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Commercial Glue Sniffing and Child Health: Indian Street Children are at a Risk

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Journal of Biosafety & Health Education
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Digital Object Identier: http://dx.doi.org/10.4172/jbhe.1000e108
Volume 1 • Issue 3 • 1000e108
J Biosafety Health Educ
ISSN: JBHE an open access journal
Editorial
Open Access
Biosafety & Health Education
Mondal, J Biosafety Health Educ 2013, 1:3
http://dx.doi.org/10.4172/jbhe.1000e108
Children are the source of hope and inspiration for the society. at
is why they have the right to be brought up in a positive environment.
But there are many children in the world who have become synonymous
with social deprivation at its worst. Children who are working and living
on the streets are found throughout the nation. Street children constitute
a marginalized population in most urban centers of the world. ere are
major diculties in trying to estimate the number of street children
and the magnitude of hardship they experience. In their marginalized
state they constitute a truly “hidden” population who were not covered
by nor nd place in the national census, educational or health data,
largely because they have no xed address [1]. is problem is further
compounded by the fact that they are also a highly mobile population.
However, it is speculated that between 100,000 and 125,000 children
live on the streets and railway stations of Indias major cities, and that
more than half of them have some form of drug addiction.
Street boys living at dierent Indian railway stations of West
Bengal, take care of themselves and each other in an otherwise uncaring
environment and surviving through begging, petty the or hawking
goods on the platforms. Most of the paltry sum they earn is spent on
tobacco or on tube of Glue (locally known as Dendritewhich is an
industrial contact adhesive and rubber cement brand marketed as
glue sticks, tubes and cans in India and South Asia, mainly in Eastern
India, Bangladesh and Bhutan) that is a particular favorite with those
children. is golden colored industrial glue (oen called as golden
glue’) containing organic solvents is cheap and readily available and
provides faster onset of action and the regular ‘high’ [2,3]. Investigators
believe that the addicts can be exposed to several thousand parts per
million (2,000-30,000 ppm) of organic solvents within a few minutes
[4]. e kids squeeze Glue onto a rag and hu its fumes through the
mouth.
Although these products are not classied as drugs because they
are not intended to be used to achieve intoxication, young children and
adolescents can easily obtain them and are among those most likely
to abuse them [5]. Besides addiction, they’re usually victims of abuse
and harassment, and are extremely vulnerable to tracking, sex trade
and child labor [6]. Inhalant abuse/dependence has been reported from
various parts of the world [7-10]. Drug usage among minors has created
a global generation of addicted and oen abandoned children bere of
family support, education and social skills. ere are epidemiological
reports indicating that chronic exposure to abuse solvents can produce
loss of appetite [5]; however, the mechanisms involved in these eects
are not well understood. Its sad that kids would come to that.
Our previous reports suggested that tobacco smoking and/or
chewing habit among street boys is associated with increased frequency
of micronucleus and γ-H2AX foci formation in oral mucosa, implying
chromosomal and DNA damage respectively [11]. Additional habit of
sning/hung of industrial glue enhances the severity of genotoxic
changes in buccal epithelial cells of these children. We also observed
marked increase in argyrophilic nuclear organizer region (AgNOR)
in buccal epithelial cells of glue-addicted children, suggesting up-
regulation of ribosome biogenesis in these cells [12]. Taken together,
these studies indicate genetic changes in oral mucosa of street boys
in association with tobacco and glue sning or hung habit. So it
is necessary to campaign biosafety and health education programme
explaining the adverse health eects of inhalant abuse by the young
futures throughout the nation. Genetic markers could provide a useful
means of detecting early mutagenic events for assessing cancer risk
associated with inhalant abuse which is quite prevalent in developed
countries also. In the United States, for example, nearly 20% of young
persons have experimented with inhalants at least once by the time they
are in eighth grade and the mean age of rst-time inhalant abuse is
13 years [13]. More importantly, children who abuse inhalants early in
life are more likely later to use other illicit drugs. us inhalant abuse
intervention programs seem important from the community health
perspective also.
References
1. Benegal V, Bhushan K, Seshadri S, Karott M (1998) Drug Abuse Among Street
Children in Bangalore. Monograph Funded by CRY.
2. Basu D, Jhirwal OP, Singh J, Kumar S, Mattoo SK (2004) Inhalant abuse by
adolescents: a new challenge for Indian physicians. Indian J Med Sci 58: 245-
249.
