In Vivo Analysis of Dendritic Cell Development and Homeostasis

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
Science (Impact Factor: 33.61). 04/2009; 324(5925):392-7. DOI: 10.1126/science.1170540
Source: PubMed


Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where
DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral
lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors
that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs).
Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC
network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine
kinase receptor-3.

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Available from: Pierre Guermonprez, Apr 22, 2014
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