Epidemiology of interstitial lung diseases in Greece

2nd Department of Pneumonology, Medical School, University of Athens and "Attikon" University Hospital, Greece.
Respiratory medicine (Impact Factor: 3.09). 05/2009; 103(8):1122-9. DOI: 10.1016/j.rmed.2009.03.001
Source: PubMed


Few data are available on the epidemiology of interstitial lung diseases (ILDs), especially after the current classification of idiopathic interstitial pneumonias. The aim of this study is to provide data on the epidemiology of ILDs in Greece, under the ATS/ERS international consensus.
Departments of Pneumonology were contacted and asked to complete a questionnaire for every case of ILD that was alive on 2004 as well as for every new case from 1st January 2004 to 31st December 2004. Questions on the patients' demographic data, the exact diagnosis and the procedures used to establish the diagnosis were included. Centers covering about 60% of the Greek population have been analyzed.
A total of 967 cases have been registered. The estimated prevalence of ILDs is 17.3 cases per 100,000 inhabitants. The estimated annual incidence of ILDs is 4.63 new cases per 100,000 inhabitants. The most frequent disease is sarcoidosis (34.1%), followed in decreasing order by idiopathic pulmonary fibrosis (19.5%), ILD associated with collagen vascular diseases (12.4%), cryptogenic organizing pneumonia (5.3%), histiocytosis (3.8%), and hypersensitivity pneumonitis (2.6%). Unclassified ILD or not otherwise specified accounted for the 8.5% of prevalent cases.
These data suggest that sarcoidosis and idiopathic pulmonary fibrosis are the most frequent ILDs in our population. In comparison with the few previous reports, interesting dissimilarities have been observed.

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Available from: Demos Bouros, Feb 06, 2016
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    • "Moreover, thanks to the universal health care coverage and to the DENALI data warehouse, which traces a complete medical history of each resident in Lombardy by merging data of different datasets belonging to the same individual, we could investigate the prevalence and incidence of IPF in an unselected population, without restrictions related to age [11,13,31], adherence to some health plan (e.g. Medicare) [11,28], or voluntary recruitment [17,32]. In conclusion, our results on IPF prevalence and incidence are in line with those reported in other epidemiological studies conducted in Italy and Europe, and incidence and prevalence trends are in agreement with those reported in European and American studies. "
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    ABSTRACT: Background: Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of idiopathic interstitial pneumonia. Despite its clinical relevance, few studies have examined the epidemiology of IPF and temporal variation in disease incidence and prevalence. Aim of the study was to investigate the prevalence, incidence and trends of IPF in Lombardy, a region with nearly 10 million inhabitants, during 2005-2010. Methods: For the identification of IPF patients, we used healthcare administrative databases of Lombardy Healthcare System and adopted three algorithms: generic, broad and narrow case definition (GCD, BCD, NCD). IPF cases were identified according to diagnoses reported in inpatient and outpatient claims occurred during 2000-2010. We estimated age- and sex-adjusted annual prevalence and incidence rates from 2005 to 2010, thus allowing for a 5-year washout period. Results: The mean annual incidence rate was estimated at 2.3 and 5.3 per 100,000 person-years using NCD and GCD, respectively. IPF incidence was higher among males, and increased with age. Trend remained stable over the years. The estimated annual prevalence rate was 35.5, 22.4, and 12.6 per 100,000 person-years using GCD, BCD and NCD, respectively, and increased with age. Moreover, we observed a positive trend over the years. Using BCD and NCD, prevalence was higher among males. Conclusions: The results of this study, which is one of the largest population-based survey ever conducted according to strict criteria, indicated that prevalence of IPF increased across the years while incidence remained stable, thus suggesting that survival with IPF has improved.
    Full-text · Article · Feb 2016 · PLoS ONE
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    • "Study Mean/median age at Dg Male/ Female Total no of cases/ ATS/ERS 2000/2002 Before ATS/ERS 2000/2002 Re-evaluation % IPF of ILD Dg criteria used Thomeer et al. 2001 57 years 58/42% 362/20% X Liebow 1975 Tinelli et al. 2005 68 years 63/37% 3152/27% X Xaubert et al. 2004 511/38.6% X Karakatsani et al. 2009 967/20% X Hodgson et al. 2002 X X von Plessen et al. 2003 69.2 45/55 X Turner-Warwick X Gribbin et al. 2006 71 years 62/38% X Raghu et al. 2006 X Olson et al. 2007 X Ohno et al. 2008 65 years 1543/85.7% X Fernández Pérez et al. 2010 74 years X X Navaratnam et al. 2011 74 years 63/37% X Lai et al. 2012 X "
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    ABSTRACT: Recent studies suggest that the incidence of idiopathic pulmonary fibrosis (IPF) is rising. Accurate epidemiological data on IPF, however, are sparse and the results of previous studies are contradictory. This study was undertaken to gain insight into the various methods used in the epidemiological research of IPF, and to get accurate and comparable data on these different methodologies. A systematic database search was performed in order to identify all epidemiological studies on IPF after the previous guidelines for diagnosis and treatment were published in 2000. Medline (via Pubmed), Science Sitation Index (via Web of Science) and Embase databases were searched for original epidemiological articles published in English in international peer-reviewed journals starting from 2001. After pre-screening and a full-text review, 13 articles were accepted for data abstraction. Three different methodologies of epidemiological studies were most commonly used, namely: 1) national registry databases, 2) questionnaire-based studies, and 3) analysis of the health care system's own registry databases. The overall prevalence and incidence of IPF varied in these studies between 0.5--27.9/100,000 and 0.22--8.8/100,000, respectively. According to four studies the mortality and incidence of IPF are rising. We conclude that there are numerous ways to execute epidemiological research in the field of IPF. This review offers the possibility to compare the different methodologies that have been used, and this information could form a basis for future studies investigating the prevalence and incidence of IPF.
    Full-text · Article · Aug 2013 · BMC Pulmonary Medicine
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    • "Epidemiologic studies in Italy, Belgium, Greece, Spain, United States and Finland have revealed that the diagnosis has been confirmed by SLB in 28–38% of the cases [17-22]. Questionnaire-based national surveys have shown that in Greece and Spain approximately 31% of the patients with IPF were diagnosed by SLB [19,22]. In the major clinical trials conducted in the past decade, the current diagnostic criteria for IPF have been used which may provide some enlightenment on the frequency of SLB. "
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    ABSTRACT: A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively specific combinations of HRCT and surgical lung biopsy findings can be accepted. In about two third of the cases IPF can be diagnosed by clinical and radiological criteria. Thus surgical lung biopsy is needed in about one third of cases to achieve the ultimate diagnosis, which requires multidisciplinary cooperation. In large clinical trials conducted during the last decade, lung biopsy was performed in about 30--60% of the cases. The most serious complication of lung biopsy is mortality within 30 days after the procedure, with a frequency of about 3--4% reported in most studies. Because of the histological variability, surgical lung biopsy should be taken from a minimum of two lobes. The number of fibroblast foci in surgical lung biopsy has been shown to correlate with survival in several studies.
    Full-text · Article · Apr 2013 · Respiratory research
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