3. Seth R, Kotwal A, Ganguly KK (2005) Street and working children in Delhi,
India, misusing toluene: an ethnographic exploration. Subst Use Misuse 40:
1659-1679.
4. Marjot R, McLeod AA (1989) Chronic non-neurological toxicity from volatile
substance abuse. Hum Toxicol 8: 301-306.
5. Inhalants (2004) National Institute on Drug Abuse, National Institutes of Health,
U.S. Department of Health & Human Services.
6. Gupta SK, Bali S, Jiloha RC (2009) Inhalant abuse: an overlooked problem.
Indian J Psychiatry 51: 160-161.
7. Weir E (2001) Inhalant use and addiction in Canada. CMAJ 164: 397.
8. Ramon MF, Ballesteros S, Martinez-Arrieta R, Torrecilla JM, Cabrera J (2003)
Volatile substance and other drug abuse inhalation in Spain. J Toxicol Clin
Toxicol 41: 931-936.
9. Thiesen FV, Barros HM (2004) Measuring inhalant abuse among homeless
youth in southern Brazil. J Psychoact Drugs 36: 201-205.
*Corresponding author: Nandan Kumar Mondal, Articial Organ Laboratory,
Department of Surgery, University of Maryland School of Medicine, 10 South Pine
Street, Baltimore, Maryland 21201, USA, Tel: 410-706-4549; Fax: 410-706-0311;
E-mail: nkmondal@smail.umaryland.edu
Received
May 12, 2013; Accepted May 16, 2013; Published May 18, 2013
Citation: Mondal NK (2013) Commercial Glue Snifng and Child Health: Indian
Street Children are at a Risk. J Biosafety Health Educ 1: e108. doi:10.4172/
jbhe.1000e108
Copyright: © 2013 Mondal NK. This is an open-access article distributed under
the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and
source are credited.
Commercial Glue Sniffing and Child Health: Indian Street Children are at a
Risk
Nandan Kumar Mondal*
Articial Organ Laboratory, Department of Surgery, University of Maryland School of Medicine, USA
Page 2 of 2
J Biosafety Health Educ
ISSN: JBHE an open access journal
10. Wu LT, Pilowsky DJ, Schlenger WE (2004) Inhalant abuse and dependence
among adolescents in the United States. J Am Acad Child Adolesc Psychiatry
43: 1206-1214.
11. Mondal NK, Ghosh S, Ray MR (2011) Micronucleus formation and DNA
damage in buccal epithelial cells of Indian street boys addicted to gasp ‘Golden
glue’. Mutat Res 721: 178-183.
12. Mondal NK, Ghosh S, Ray MR (2011) Quantitative analysis of AgNOR proteins
in buccal epithelial cells of Indian street boys addicted to gasp ‘golden glue’.
Exp Toxicol Pathol 63: 677-681.
13. McGarvey EL, Clavet GJ, Mason W, Waite D (1999) Adolescent inhalant abuse:
environments of use. Am J Drug Alcohol Abuse 25: 731-741.
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Citation: Mondal NK (2013) Commercial Glue Snifng and Child Health: Indian Street Children are at a Risk. J Biosafety Health Educ 1: e108.
doi:10.4172/jbhe.1000e108
Volume 1 • Issue 3 • 1000e108
Citation: Mondal NK (2013) Commercial Glue Snifng and Child Health: Indian
Street Children are at a Risk. J Biosafety Health Educ 1: e108. doi:10.4172/
jbhe.1000e108
... It is the firm view that if people are more informed about the lifestyle of these children, they may be more sensitive to their needs. Mondal (2013) holds the firm view that "Children are the source of hope and inspiration for the society." He further insists: "That is why they have the right to be brought up in a positive environment"". ...
... He further insists: "That is why they have the right to be brought up in a positive environment"". This perspective by Mondal (2013) is crucial, but it is completely contrasting when one tries to arrive at a conceivable definition of street children. There exist many definitions on the grounds that different countries construe them in several ways. ...
... Sanjay et al. (2019) support this position and further claim that the phenomenon of street children is very common in many cities of Nepal. Mondal (2013) also believes that this difficulty exists because these children are marginalized and form a "hidden" population. He states that this issue is further exacerbated since the population often fluctuates. ...
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... Quantitative data collected from the field are sorted. Mondal (2013) firmly believes that children are a source of hope and inspiration for society. "Therefore, they have a right to grow up in a positive environment." ...
... This perspective of Mondal (2013) is important but completely contradictory when trying to arrive at a possible street-her definition of children. [10] There are many definitions as different countries interpret them in different ways. So, it's very complicated to formulate the exact one for them. ...
