Quality of life in children and adolescents with obsessive-compulsive disorder: base rates, parent-child agreement, and clinical correlates. Social Psychiatry and Psychiatric Epidemiology, 44(11), 935-942

Department of Behavioral Sciences, Arkansas Tech University, Russellville, AR 72801, USA.
Social Psychiatry (Impact Factor: 2.54). 04/2009; 44(11):935-42. DOI: 10.1007/s00127-009-0013-9
Source: PubMed


The presence of obsessive-compulsive disorder (OCD) has been linked to decreased quality of life (QoL) among adults, yet little is known about the impact of OCD on QoL in pediatric patients. Sixty-two youth with OCD and their parent(s) were administered the Children's Yale-Brown Obsessive Compulsive Scale following a clinical interview. Children completed the Pediatric Quality of Life Inventory and parents completed the Pediatric Quality of Life Parent Proxy Inventory and Child Behavior Checklist. QoL scores for OCD patients were significantly lower than for healthy controls, but similar to QoL in a general psychiatric sample on the majority of domains. Parent-child agreement on QoL was moderate to strong across age groups. Results indicate that, in youth with OCD, QoL is reduced relative to healthy controls, related to OCD symptom severity per parent-report, and are strongly predicted by the presence of comorbid externalizing and internalizing symptoms.

Download full-text


Available from: Caleb W Lack
  • Source
    • "Youth show problematic peer relations, academic difficulties, and participate in fewer recreational activities than matched peers (Lack et al., 2009). Overall, there is a lower QoL in pediatric females than males, but in adults similar disruptions are reported. "

    Full-text · Chapter · Feb 2015
  • Source
    • "The PedsQL Total Score provides a metric of overall child-rated quality of life. Extensive validity and reliability data have been published across multiple clinical presentations in support of the PedsQL (e.g., Varni and Burwinkle, 2006; Lack et al., 2009). Multidimensional Anxiety Scale for Children (MASC; March et al., 1997). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Pharmacological and behavioral interventions have focused on reducing tic severity to alleviate tic-related impairment for youth with chronic tic disorders (CTDs), with no existing intervention focused on the adverse psychosocial consequences of tics. This study examined the preliminary efficacy of a modularized cognitive behavioral intervention ("Living with Tics", LWT) in reducing tic-related impairment and improving quality of life relative to a waitlist control of equal duration. Twenty-four youth (ages 7-17 years) with Tourette Disorder or Chronic Motor Tic Disorder and psychosocial impairment participated. A treatment-blind evaluator conducted all pre- and post-treatment clinician-rated measures. Youth were randomly assigned to receive the LWT intervention (n=12) or a 10-week waitlist (n=12). The LWT intervention consisted of up to 10 weekly sessions targeted at reducing tic-related impairment and developing skills to manage psychosocial consequences of tics. Youth in the LWT condition experienced significantly reduced clinician-rated tic-impairment, and improved child-rated quality of life. Ten youth (83%) in the LWT group were classified as treatment responders compared to four youth in the waitlist condition (33%). Treatment gains were maintained at one-month follow-up. Findings provide preliminary data that the LWT intervention reduces tic-related impairment and improves quality of life for youth with CTDs. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
    Full-text · Article · Dec 2014 · Psychiatry Research
  • Source
    • "Comorbid depression occurs in 35–40% of youth with OCD (Swedo et al., 1989), with increased severity of OCD being linked to worse depressive symptoms (Canavera et al., 2010; Langley et al., 2010; Peris et al., 2010). Depression exacerbates functional impairments and quality of life (Lack et al., 2009), and lead to complication of treatment outcomes for youth with OCD (Storch et al., 2008). Comorbid anxiety is even more prevalent than depression, occurring in 50–77% of youth with OCD (Ivarsson et al., 2008; Contents lists available at ScienceDirect journal homepage: "
    [Show abstract] [Hide abstract]
    ABSTRACT: Objectives: Youth with obsessive compulsive disorder (OCD) are at risk of experiencing comorbid psychiatric conditions, such as depression and anxiety. Studies of Chinese adolescents with OCD are limited. The aim of this study was to investigate the association of depression, anxiety, and helplessness with the occurrence of OCD in Chinese adolescents. Methods: This study consisted of two stages. The first stage used a cross-sectional design involving a stratified clustered non-clinical sample of 3174 secondary school students. A clinical interview procedure was then employed to diagnose OCD in students who had a Leyton ‘yes’ score of 15 or above. The second phase used a case-control study design to examine the relationship of OCD to depression, anxiety and helplessness in a matched sample of 288 adolescents with clinically diagnosed OCD and 246 students without OCD. Results: Helplessness, depression and anxiety scores were directly associated with the probability of OCD caseness. Canonical correlation analysis indicated that the OCD correlated significantly with depression, anxiety, and helplessness. Cluster analysis further indicated the degree of the OCD is also associated with severity of depression and anxiety, and the level of helplessness. Conclusion: These findings suggest that depression, anxiety and helplessness are important correlates of OCD in Chinese adolescents. Future studies using longitudinal and prospective designs are required to confirm these relationships as causal. Key words: depression, anxiety, helplessness, obsessive-compulsive disorders, Chinese adolescents
    Full-text · Article · Nov 2014 · Journal of Affective Disorders
Show more