Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

Article (PDF Available)inNature Genetics 41(5):521-3 · April 2009with60 Reads
DOI: 10.1038/ng.349 · Source: PubMed
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.