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Generally, situations of poverty, illiteracy, disease and social injustice are the causes of becoming street children. Focusing on this study, we prioritized children sleeping on the street, stations and platforms, bus stops, parks, religious sites, construction sites, around cemeteries, and other large open public areas. This research focuses primarily on health and Education of street children from 6 to 16 years old in various Thana of Dhaka cities. A schedule is created and maintained to collect data. Statistical evaluation included Frequency and Percentages for all Sections interview planning. Thematic content Analysis was used to analyze data from open-ended questions and observations. The case studies the lives of the children, usually in difficult situations. The results showed that the quality of life of the participants in this study was depressed due to lack of access, substandard educational and medical facilities, or lack of emotion. Findings show that homeless children had to live very precarious lives. A humiliating life on the street without all the basic comforts of life and under constant threat of expulsion or harassment by bad guys or crooks, they work hard to achieve their goals. However, due to their involvement in the low-wage informal sector, their demands are rarely met.
... (Nandan Kumar Mondal, 2013) There is study suggested that children who starts abusing inhalants or other solvents in early stages of life they are more likely later to use other illicit drugs in their future. Thus, inhalant abuse intervention programmes seem important from the community health perspective also (Mondal, 2013). ...
... (Nandan Kumar Mondal, 2013) There is study suggested that children who starts abusing inhalants or other solvents in early stages of life they are more likely later to use other illicit drugs in their future. Thus, inhalant abuse intervention programmes seem important from the community health perspective also (Mondal, 2013). ...
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Aim: The aim was to determine the prevalence of glue-sniffing among street children. Design: A descriptive cross-sectional study design was adopted. Background: Children are the source of hope and could be the major ailments for the development of society, nation and the world but there are large numbers of children on the street sniff glue and struggling with multiple disease and uncertain future. Methods: A study was conducted in 52 street children to determine the prevalence of glue-sniffers and its impact on street children in Butwal, municipality of Nepal. This study was conducted in 52 street children, 5- point Likert scale and interview schedule was performed with the help of structured and semi-structured questionnaire to collect data. Finally, the collected data are analysed by using descriptive statistical methods such as frequency, percentage and mean. Results: The study findings revealed that a large number of children, that is 40.38% was between the age group of 9-12 years and 92.31% were male. The current prevalence of glue-sniffing among street children is 88.46%. Similarly, 58.7% of respondents had started glue-sniffing 1 year ago. Out of 46 respondents who sniffed glue, 89.13% were unaware of its effect. Nearly, half of the respondents 45.65% had encountered health issues such as headache, chest pain and stomach ache. Conclusions: They have deprived children and denied not only of their rights as children but also of their normal childhood. Without guidance, education and security, they are heading towards an uncertain future. They can have enough potentiality and talent if they are brought into a better environment and might have real hope for the bright future.
... It has been noted that sniffing of glue and other volatile substance abuse increased the risk of addiction to other substances. 21,22 Though this is one of the few studies which tries to provide insight into the characteristics of street children who are engaged in glue sniffing and its health consequences, this study has its limitations. ...
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Introduction: Glue sniffing usually refers to volatile substance abuse (VSA) for psychoactive effects. Street children are the children who live, work, and earn their livelihood through the streets of urban settlements. Street children are mostly attracted to substance abuse and more particularly towards volatile substances as they are cheap, easy to access and have psychoactive effects as alcohol intoxication. This study aimed to assess the general characteristics of street children of Pokhara Metropolitan, Nepal who are addicted to glue sniffing. Methods: A cross-sectional study was conducted among street children who were addicted to glue sniffing through the snowball sampling method in Pokhara Metropolitan, Nepal. Results: All 88 children who were addicted to glue sniffing were males. Of the total children, 59 (67%) children started glue-sniffing at the age of five to ten years of age while nine (10.2%) children started sniffing even before they were five years old. Addiction to glue (n = 33, 37.5%), pleasure (n = 18, 20.5%)), coping with hunger (n = 14, 15.9%), and being a part of street children group (n = 13, 14.8%) were the major reasons to sniff glue for these children. Conclusions: It has been observed that the majority of street children are at increased risk of getting involved in glue sniffing. It has resulted in different ill outcomes such as self-destruction and problematic behavior, fights and police arrest. There is a need to focus on the issue of glue sniffing among the street children to save and ensure the quality of life of these vulnerable children.
