior to implementation of the vaccination programmes were more susceptible (20.1%) to rubella infection than were women born thereafter (6.7%). Rates of seropositive conversion were low in both Taiwanese-born and foreign-born women (11.5 and 30.7%, respectively). The rubella antibody titers for vaccinated Taiwanese women in the 1971-1976 and after-1976 birth cohorts declined by 0.6 and 2.3% per year, respectively. This study demonstrates high seronegativity of older indigenous and immigrant women, a low catch-up immunisation rate, and the persistence of rubella antibodies in Taiwan after mass vaccination. Our study suggests that a single dose of rubella vaccine in teenagers effectively increased rubella seropositivity during their childbearing years. This finding is useful for countries that lack the resources necessary for a two-dose regimen. We recommend free rubella antibody tests to women of childbearing age and free vaccination as required. All postpartum women testing negative for rubella antibodies should be vaccinated before they leave hospital.
    Full-text · Article · Mar 2011 · BJOG An International Journal of Obstetrics & Gynaecology

  • No preview · Article · Jul 2013 · BMJ (online)
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A National Programme to eliminate Measles and Congenital Rubella was implemented in Italy in 2003. It aimed to achieve elimination by 2010 in line with the targets set by the World Health Organization (WHO) European Region. The aim of this study was to determine the prevalence of rubella antibodies in samples of immigrant women living in southern Italy. A seroepidemiologic study was conducted from 1 January 2008 to June 30 2009. 489 immigrant women resident in Messina were enrolled in the study. The detection of rubella antibodies was performed using a microparticle enzyme immunoassay. A questionnaire was used to collect demographic data including age, country of origin, educational level and knowledge about rubella. The results of the seroepidemiological survey to detect rubella antibodies showed an overall seropositivity rate of 82.2%. Generally, knowledge about rubella and congenital rubella syndrome was lacking. Many immigrants are susceptible to rubella and may benefit from vaccination programmes. Additional catch-up vaccination strategies are urgently needed to eliminate the risk of congenital rubella syndrome for future generations.
    Full-text · Article · Jan 2014 · Travel Medicine and Infectious Disease
Show more