Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: The JACC Study. Sleep, 32, 259-301

Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Sleep (Impact Factor: 4.59). 04/2009; 32(3):295-301.
Source: PubMed


To examine sex-specific associations between sleep duration and mortality from cardiovascular disease and other causes.
Cohort study.
Community-based study.
A total of 98,634 subjects (41,489 men and 57,145 women) aged 40 to 79 years from 1988 to 1990 and were followed until 2003.
During a median follow-up of 14.3 years, there were 1964 deaths (men and women: 1038 and 926) from stroke, 881 (508 and 373) from coronary heart disease, 4287 (2297 and 1990) from cardiovascular disease, 5465 (3432 and 2033) from cancer, and 14,540 (8548 and 5992) from all causes. Compared with a sleep duration of 7 hours, sleep duration of 4 hours or less was associated with increased mortality from coronary heart disease for women and noncardiovascular disease/noncancer and all causes in both sexes. The respective multivariable hazard ratios were 2.32 (1.19-4.50) for coronary heart disease in women, 1.49 (1.02-2.18) and 1.47 (1.01-2.15) for noncardiovascular disease/noncancer, and 1.29 (1.02-1.64) and 1.28 (1.03-1.60) for all causes in men and women, respectively. Long sleep duration of 10 hours or longer was associated with 1.5- to 2-fold increased mortality from total and ischemic stroke, total cardiovascular disease, noncardiovascular disease/noncancer, and all causes for men and women, compared with 7 hours of sleep in both sexes. There was no association between sleep duration and cancer mortality in either sex.
Both short and long sleep duration were associated with increased mortality from cardiovascular disease, noncardiovascular disease/noncancer, and all causes for both sexes, yielding a U-shaped relationship with total mortality with a nadir at 7 hours of sleep.

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Available from: Satoyo Ikehara, Sep 15, 2015
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    • "More recently , epidemiological studies have suggested that a person's overall health is influenced by sleep patterns throughout life, with a positive association seen between shortened sleep duration and morbidity and mortality (Qureshi et al. 1997; Ayas et al. 2003; Ferrie et al. 2007; Ikehara et al. 2009; Luyster et al. 2012). People who report habitually short sleep durations, defined as sleep durations less than six hours each night, have an increased prevalence of type 2 diabetes, hypertension, obesity, cardiovascular disease, and stroke (Qureshi et al. 1997; Ayas et al. 2003; Schultes et al. 2005; Spiegel et al. 2005; Gottlieb et al. 2006; Ferrie et al. 2007; Cappuccio et al. 2008; Chen et al. 2008; Ikehara et al. 2009; Kim and Jo 2010; Sabanayagam and Shankar 2010; Luyster et al. 2012; Chaput et al. 2007). Further, a study in Finland found that workers engaged in shift work (SW), that is, work outside regular daytime hours, had a higher incidence of stroke suggesting some aspect of shift work increases the vulnerability of the brain (Nurminen and Karjalainen 2001). "
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    • "The study performed among 104,010 Japanese people aged from 40 to 79 years showed that sleep duration was a predictor of all-cause mortality among men and women (hazard ratios were slightly higher among females), but finally, in fully adjusted model, relation between short sleep duration and mortality was observed only among women (Tamakoshi and Ohno 2004). A later report of the Japanese cohort study showed a U-shaped relationship between sleep duration and all-cause mortality for both genders (Ikehara 2009). In one large study performed among people aged 30 and over in the USA, the results for males and females were also similar (Kripke et al. 2002), and the most recent critical review published by Kurina et al. (2013) has shown a lack of consistent differences between genders with regard to the association between sleep duration and mortality. "
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