... 26 Another meta-analysis study by Mondal states that streets boys living in railway platforms and footpaths of West Bengal, Bhutan, Bangladesh were addicted to glue tubes, cans and rubber cement (type of adhesive) are favorite particulars of children. They also demonstrated that sniffing or huffing of glue/adhesive enhance the genotoxic affect in epithelial cells of mucosa of these children which suggest that there might be genetic alternations that may cause mutagenic events and cause cancers 25 . Another case illustrates a 22-year-old man covered his face with plastic bag having large amount of glue in it. ...
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This review article explores the studies of inhalants and inhalant misuse in India. Since much research is focused on illegal drugs not much work had concentrated on the commonly available inhalants. The abuse of inhalants is common phenomenon in the world. In this review, we will explain why these inhalants addiction is an inalienable thing which depressed youths can't avoid. Then we will look into various inhalants commonly used and also into various case studies available in the literature hence knowing the abuse of inhalants among youths and techniques employed by them to get a kick.
... The age of initiation was between 10 and 13 for street children who commonly use and abuse substance like alcohol, cigarettes, inhalants, cocaine, marijuana, heroin, shoemakers glue, correction fluid, paint thinner; and coca paste (Nada KH et al.; Hillis SD et al.; Elkoussi A et al.) as quoted in Cumber SM et al. Young persons have experimented with inhalants at least once by the time they are in eight grade and mean age of first-time inhalant abuse is 13 years, McGarvey EL et al. as quoted in Mondal NK[23]. Sampasa-Kanyinga H et al.[24], some students reported having tried cannabis for the first time as early elementary school. ...
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DRUG ABUSE AMONG STREET CHILDREN (Case Study: Commercial Vans Casual Apprentices at Car Parks) Yahya Muhammed Bah* University of The Gambia, School of Arts and Sciences, Brikama Campus, The Gambia, West Africa *Corresponding author: yahyamuhammed@yahoo.co.uk Abstract In The Gambia like all nations, drug abuse is seen as a social and health problem that has many serious implications for the physical, social, psychological and intellectual development of the victims more especially, the children. Therefore, it continues to be a concern to families, community leaders, educators, social workers, health care professionals, academics, government and its development partners. Though there are some studies on drug abuse, there is none on children and drug abuse focusing on the street children the most vulnerable category. Street children are hypothesized to be more at risk of any epidemic including drug abuse. This study sought to determine the risk and prevalence of drug abuse among street children focusing on those in the car parks. The research was focused on six critical areas: level of knowledge of drug abuse, perception towards it, level of knowledge of the causes of it in the community and among street children, level of knowledge of negative impacts of it, level of knowledge of the preventive methods; and level of knowledge of the support services and treatments needed by victims. A structured questionnaire was used to collect the data from thirty five participants (i.e. one driver and six casual apprentices from each of the five car parks) were interviewed. The data was presented and analyzed using tables and percentage. The findings revealed among other things, that there is high level of awareness of drug abuse but the feelings towards it are mixed. Like other children, street children are abusing drugs mainly due to peer influence with the ultimate objective of getting high to relief stress, group recognition, desire to be trusted by peers, etc. Similarly, participants are highly aware of the negative impacts encompassing fighting, stealing, mental illness, etc. To finance the behavior, victims are engaged in all types of dangerous antisocial behavior including romantic ones exposing them to a range of diseases including STIs and HIV/AIDS. Marijuana is the most commonly abused drug. Though in the minority, some have started experimenting cocaine/coke, hashish; and heroin. While participants have good knowledge of the critical methods to fight drug abuse, the support services needed by victims, victims are mostly reluctant to seek the services not only because they are hard to find but fear societal stigmatization, exclusion and discrimination and professionals’ maltreatment. Keywords: drugs, abuse, street children, casual van apprentice; and commercial van driver.
Chapter
Street children, who are they? Why are they homeless? How do they actually live on the streets? What quality of life do they enjoy? What are the characteristics of these children? These questions appear to be simple, but the answers are so very complex. Very often the public lacks proper information about these children, and they instinctively judge and cast aspersions on them. This chapter presents a clear understanding of some of the characteristics of street children. With the use of current literature, it tries to provide a definition and quantify the number of street children. It explains the difference between children “on” and “of” the streets and highlights some of the notions of street culture. It is the firm view that if the public is more cognizant of the reasons these children live on the streets, they may tend to be sympathetic and understanding to their needs. This chapter does not evoke sensationalism but tries as far as possible to create an awareness of the lifestyle of street children.
