Patterns of photoprotection following CDKN2A/p16 genetic test reporting and counseling

Department of Psychology, University of Utah, Salt Lake City, Utah, USA.
Journal of the American Academy of Dermatology (Impact Factor: 4.45). 03/2009; 60(5):745-57. DOI: 10.1016/j.jaad.2008.12.034
Source: PubMed


The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown.
To determine if genetic testing and counseling alter compliance with photoprotection recommendations.
Reported use of sunscreen, protective clothing, and sun avoidance by 59 members of CDKN2A/p16-mutation positive pedigrees was assessed as a function of mutation status and melanoma history, before, immediately after, and 1 month following test reporting.
Intentions to practice all photoprotective behaviors increased in all participant groups (P < .0001). At 1 month, 33% of participants reported the adoption of a new photoprotective behavior. Subpopulation analyses identified different patterns of change in photoprotection relative to baseline (P < .005), with no net decline in any group.
This initial study of CDKN2A/p16 families is small and awaits replication in a larger sample.
Melanoma genetic testing and counseling enhanced intentions to implement photoprotective strategies and did not result in reduced compliance in the CDKN2A/p16-subpopulation.

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