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Background: Although glue sniffing has been linked with significant morbidity and mortality, it is still under-researched and poorly recognized issue globally. Objective: A scoping review was performed to identify the factors and outcomes related to glue sniffing in India, Pakistan, Nepal and Bangladesh. Methods: Ten databases; Medline via Ovid, Google scholar, EBSCOhost (CINAHL Plus), ProQuest Central, PsycInfo, IndMED, Ovid Embase, Scopus, PubMed, and Science Direct were searched from their inception to January 2019 for both qualitative and quantitative studies examining any aspect of glue-sniffing. Studies published only in English language were included. Prevalence of glue-sniffing in SAARC region was the primary outcome measure. Findings: Of 8951studies screened, 344 were assessed for eligibility and 31 studies were included. The majority of the studies were conducted in India (15) and Pakistan (11). Meta-analysis of proportion, using random effects model, for both primary and secondary outcomes found that the highest incidence of glue sniffing was 57% (0.57, CI 95% 0.49-0.66) in India. The overall incidence of tobacco and naswar (snuff) as was 83% (0.83, 95% CI 0.80-0.86). Conclusions: The prevalence of glue sniffing, especially among street children, is alarmingly high and presents a challenge for health and social services for countries in SAARC region. More research work is required to examine long term impact of glue sniffing on physical and mental health.
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In The Gambia like all nations, drug abuse is seen as a social and health problem that has many serious implications for the physical, social, psychological and intellectual development of the victims more especially, the children. Therefore, it continues to be a concern to families, community leaders, educators, social workers, health care professionals, academics, government and its development partners. Though there some studies on drug abuse, there is none on children and drug abuse focusing on the street children the most vulnerable category. Street children are hypothesized to be more at risk of any epidemic including drug abuse. This study sought to determine the risk and prevalence of drug abuse among street children focusing on those in the car parks. The research was focused on six critical areas: level of knowledge of drug abuse, perception towards it, level of knowledge of the causes of it in the community and among street children, level of knowledge of negative impacts of it, level of knowledge of the preventive methods; and level of knowledge of the support services and treatments needed by victims. A structured questionnaire was used to collect the data from thirty five participants (i.e. one driver and six casual apprentices from each of the five car parks) were interviewed. The data was presented and analysed using tables and percentage. The findings revealed among other things, that there is high level of awareness of drug abuse but the feelings towards it is mixed. Like other children, street children are abusing drugs mainly due to peer influence with the ultimate objective of getting high to relief stress, group recognition, trusted by peers, etc. Similarly, participants are highly aware of the negative impacts encompassing fighting, stealing, mental illness, etc. To finance the behaviour, victims are engaged in all types of dangerous antisocial behaviour including romantic ones exposing them to a range of diseases including STIs and HIV/AIDS. Marijuana is the most commonly abused drug. Though in the minority, some have started experimenting cocaine/coke, hashish; and heroin. While participants have good knowledge of the critical methods to fight drug abuse, the support services needed by victims, victims are mostly reluctant to seek the services not only because they are hard to find but fear societal stigmatization, exclusion and discrimination and professionals’ maltreatments.
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In The Gambia like all nations, drug abuse is seen as a social and health problem that has many serious implications for the physical, social, psychological and intellectual development of the victims more especially, the children. Therefore, it continues to be a concern to families, community leaders, educators, social workers, health care professionals, academics, government and its development partners. Though there are some studies on drug abuse, there is none on children and drug abuse focusing on the street children the most vulnerable category. Street children are hypothesized to be more at risk of any epidemic including drug abuse. This study sought to determine the risk and prevalence of drug abuse among street children focusing on those in the car parks. The research was focused on six critical areas: level of knowledge of drug abuse, perception towards it, level of knowledge of the causes of it in the community and among street children, level of knowledge of negative impacts of it, level of knowledge of the preventive methods; and level of knowledge of the support services and treatments needed by victims. A structured questionnaire was used to collect the data from thirty five participants (i.e. one driver and six casual apprentices from each of the five car parks) were interviewed. The data was presented and analyzed using tables and percentage. The findings revealed among other things, that there is high level of awareness of drug abuse but the feelings towards it are mixed. Like other children, street children are abusing drugs mainly due to peer influence with the ultimate objective of getting high to relief stress, group recognition, desire to be trusted by peers, etc. Similarly, participants are highly aware of the negative impacts encompassing fighting, stealing, mental illness, etc. To finance the behavior, victims are engaged in all types of dangerous antisocial behavior including romantic ones exposing them to a range of diseases including STIs and HIV/AIDS. Marijuana is the most commonly abused drug. Though in the minority, some have started experimenting cocaine/coke, hashish; and heroin. While participants have good knowledge of the critical methods to fight drug abuse, the support services needed by victims, victims are mostly reluctant to seek the services not only because they are hard to find but fear societal stigmatization, exclusion and discrimination and professionals’ maltreatments.
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To examine the patterns of inhalant use and correlates of the progression from inhalant use to abuse and dependence among adolescents aged 12 to 17. Study data were drawn from the 2000 and 2001 National Household Surveys on Drug Abuse. Multinominal logistic regression was used to identify the characteristics associated with progression to inhalant abuse and dependence. Inhalant use was common among the studied adolescents. Among adolescents aged 12 to 17, 0.4% met DSM-IV inhalant abuse or dependence criteria in the past year. Inhalant abuse and dependence affected adolescents regardless of gender, age, race/ethnicity, and family income. The progression from inhalant use to abuse or dependence was related to early first use, use of multiple inhalants, and weekly inhalant use. Adolescents with inhalant use disorders reported coexisting multiple drug abuse and dependence, mental health treatment, and delinquent behaviors. Adolescents with an inhalant use disorder may represent a subgroup of highly troubled youths with multiple vulnerabilities. Because early use is associated with progression to abuse and dependence, prevention programs should target elementary school-age children.
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Genotoxicity of glue sniffing/huffing and tobacco use has been examined in 302 street boys (median age 13 years) and 50 age-matched control school boys who were neither tobacco nor glue users. All the street boys were tobacco users. In addition, 155 were addicted to gasp an industrial adhesive popularly known as 'Golden glue'. Micronucleus (MN) frequency was determined as a measure of chromosomal breakage in exfoliated buccal epithelial cells (BECs) and DNA double strand breaks were quantitatively assessed by counting γ-H2AX foci using immunofluorescence microscopy. Micronucleated cell frequencies (MCFs) in BEC of glue non-addicted (only tobacco) and addicted (tobacco plus glue) street boys were 1.87 ± 1.06‰ and 4.04 ± 2.55‰ respectively, which were significantly higher than that of control (0.32 ± 0.11‰, p<0.0001). Similarly, the numbers γ-H2AX foci in nuclei of BEC were 2.3- and 5.2-times more than control in glue non-addicted and addicted street boys respectively (p<0.0001). Spearman's rank correlation revealed a strong positive association between years of glue addiction with MCFs and γ-H2AX foci numbers, and the association between glue addiction and chromosomal and DNA damage remained positive and significant after controlling income, spending on addiction and loss of appetite as potential confounders in multivariate logistic regression analysis. Thus, addiction to tobacco among the street children in India is associated with chromosomal and DNA damage in BECs and the severity of these changes is significantly increased by the habit of sniffing/huffing of industrial glue.
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The effect of glue snuffle on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa has been investigated. AgNOR was evaluated by cytochemical staining in 148 Indian street boys (median age 12 year) who had different bad addictions like tobacco smoking, chewing and most importantly inhaling glue and 20 age- and body mass index-matched school boys who had no such type of bad habit. Compared with school boys, glue addicted street boys showed remarkably increased number of AgNOR dots per nucleus (9.38±1.84 vs. 3.12±0.87, p<0.001), AgNOR size (1.34±0.52 vs. 0.43±0.02 μm(2), p<0.001) and percentage of AgNOR occupied nuclear area (9.38±2.12 vs. 0.99±0.03%, p<0.001). Increase in number and size of the dots is also higher in tobacco smokers and chewers when compared with school boys but a remarkable difference was recorded in glue addicted boys. The changes in AgNOR expression were positively associated with years of addiction after controlling potential confounders. Thus, glue snuffle appeared to be a risk factor for abnormal cell growth via up-regulation of ribosome biogenesis.
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1 Most of the evidence for chronic non-neurological toxicity from volatile substance abuse is derived from case reports. 2 Factors important in assessing these reports are the marked variations in exposure conditions and in the composition of the products abused. 3 In a young and otherwise healthy population, any chronic organ toxicity arising from VSA has to be gross in order to become clinically apparent. This may partially explain the relatively low incidence of reporting. 4 Toluene and the chlorinated hydrocarbons 1,1,1-trichloroethane and trichloroethylene can cause permanent damage to the kidney, liver, heart and lung, in certain volatile substance abusers.
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